Neurotrophic function of phytochemicals for neuroprotection in aging and neurodegenerative disorders: modulation of intracellular signaling and gene expression

Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis

(2017) Makoto Naoi et al.   JOURNAL OF NEURAL TRANSMISSION

Type B and A monoamine oxidase and their inhibitors regulate the gene expression of Bcl-2 and neurotrophic factors in human glioblastoma U118MG cells: different signal pathways for neuroprotection by selegiline and rasagiline

(2017) Keiko Inaba-Hasegawa et al.   JOURNAL OF NEURAL TRANSMISSION

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review

(2017) Zi-Ying Wang et al.   PHYTOTHERAPY RESEARCH

Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

(2017) Chao Zhang et al.   Redox Biology

ERK-dependent brain-derived neurotrophic factor regulation by hesperidin in mice exposed to chronic mild stress

(2016) Cheng-Fu Li et al.   BRAIN RESEARCH BULLETIN

Resveratrol reverses chronic restraint stress-induced depression-like behaviour: Involvement of BDNF level, ERK phosphorylation and expression of Bcl-2 and Bax in rats

(2016) Xueer Wang et al.   BRAIN RESEARCH BULLETIN

Rapid synthesis of flavone-based monoamine oxidase (MAO) inhibitors targeting two active sites using click chemistry

(2016) Wei Zhen Jia et al.   Chemical Biology & Drug Design

Ginsenoside Rg1 reverses stress-induced depression-like behaviours and brain-derived neurotrophic factor expression within the prefrontal cortex

(2016) Xiuzhi Zhu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Phytochemicals prevent mitochondrial membrane permeabilization and protect SH-SY5Y cells against apoptosis induced by PK11195, a ligand for outer membrane translocator protein

(2016) Yuqiu Wu et al.   JOURNAL OF NEURAL TRANSMISSION

3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Flavonoid, Ameliorates Corticosterone-Induced Depression-like Behavior and Restores Brain-Derived Neurotrophic Factor Expression, Neurogenesis, and Neuroplasticity in the Hippocampus

(2016) Atsushi Sawamoto et al.   MOLECULES

Effect of curcumin on serum brain-derived neurotrophic factor levels in women with premenstrual syndrome: A randomized, double-blind, placebo-controlled trial

(2016) Hamed Fanaei et al.   NEUROPEPTIDES

The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats

(2016) Z. Liu et al.   NEUROSCIENCE

The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signaling

(2016) Gang Wang et al.   Oncotarget

7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders

(2016) Chaoyang Liu et al.   Translational Neurodegeneration

Red raspberries can improve motor function in aged rats

(2016) Rachel L. Galli et al.   Journal of Berry Research

Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

(2016) Eugenia Morselli et al.   Aging-US

Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults

(2015) Rebecca J Kean et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Monoamine Oxidase Inhibitory Activity of Ferulic Acid Amides: Curcumin-Based Design and Synthesis

(2015) Vishnu N. Badavath et al.   ARCHIV DER PHARMAZIE

Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment

(2015) Giulio Maria Pasinetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The synthesis and evaluation of sesamol and benzodioxane derivatives as inhibitors of monoamine oxidase

(2015) Idalet Engelbrecht et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Polyphenols as mitochondria-targeted anticancer drugs

(2015) Sylwia Gorlach et al.   CANCER LETTERS

The use of plant-derived bioactive compounds to target cancer stem cells and modulate tumor microenvironment

(2015) Francesca Pistollato et al.   FOOD AND CHEMICAL TOXICOLOGY

Neuroprotective and neurorestorative potential of propargylamine derivatives in ageing: focus on mitochondrial targets

(2015) Orit Bar-Am et al.   JOURNAL OF NEURAL TRANSMISSION

Rasagiline and selegiline suppress calcium efflux from mitochondria by PK11195-induced opening of mitochondrial permeability transition pore: a novel anti-apoptotic function for neuroprotection

(2015) Yuqiu Wu et al.   JOURNAL OF NEURAL TRANSMISSION

The mechanisms of action of flavonoids in the brain: Direct versus indirect effects

(2015) Catarina Rendeiro et al.   NEUROCHEMISTRY INTERNATIONAL

Synergistic neuroprotection by epicatechin and quercetin: Activation of convergent mitochondrial signaling pathways

(2015) M. Nichols et al.   NEUROSCIENCE

Ferulic acid attenuates the down-regulation of MEK/ERK/p90RSK signaling pathway in focal cerebral ischemic injury

(2015) Phil-Ok Koh   NEUROSCIENCE LETTERS

How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy

(2015) Yuchen Feng et al.   TRENDS IN CELL BIOLOGY

Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice

(2015) Xi-Jun He et al.   Journal of Toxicologic Pathology

Curcumin hormesis mediates a cross-talk between autophagy and cell death

(2015) N Rainey et al.   Cell Death & Disease

Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis

(2015) Vishnu Nayak Badavath et al.   ACS Medicinal Chemistry Letters

Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells

(2015) Shoujiao Peng et al.   Food & Function

Dietary Patterns, Cognitive Decline, and Dementia: A Systematic Review

(2015) Ondine van de Rest et al.   Advances in Nutrition

Plant-derived flavanol (−)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice

(2015) T P Stringer et al.   Translational Psychiatry

Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms

(2014) Si Qin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The effects of bioactive compounds from plant foods on mitochondrial function: A focus on apoptotic mechanisms

(2014) Tamara Y. Forbes-Hernández et al.   FOOD AND CHEMICAL TOXICOLOGY

Pro-oxidative and Antioxidative Controls and Signaling Modification of Polyphenolic Phytochemicals: Contribution to Health Promotion and Disease Prevention?

