Article
Biochemistry & Molecular Biology
Yuxiang Li, Fangchao Tong, Lu Liu, Zhongqian Su, Jing Ding, Qiang Wang, Xin Wang
Summary: Mossy fiber sprouting is a characteristic of epilepsy and plays a key role in neural circuit formation. CRMP2, whose phosphorylation state regulates neurite/axon outgrowth, has been reported to change in epilepsy patients and animal models. This study provides direct evidence supporting the role of CRMP2 in mossy fiber sprouting in an animal model of epilepsy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Ting-Ting Du, Ying-Chuan Chen, Guan-Yu Zhu, De-Feng Liu, Yu-Ye Liu, Tian-Shuo Yuan, Xin Zhang, Jian-Guo Zhang
Summary: ATN-DBS significantly reduces seizure frequency, decreases the number of ectopic granule cells, and reduces MFS scores in the hippocampus through down-regulation of the cAMP/PKA signaling pathway and Akt phosphorylation.
CHINESE MEDICAL JOURNAL
(2021)
Article
Neurosciences
Kai-Ge Ma, Hai-Bo Hu, Jin-Song Zhou, Chao Ji, Qi-Sheng Yan, Si-Ming Peng, Lan-Dong Ren, Bing-Nan Yang, Xin-Li Xiao, Yan-Bing Ma, Feng Wu, Kai-Wei Si, Xiao-Lin Wu, Jian-Xin Liu
Summary: It has been found that Gpc4 plays a crucial role in the development of mossy fiber sprouting in the hippocampus, with the mTOR pathway being essential for Gpc4-regulated MFS. Additionally, suppressing Gpc4 expression after status epilepticus has shown to attenuate spontaneous recurrent seizures, indicating that Gpc4 may be a promising target for antiepileptic studies.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Young-Jin Kang, Sang -Hun Lee, Jeffery A. Boychuk, Corwin R. Butler, J. Anna Juras, Ryan A. Cloyd, Bret N. Smith
Summary: Post-traumatic epilepsy and behavioral comorbidities often occur after traumatic brain injury. The neurogenesis of dentate granule cells after injury may contribute to the synaptic reorganization in epilepsy, but the specific role of neurogenesis at different times relative to the injury is unknown. This study found that the birth date of dentate granule cells is related to increased feedback inhibition in the dentate gyrus, which may contribute to altered excitability after brain injury.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Yilun Chen, Songlu Li, Wendong Ge, Jin Jing, Hsin Yi Chen, Daniel Doherty, Alison Herman, Safa Kaleem, Kan Ding, Gamaleldin Osman, Christa B. Swisher, Christine Smith, Carolina B. Maciel, Ayham Alkhachroum, Jong Woo Lee, Monica B. Dhakar, Emily J. Gilmore, Adithya Sivaraju, Lawrence J. Hirsch, Sacit B. Omay, Hal Blumenfeld, Kevin N. Sheth, Aaron F. Struck, Brian L. Edlow, M. Brandon Westover, Jennifer A. Kim
Summary: This study evaluated the contribution of quantitative electroencephalograms in predicting post-traumatic epilepsy (PTE) and found that these features enhance the predictive value of PTE1, especially when combined with TBI mechanism and CT abnormalities. Future research should validate these findings.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Kyoung Hoon Jeong, Jing Zhu, Soojin Park, Won-Joo Kim
Summary: The role of TRPV6 in epilepsy is unclear. This study found that TRPV6 expression is upregulated in the hippocampus of a pilocarpine-induced status epilepticus model and is related to abnormal MF sprouting (MFS) and the incidence of seizures. In vitro experiments showed that TRPV6 expression can regulate axonal formation in cultured hippocampal neurons. Furthermore, TRPV6 is involved in the regulation of Akt-glycogen synthase kinase-3-beta activity, which is related to axonal outgrowth. Therefore, TRPV6 may regulate the formation of aberrant synaptic circuits during epileptogenesis.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Eppu Manninen, Karthik Chary, Niina Lapinlampi, Pedro Andrade, Tomi Paananen, Alejandra Sierra, Jussi Tohka, Olli Grohn, Asla Pitkanen
Summary: This study aimed to identify MRI biomarkers for post-traumatic epilepsy in Sprague-Dawley rats with traumatic brain injury. The researchers found that a combination of T-2 relaxation time and diffusion tensor data could distinguish rats with and without epilepsy, and even a single time-point measurement could significantly enrich the epilepsy rate within the study population.
