Parkin in Parkinson’s Disease and Cancer: a Double-Edged Sword

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation

(2017) Amit Gupta et al.   MOLECULAR CELL

Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis

(2017) Yongxing Gong et al.   NEOPLASIA

Parkin Regulates the Activity of Pyruvate Kinase M2

(2016) Kun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple-level validation identifies PARK2 in the development of lung cancer and chronic obstructive pulmonary disease

(2016) SeungBaek Lee et al.   Oncotarget

Parkin induces G2/M cell cycle arrest in TNF-α-treated HeLa cells

(2015) Min Ho Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1

(2015) Seung Baek Lee et al.   MOLECULAR CELL

PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper

(2015) Asad A. Aboud et al.   NEUROBIOLOGY OF DISEASE

Differential risks of cancer types in people with Parkinson’s disease: A national record-linkage study

(2014) E.L. Ong et al.   EUROPEAN JOURNAL OF CANCER

PARK2 orchestrates cyclins to avoid cancer

(2014) Jiri Bartek et al.   NATURE GENETICS

Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

(2014) Yongxing Gong et al.   NATURE GENETICS

Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation

(2013) Xiaodong Sun et al.   CELL CYCLE

The hallmarks of Parkinson's disease

(2013) Paul M. A. Antony et al.   FEBS Journal

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

(2013) Michael Lazarou et al.   JOURNAL OF CELL BIOLOGY

An emerging role of PARK2 in cancer

(2013) Liang Xu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Parkin-Dependent Degradation of the F-Box Protein Fbw7  Promotes Neuronal Survival in Response to Oxidative Stress by Stabilizing Mcl-1

(2013) S. Ekholm-Reed et al.   MOLECULAR AND CELLULAR BIOLOGY

Lysosomal impairment in Parkinson's disease

(2013) Benjamin Dehay et al.   MOVEMENT DISORDERS

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

(2013) Paolo S. Manzanillo et al.   NATURE

Cigarette smoking and inflammation revisited

(2013) Oren Rom et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

Parkin induces apoptotic cell death in TNF-α-treated cervical cancer cells

(2012) Kyung-Hong Lee et al.   BMB Reports

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

(2012) Jueng Soo You et al.   CANCER CELL

Parkin Pathway Activation Mitigates Glioma Cell Proliferation and Predicts Patient Survival

(2012) C. W. S. Yeo et al.   CANCER RESEARCH

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

(2012) Michael H. Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

(2012) B. N. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The familial Parkinson Disease gene PARK2 is a multisite tumor suppressor on chromosome 6q25.2-27 that regulates cyclin E

(2011) Selvaraju Veeriah et al.   CELL CYCLE

Autoregulation of Parkin activity through its ubiquitin-like domain

(2011) Viduth K Chaugule et al.   EMBO JOURNAL

Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria

(2011) S. Schmidt et al.   HUMAN MOLECULAR GENETICS

Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells

(2011) Kye-Young Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

(2011) Magdalini Polymenidou et al.   NATURE NEUROSCIENCE

Restriction of trophic factors and nutrients induces PARKIN expression

(2011) M. Klinkenberg et al.   NEUROGENETICS

Meta-analysis of the relationship between Parkinson disease and melanoma

(2011) R. Liu et al.   NEUROLOGY

Parkin Mediates Apparent E2-Independent Monoubiquitination In Vitro and Contains an Intrinsic Activity That Catalyzes Polyubiquitination

(2011) Katherine C. M. Chew et al.   PLoS One

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of cell migration by dynamic microtubules

(2011) Irina Kaverina et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Common fragile sites: mechanisms of instability revisited

(2011) Michelle Debatisse et al.   TRENDS IN GENETICS

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

(2010) L Bouman et al.   CELL DEATH AND DIFFERENTIATION

Replication dynamics at common fragile site FRA6E

(2010) Elisa Palumbo et al.   CHROMOSOMA

Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

(2010) Dong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Enhances the Expression of Cyclin-dependent Kinase 6 and Negatively Regulates the Proliferation of Breast Cancer Cells

(2010) Shiam-Peng Tay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allelic loss of 6q25-27, the PARKIN tumor suppressor gene locus, in cervical carcinoma

(2010) S. J. Mehdi et al.   MEDICAL ONCOLOGY

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

(2010) G. Poulogiannis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

(2010) H. S. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of DNA repair by parkin

(2009) Shyan-Yuan Kao   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling

(2009) Anna Sandebring et al.   FEBS Journal

Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair

(2009) Oliver Rothfuss et al.   HUMAN MOLECULAR GENETICS

Attenuation of proteolysis-mediated cyclin E regulation by alternatively splicedParkinin human colorectal cancers

(2009) Kyoko Ikeuchi et al.   INTERNATIONAL JOURNAL OF CANCER

Protein degradation in Parkinson disease revisited: it’s complex

(2009) Han Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired dopamine release and synaptic plasticity in the striatum ofParkin−/− mice

(2009) Tohru Kitada et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Parkinson’s Disease

(2009) Jae-Kyung Lee et al.   Journal of Neuroimmune Pharmacology

Mice Expressing Mutant Parkin Exhibit Hallmark Features of Parkinson's Disease

(2009) M. P. Hart et al.   JOURNAL OF NEUROSCIENCE

Parkin regulates paclitaxel sensitivity in breast cancer via a microtubule-dependent mechanism

(2009) Hongxia Wang et al.   JOURNAL OF PATHOLOGY

Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

(2009) Selvaraju Veeriah et al.   NATURE GENETICS

Molecular basis of Parkinsonʼs disease

(2009) Yan Xiang Yang et al.   NEUROREPORT

Cancer risk in association with Parkinson disease: A population-based study

(2009) Claudia Becker et al.   PARKINSONISM & RELATED DISORDERS

Combined kinase inhibition modulates parkin inactivation

(2008) E. Rubio de la Torre et al.   HUMAN MOLECULAR GENETICS

Parkin Protects Dopaminergic Neurons against Microtubule-depolymerizing Toxins by Attenuating Microtubule-associated Protein Kinase Activation

(2008) Yong Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glial Dysfunction in Parkin Null Mice: Effects of Aging

(2008) R. M. Solano et al.   JOURNAL OF NEUROSCIENCE