(2014) Kai On Chu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

p27 Protein Protects Metabolically Stressed Cardiomyocytes from Apoptosis by Promoting Autophagy

(2014) Xuetao Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress

(2014) Guang Yue Su et al.   JOURNAL OF ETHNOPHARMACOLOGY

3,5,6,7,8,3′,4′-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model

(2014) Satoshi Okuyama et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice

(2014) Sachin P. Patil et al.   NEUROPHARMACOLOGY

Natural Products and Supplements for Geriatric Depression and Cognitive Disorders: An Evaluation of the Research

(2014) Taya Varteresian et al.   Current Psychiatry Reports

Supplemental Substances Derived from Foods as Adjunctive Therapeutic Agents for Treatment of Neurodegenerative Diseases and Disorders

(2014) Gregory E. Bigford et al.   Advances in Nutrition

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

(2014) Hae-Suk Kim et al.   Redox Biology

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects

(2013) Tania Reyes-Izquierdo et al.   BRITISH JOURNAL OF NUTRITION

Herbal Natural Products As a Source of Monoamine Oxidase Inhibitors: A Review

(2013) Dolores Vina et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Revelation in the neuroprotective functions of rasagiline and selegiline: the induction of distinct genes by different mechanisms

(2013) Makoto Naoi et al.   Expert Review of Neurotherapeutics

Ferulic acid: Pharmacological and toxicological aspects

(2013) Cesare Mancuso et al.   FOOD AND CHEMICAL TOXICOLOGY

Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

(2013) Takumi Satoh et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Major Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate, Induces Heme Oxygenase in Rat Neurons and Acts as an Effective Neuroprotective Agent against Oxidative Stress

(2013) Loriana Romeo et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Anthocyanins Protect Against Ethanol-Induced Neuronal Apoptosis via GABAB1 Receptors Intracellular Signaling in Prenatal Rat Hippocampal Neurons

(2013) Shahid ali Shah et al.   MOLECULAR NEUROBIOLOGY

Involvement of α7 nAChR Signaling Cascade in Epigallocatechin Gallate Suppression of β-Amyloid-Induced Apoptotic Cortical Neuronal Insults

(2013) Xijing Zhang et al.   MOLECULAR NEUROBIOLOGY

Intrathecal Epigallocatechin Gallate Treatment Improves Functional Recovery After Spinal Cord Injury by Upregulating the Expression of BDNF and GDNF

(2013) Wei Tian et al.   NEUROCHEMICAL RESEARCH

Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson’s disease in rats

(2013) S.S. Karuppagounder et al.   NEUROSCIENCE

Reversal of dopamine neurons and locomotor ability degeneration in aged rats with smilagenin

(2013) J. Li et al.   NEUROSCIENCE

Effects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brain

(2013) Sara De Nicoló et al.   NUTRITION

Neuroprotective effects of resveratrol and epigallocatechin gallate polyphenols are mediated by the activation of protein kinase C gamma

(2013) Caroline Menard et al.   Frontiers in Cellular Neuroscience

Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF

(2012) Laura L. Hurley et al.   BEHAVIOURAL BRAIN RESEARCH

Activations of GABAergic signaling, HSP70 and MAPK cascades are involved in baicalin's neuroprotection against gerbil global ischemia/reperfusion injury

(2012) Jiong Dai et al.   BRAIN RESEARCH BULLETIN

Monoamine Oxidase Inhibitors as Neuroprotective Agents in Age-Dependent Neurodegenerative Disorders

(2012) Makoto Naoi et al.   CURRENT PHARMACEUTICAL DESIGN

Evaluation of the Inhibitory Effects of Quercetin-Related Flavonoids and Tea Catechins on the Monoamine Oxidase-A Reaction in Mouse Brain Mitochondria

(2012) Yauhen Bandaruk et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

‘‘70th Birthday Professor Riederer’’ Induction of glial cell line-derived and brain-derived neurotrophic factors by rasagiline and (−)deprenyl: a way to a disease-modifying therapy?

