Tauroursodeoxycholate—Bile Acid with Chaperoning Activity: Molecular and Cellular Effects and Therapeutic Perspectives

The Role of Tauroursodeoxycholic Acid on Dedifferentiation of Vascular Smooth Muscle Cells by Modulation of Endoplasmic Reticulum Stress and as an Oral Drug Inhibiting In-Stent Restenosis

(2019) Hangqi Luo et al.   CARDIOVASCULAR DRUGS AND THERAPY

The Role of the ER-Induced UPR Pathway and the Efficacy of Its Inhibitors and Inducers in the Inhibition of Tumor Progression

(2019) Anna Walczak et al.   Oxidative Medicine and Cellular Longevity

Large-scale production of tauroursodeoxycholic acid products through fermentation optimization of engineered Escherichia coli cell factory

(2019) Yingpeng Xu et al.   Microbial Cell Factories

Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer

(2019) Sandhya Chipurupalli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TUDCA-Treated Mesenchymal Stem Cells Protect against ER Stress in the Hippocampus of a Murine Chronic Kidney Disease Model

(2019) Jun Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual Role of Bile Acids on the Biliary Epithelium: Friend or Foe?

(2019) Leonardo Baiocchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tudca Ameliorates Liver Injury Via Activation of SIRT1–FXR Signaling in a Rat Hemorrhagic Shock Model

(2019) Silei Sun et al.   SHOCK

The Bile Acid TUDCA Improves Beta-Cell Mass and Reduces Insulin Degradation in Mice With Early-Stage of Type-1 Diabetes

(2019) Gabriela Alves Bronczek et al.   Frontiers in Physiology

TUDCA-treated chronic kidney disease-derived hMSCs improve therapeutic efficacy in ischemic disease via PrPC

(2019) Yeo Min Yoon et al.   Redox Biology

The Biosynthesis, Signaling, and Neurological Functions of Bile Acids

(2019) Yoshimitsu Kiriyama et al.   Biomolecules

TUDCA attenuates intestinal injury and inhibits endoplasmic reticulum stress-mediated intestinal cell apoptosis in necrotizing enterocolitis

(2019) Peng Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Aberrant MUC1 accumulation in salivary glands of Sjögren’s syndrome patients is reversed by TUDCA in vitro

(2019) Isabel Castro et al.   RHEUMATOLOGY

Tauroursodeoxycholic acid alleviates hepatic ischemia reperfusion injury by suppressing the function of Kupffer cells in mice

(2018) Xuesong Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in mice with non-alcoholic fatty liver disease

(2018) Weijun Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bile acids stimulate cholangiocyte fluid secretion by activation of transmembrane member 16A Cl− channels

(2018) Qin Li et al.   HEPATOLOGY

Tauroursodeoxycholic Acid Protects against the Effects of P-Cresol-Induced Reactive Oxygen Species via the Expression of Cellular Prion Protein

(2018) Seung Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silica nanoparticle-induced oxidative stress and mitochondrial damage is followed by activation of intrinsic apoptosis pathway in glioblastoma cells

(2018) Magdalena Kusaczuk et al.   International Journal of Nanomedicine

Biochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles

(2018) Stewart F. Graham et al.   JOURNAL OF PROTEOME RESEARCH

Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease

(2018) Alexandra Isabel Rosa et al.   MOLECULAR NEUROBIOLOGY

Tauroursodeoxycholic acid (TUDCA) alleviates endoplasmic reticulum stress of nuclear donor cells under serum starvation

(2018) Ying Zhang et al.   PLoS One

Ursodeoxycholic acid attenuates 5‑fluorouracil‑induced mucositis in a rat model

(2018) Seung Kim et al.   Oncology Letters

Anti-inflammatory effect of Tauroursodeoxycholic acid in RAW 264.7 macrophages, Bone marrow-derived macrophages, BV2 microglial cells, and spinal cord injury

(2018) Seong Jun Kim et al.   Scientific Reports

Preparation and toxicity evaluation of a novel nattokinase-tauroursodeoxycholate complex

(2018) Rui Feng et al.   Asian Journal of Pharmaceutical Sciences

Effect of 4-Phenylbutyric Acid and Tauroursodeoxycholic Acid on Magnesium and Calcium Metabolism in Streptozocin-Induced Type 1 Diabetic Mice

(2018) Qi Zhou et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Tauroursodeoxycholic acid (TUDCA) abolishes chronic high salt-induced renal injury and inflammation