Article
Neurosciences
Dandan Wang, Mei-fang Jin, Lili Li, Yueying Liu, Yuxiao Sun, Hong Ni
Summary: PRG5 gene knockout significantly reduces seizure latency and exacerbates the lowered seizure threshold induced by developmental seizures. Additionally, knocking out the PRG5 gene reduces the amount of mossy fiber sprouting to a certain extent. Furthermore, silencing the PRG5 gene significantly increases zinc ion content in hippocampal neurons, impairs neuronal activity and mitochondrial function, and worsens glutamate-induced oxidative stress damage.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Behavioral Sciences
William H. Curley, Yelena G. Bodien, David W. Zhou, Mary M. Conte, Andrea S. Foulkes, Joseph T. Giacino, Jonathan D. Victor, Nicholas D. Schiff, Brian L. Edlow
Summary: This study demonstrates the use of the ABCD framework to assess EEG dynamics and track changes in thalamocortical network function in patients with acute severe traumatic brain injury. The findings suggest that ABCD classifications can provide valuable information for monitoring recovery and predicting outcomes.
Article
Neurosciences
Fang-Cheng Yeh, Andrei Irimia, Dhiego Chaves de Almeida Bastos, Alexandra J. Golby
Summary: This review discusses the challenges of anatomical accuracy in fiber tracking, explores the impact of different white matter pathways on tracking methods, and summarizes the pros and cons of commonly-used techniques. Additionally, it introduces the progress in clinical applications of tractography in patients with brain tumors and traumatic brain injury, highlighting current limitations and future directions for development.
Article
Neurosciences
Yuxiang Li, Fangchao Tong, Yiying Zhang, Yiying Cai, Jing Ding, Qiang Wang, Xin Wang
Summary: Programmed neural circuit formation is crucial for normal brain functions. This study revealed a novel role of axon guidance molecule family Sema3F/Npn-2 signaling in mossy fiber sprouting (MFS) and epileptogenesis in adult epilepsy animals. Knockdown of Npn-2 in the dentate gyrus led to increased seizure activity and MFS. Npn-2 signaling was found to modulate MFS through regulating axon outgrowth and collateral formation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Joel Frohlich, Julia S. Crone, Micah A. Johnson, Evan S. Lutkenhoff, Norman M. Spivak, John Dell'Italia, Joerg F. Hipp, Vikesh Shrestha, Jesus E. Ruiz Tejeda, Courtney Real, Paul M. Vespa, Martin M. Monti
Summary: This study confirms the validity of the ABCD model in predicting behavioral recovery in patients with moderate-to-severe traumatic brain injury. It outperforms data-driven clustering methods and may be equally effective as a more simplified categorization. Additionally, a correlation between EEG findings and functional magnetic resonance imaging provides further evidence for investigation in larger studies.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemistry & Molecular Biology
Li Zhang, Xiaowen Xu, Liya Ma, Xinxin Wang, Meifang Jin, Lili Li, Hong Ni
Summary: This study explores the effects of zinc water supplementation on autism-like behavior, seizure threshold, and neurogenesis in ASD model mice. The results show that zinc water supplementation for 6 weeks can prevent autism-like behavior, reduce susceptibility to seizures, and increase the proliferation of hippocampal progenitor cells in BTBR mice. However, it has less effect on mossy fiber sprouting and neural progenitor cell differentiation. The findings suggest that zinc water can reduce autism-like behavior in a partially inherited autism model mice by promoting hippocampal neural precursor cell proliferation and reversing hyperexcitability.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Medicine, General & Internal
Chao Zhang, Wen-Dong You, Xu-Xu Xu, Qian Zhou, Xiao-Feng Yang
Summary: The novel nomogram model combining AEEG parameters showed potential in predicting outcomes in severe TBI coma patients receiving RMNS treatment, effectively classifying patients into prognostic groups and demonstrating good predictive ability.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Emma -Jane Mallas, Nikos Gorgoraptis, Sophie Dautricourt, Yoni Pertzov, Gregory Scott, David J. Sharp
Summary: Associative binding is disrupted during post-traumatic amnesia (PTA) following traumatic brain injury (TBI). This disruption is caused by pathological slowing of brain activity, leading to misbinding in working memory. The study found that PTA patients showed abnormalities in working memory function and made more misbinding errors than controls. Slow-wave activity and increased low-frequency power were associated with binding impairment in working memory. Connectivity changes in TBI did not contribute to binding impairment. Overall, these findings highlight the importance of associative binding in memory function and its disruption in PTA following TBI.
JOURNAL OF NEUROSCIENCE
(2022)