(2012) Wakako Maruyama et al.   JOURNAL OF NEURAL TRANSMISSION

Genistein Inhibits Aβ25–35 –Induced Neurotoxicity in PC12 Cells via PKC Signaling Pathway

(2012) Sijing Luo et al.   NEUROCHEMICAL RESEARCH

Naringin Treatment Improves Functional Recovery by Increasing BDNF and VEGF Expression, Inhibiting Neuronal Apoptosis After Spinal Cord Injury

(2012) Wei Rong et al.   NEUROCHEMICAL RESEARCH

Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson’s disease

(2012) A. Anandhan et al.   NEUROSCIENCE

Smilagenin attenuates beta amyloid (25–35)-induced degeneration of neuronal cells via stimulating the gene expression of brain-derived neurotrophic factor

(2012) R. Zhang et al.   NEUROSCIENCE

Scutellarin protects against Aβ-induced learning and memory deficits in rats: involvement of nicotinic acetylcholine receptors and cholinesterase

(2011) Li-li Guo et al.   ACTA PHARMACOLOGICA SINICA

Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications

(2011) Brahma N. Singh et al.   BIOCHEMICAL PHARMACOLOGY

Lipophilic Caffeic and Ferulic Acid Derivatives Presenting Cytotoxicity against Human Breast Cancer Cells

(2011) Teresa L. Serafim et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

(2011) Robert J. Williams et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role for monoaminergic systems in the antidepressant-like effect of ethanol extracts from Hemerocallis citrina

(2011) Lan Gu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-Parkinsonian drug discovery from herbal medicines: What have we got from neurotoxic models?

(2011) Ju-Xian Song et al.   JOURNAL OF ETHNOPHARMACOLOGY

Curcumin prevents corticosterone-induced neurotoxicity and abnormalities of neuroplasticity via 5-HT receptor pathway

(2011) Ying Xu et al.   JOURNAL OF NEUROCHEMISTRY

Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells

(2011) Seung-Hwan Kwon et al.   NEUROCHEMISTRY INTERNATIONAL

Protective effects of lycopene against amyloid β-induced neurotoxicity in cultured rat cortical neurons

(2011) Mingyue Qu et al.   NEUROSCIENCE LETTERS

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors

(2010) J. Reniers et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ginsenosides Rb1 and Rg1 promote proliferation and expression of neurotrophic factors in primary Schwann cell cultures

(2010) Wei Liang et al.   BRAIN RESEARCH

Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor proNGF expression in a rat model of diabetes

(2010) M. M. H. Al-Gayyar et al.   DIABETOLOGIA

Curcumin attenuates the effects of transport stress on serum cortisol concentration, hippocampal NO production, and BDNF expression in the pig

(2010) S. Wei et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Ginkgolide B protects hippocampal neurons from apoptosis induced by beta-amyloid 25–35 partly via up-regulation of brain-derived neurotrophic factor

(2010) Qian Xiao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

(2010) S.-W. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repairing the parkinsonian brain with neurotrophic factors

(2010) Liviu Aron et al.   TRENDS IN NEUROSCIENCES

Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: A demonstration of the ambivalent redox character of polyphenols

(2009) Umberto De Marchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment

(2009) Robert Krikorian et al.   BRITISH JOURNAL OF NUTRITION

Protective Effects of Resveratrol and Quercetin Against MPP+ -Induced Oxidative Stress Act by Modulating Markers of Apoptotic Death in Dopaminergic Neurons

(2009) Julie Bournival et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies

(2009) Anna L. Macready et al.   Genes and Nutrition

Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways

(2009) Quan-Gui Gao et al.   JOURNAL OF NEUROCHEMISTRY

Naturally occurring phytochemicals for the prevention of Alzheimer’s disease

(2009) Jiyoung Kim et al.   JOURNAL OF NEUROCHEMISTRY

Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress

(2009) Alexander M. Wolf et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice

(2009) Yan Hou et al.   NEUROPHARMACOLOGY

Catalpol ameliorates beta amyloid–induced degeneration of cholinergic neurons by elevating brain-derived neurotrophic factors

(2009) Z. Wang et al.   NEUROSCIENCE

Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons

(2009) Rui Wang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

“Killing the Blues”: A role for cellular suicide (apoptosis) in depression and the antidepressant response?

(2009) Declan P. McKernan et al.   PROGRESS IN NEUROBIOLOGY

Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2

(2008) Paula M. Brito et al.   APOPTOSIS

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Role of glial cell derived neurotrophic factor in the protective effect of smilagenin on rat mesencephalic dopaminergic neurons damaged by MPP+

(2008) Yongfang Zhang et al.   FEBS LETTERS

Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells

(2008) Yasutaka Ikeda et al.   JOURNAL OF NEUROCHEMISTRY

A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction

(2008) Takahiro Shibata et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial Medicine for Aging and Neurodegenerative Diseases

(2008) P. Hemachandra Reddy   NEUROMOLECULAR MEDICINE

GABAA receptors: Subtypes provide diversity of function and pharmacology

(2008) Richard W. Olsen et al.   NEUROPHARMACOLOGY

Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson's disease model of SH-SY5Y cells

(2007) Kazuhiro Nakaso et al.   NEUROSCIENCE LETTERS