(2018) Carmen De Miguel et al.   Acta Physiologica

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

(2018) Siamak MahmoudianDehkordi et al.   Alzheimers & Dementia

Tauroursodeoxycholic acid attenuates colitis-associated colon cancer by inhibiting nuclear factor kappaB signaling

(2018) Young Hoon Kim et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway

(2018) Huan Yu et al.   ONCOLOGY REPORTS

Bile Acids and Their Derivatives as Potential Modifiers of Drug Release and Pharmacokinetic Profiles

(2018) Nebojša Pavlović et al.   Frontiers in Pharmacology

Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease

(2017) Sara Moreira et al.   EXPERIMENTAL NEUROLOGY

Effect of tauroursodeoxycholic acid on PUFA levels and inflammation in an animal and cell model of hepatic endoplasmic reticulum stress

(2017) M Aslan et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis

(2017) Annelies Paridaens et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Farnesoid X Receptor Agonism Protects against Diabetic Tubulopathy: Potential Add-On Therapy for Diabetic Nephropathy

(2017) Andi Marquardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tauroursodeoxycholic Acid Reduces Arterial Stiffness and Improves Endothelial Dysfunction in Type 2 Diabetic Mice

(2017) Micah L. Battson et al.   JOURNAL OF VASCULAR RESEARCH

Treatment of primary biliary cholangitis ursodeoxycholic acid non-responders: A systematic review

(2017) Duminda Suraweera et al.   LIVER INTERNATIONAL

Tauroursodeoxycholic acid inhibits TNF-α-induced lipolysis in 3T3-L1 adipocytes via the IRE-JNK-perilipin-A signaling pathway

(2017) Wenyan Xia et al.   Molecular Medicine Reports

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

Administration of Tauroursodeoxycholic Acid Attenuates Early Brain Injury via Akt Pathway Activation

(2017) Dongdong Sun et al.   Frontiers in Cellular Neuroscience

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease

(2017) Gargi Ganguly et al.   Drug Design Development and Therapy

Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice

(2017) Jean Franciesco Vettorazzi et al.   Scientific Reports

Protein Quality Control by Molecular Chaperones in Neurodegeneration

(2017) Aaron Ciechanover et al.   Frontiers in Neuroscience

Chemical chaperone, TUDCA unlike PBA, mitigates protein aggregation efficiently and resists ER and non-ER stress induced HepG2 cell death

(2017) Jagadeesh Kumar Uppala et al.   Scientific Reports

Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy

(2016) Nathalie Launay et al.   ACTA NEUROPATHOLOGICA

Effect of a chemical chaperone, tauroursodeoxycholic acid, on HDM-induced allergic airway disease

(2016) Jalahalli M. Siddesha et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The role of endoplasmic reticulum stress in neurodegenerative disease

(2016) Chunchen Xiang et al.   APOPTOSIS

Substitutes for Bear Bile for the Treatment of Liver Diseases: Research Progress and Future Perspective

(2016) Sha Li et al.   Evidence-based Complementary and Alternative Medicine

Effects of bile acids on neurological function and disease

(2016) Matthew McMillin et al.   FASEB JOURNAL

A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis

(2016) Hong Ma et al.   MEDICINE

The bile acid TUDCA increases glucose-induced insulin secretion via the cAMP/PKA pathway in pancreatic beta cells

(2016) Jean Franciesco Vettorazzi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

TGFβ Contributes to the Anti-inflammatory Effects of Tauroursodeoxycholic Acid on an Animal Model of Acute Neuroinflammation

(2016) Natalia Yanguas-Casás et al.   MOLECULAR NEUROBIOLOGY

Tauroursodeoxycholic acid reduces the invasion of MDA-MB-231 cells by modulating matrix metalloproteinases 7 and 13

(2016) Ga-Young Park et al.   Oncology Letters

Bile Acids in Neurodegenerative Disorders

(2016) Hayley D. Ackerman et al.   Frontiers in Aging Neuroscience

Epigenetics: from the past to the present

(2016) Nubia Andrea Villota-Salazar et al.   Frontiers in Life Science

Tauroursodeoxycholic acid prevents stress induced aggregation of proteins in vitro and promotes PERK activation in HepG2 cells

(2015) Amina R. Gani et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Effect of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Metabolism of Copper and Zinc in Type 1 Diabetic Mice Model

(2015) Qi Zhou et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes

(2015) Ana Paula Arruda et al.   Cell Metabolism

Phenylbutyric Acid: Simple Structure - Multiple Effects

(2015) Magdalena Kusaczuk et al.   CURRENT PHARMACEUTICAL DESIGN

The TUDCA trial - innovative trial designs for amyotrophic lateral sclerosis drugs?

