Neuroprotective Potential of Silymarin against CNS Disorders: Insight into the Pathways and Molecular Mechanisms of Action

L-DOPA induced-endogenous 6-hydroxydopamine is the cause of aggravated dopaminergic neurodegeneration in Parkinson’s disease patients

(2012) Anupom Borah et al.   MEDICAL HYPOTHESES

Protection by silibinin against experimental ischemic stroke: Up-regulated pAkt, pmTOR, HIF-1α and Bcl-2, down-regulated Bax, NF-κB expression

(2012) Chaohui Wang et al.   NEUROSCIENCE LETTERS

Silymarin improves the behavioural, biochemical and histoarchitecture alterations in focal ischemic rats: A comparative evaluation with piracetam and protocatachuic acid

(2012) Milind M. Muley et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

(2011) Mathias Jucker et al.   ANNALS OF NEUROLOGY

Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: A behavioral, biochemical and immunohistological study in Wistar rats

(2011) Syed Shadab Raza et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Variants in estrogen-related genes and risk of Parkinson's disease

(2011) Sun Ju Chung et al.   MOVEMENT DISORDERS

Amyloid: Little proteins, big clues

(2011) Jim Schnabel   NATURE

Improvement of Cerebellum Redox States and Cholinergic Functions Contribute to the Beneficial Effects of Silymarin Against Manganese-Induced Neurotoxicity

(2011) Yassine Chtourou et al.   NEUROCHEMICAL RESEARCH

Neurodegeneration and Inflammation in Parkinson's disease

(2011) Sudarshan Phani et al.   PARKINSONISM & RELATED DISORDERS

Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease

(2011) Bradley Robottom   Patient Preference and Adherence

MAO-inhibitors in Parkinson's Disease

(2011) Peter Riederer et al.   Experimental Neurobiology

Silymarin, a natural antioxidant, protects cerebral cortex against manganese-induced neurotoxicity in adult rats

(2010) Yassine Chtourou et al.   BIOMETALS

Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model

(2010) Nakaba MURATA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Salicylic acid protects against chronic l-DOPA-induced 6-OHDA generation in experimental model of parkinsonism

(2010) Anupom Borah et al.   BRAIN RESEARCH

Silymarin protects spinal cord and cortical cells against oxidative stress and lipopolysaccharide stimulation

(2010) May-Jywan Tsai et al.   NEUROCHEMISTRY INTERNATIONAL

Silibinin: A novel inhibitor of Aβ aggregation

(2010) Fei Yin et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: Involvement of estrogen receptors and oxidative stress

(2010) Tourandokht Baluchnejadmojarad et al.   NEUROSCIENCE LETTERS

Inhibiting NF-κB activation and ROS production are involved in the mechanism of silibinin's protection against D-galactose-induced senescence

(2010) Qiong Wang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Preventive effect of silymarin in cerebral ischemia–reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation

(2010) Yu-Chang Hou et al.   PHYTOMEDICINE

Milk thistle in liver diseases: past, present, future

(2010) Ludovico Abenavoli et al.   PHYTOTHERAPY RESEARCH

Estrogen Receptor Neurobiology and its Potential for Translation into Broad Spectrum Therapeutics for CNS Disorders

(2010) Zoe Hughes et al.   Current Molecular Pharmacology

Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment

(2009) Ping Lu et al.   BEHAVIOURAL BRAIN RESEARCH

Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice

(2009) P Lu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of estrogen receptor beta activity and implications in health and disease

(2009) Elin Swedenborg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Effect of silymarin on biochemical parameters of oxidative stress in aged and young rat brain

(2009) F. Galhardi et al.   FOOD AND CHEMICAL TOXICOLOGY

Silibinin Attenuates Amyloid  25-35 Peptide-Induced Memory Impairments: Implication of Inducible Nitric-Oxide Synthase and Tumor Necrosis Factor-  in Mice

(2009) P. Lu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents

(2009) Anupom Borah et al.   JOURNAL OF PINEAL RESEARCH

l-DOPA-induced 6-hydroxydopamine production in the striata of rodents is sensitive to the degree of denervation

(2009) Anupom Borah et al.   NEUROCHEMISTRY INTERNATIONAL

Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats

(2009) Nagla A. El-Shitany et al.   PHYTOMEDICINE

Estrogens, Brain, and Behavior: Lessons from Knockout Mouse Models

(2009) Rachel Hill et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Silymarin, the Antioxidant Component of Silybum marianum, Prevents Sepsis-Induced Acute Lung and Brain Injury

(2008) Hale Z. Toklu et al.   JOURNAL OF SURGICAL RESEARCH