(2015) A. C. Ludolph   EUROPEAN JOURNAL OF NEUROLOGY

Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

(2015) A. E. Elia et al.   EUROPEAN JOURNAL OF NEUROLOGY

Tauroursodeoxycholic acid suppresses endoplasmic reticulum stress in the chondrocytes of patients with osteoarthritis

(2015) CHAO LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Critical Role of Endoplasmic Reticulum Stress in Cognitive Impairment Induced by Microcystin-LR

(2015) Fei Cai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease

(2015) Leonardo M. Cortez et al.   JOURNAL OF VIROLOGY

Neuroprotective Effect of Tauroursodeoxycholic Acid on N-Methyl-D-Aspartate-Induced Retinal Ganglion Cell Degeneration

(2015) Violeta Gómez-Vicente et al.   PLoS One

Glycolipid Metabolism Disorder in the Liver of Obese Mice Is Improved by TUDCA via the Restoration of Defective Hepatic Autophagy

(2015) Qinyue Guo et al.   International Journal of Endocrinology

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

(2015) Yves-Paul Vandewynckel et al.   Oncotarget

Classification of Chemical Chaperones Based on Their Effect on Protein Folding Landscapes

(2014) Rohan Dandage et al.   ACS Chemical Biology

Tauroursodeoxycholic Acid Attenuates Progression of Steatohepatitis in Mice Fed a Methionine–Choline-Deficient Diet

(2014) Eun-Ju Cho et al.   DIGESTIVE DISEASES AND SCIENCES

Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects

(2014) Agustina Noailles et al.   Journal of Neuroinflammation

Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation

(2014) Natalia Yanguas-Casás et al.   Journal of Neuroinflammation

The therapeutic potential of chemical chaperones in protein folding diseases

(2014) Leonardo Cortez et al.   Prion

Therapeutic uses of animal biles in traditional Chinese medicine: An ethnopharmacological, biophysical chemical and medicinal review

(2014) David Q-H Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Sodium tauroursodeoxycholate prevents paraquat-induced cell death by suppressing endoplasmic reticulum stress responses in human lung epithelial A549 cells

(2013) Tomohiro Omura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis and Evaluation of Water-Soluble Prodrugs of Ursodeoxycholic Acid (UDCA), an Anti-apoptotic Bile Acid

(2013) Peter I. Dosa et al.   ChemMedChem

Molecular Chaperone ORP150 in ER Stress–related Diseases

(2013) Magdalena Kusaczuk et al.   CURRENT PHARMACEUTICAL DESIGN

β1 integrin is a long-sought sensor for tauroursodeoxycholic acid

(2013) Ulrich Beuers   HEPATOLOGY

Efficacy and safety of tauroursodeoxycholic acid in the treatment of liver cirrhosis: A double-blind randomized controlled trial

(2013) Xiao-li Pan et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose

(2013) J.M. Gaspar et al.   NEUROSCIENCE

Prenatal Ethanol Exposure Causes Glucose Intolerance with Increased Hepatic Gluconeogenesis and Histone Deacetylases in Adult Rat Offspring: Reversal by Tauroursodeoxycholic Acid

(2013) Xing-Hai Yao et al.   PLoS One

Autophagy Attenuates Diabetic Glomerular Damage through Protection of Hyperglycemia-Induced Podocyte Injury

(2013) Li Fang et al.   PLoS One

Restoration of the Unfolded Protein Response in Pancreatic   Cells Protects Mice Against Type 1 Diabetes

(2013) F. Engin et al.   Science Translational Medicine

Bile Acids Acutely Stimulate Insulin Secretion of Mouse  -Cells via Farnesoid X Receptor Activation and KATP Channel Inhibition

(2012) M. Dufer et al.   DIABETES

Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes

(2012) E. Panzhinskiy et al.   DIABETOLOGIA

Ursodeoxycholic acid for nonalcoholic steatohepatitis

(2012) Sheng-di Wu et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Tauroursodeoxycholate, a Chemical Chaperone, Prevents Palmitate-induced Apoptosis in Pancreatic β-cells by Reducing ER Stress

(2012) Q. Zhu et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Amelioration of Glucolipotoxicity-Induced Endoplasmic Reticulum Stress by a “Chemical Chaperone” in Human THP-1 Monocytes

(2012) Raji Lenin et al.   Experimental Diabetes Research

α5β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes

(2012) Holger Gohlke et al.   HEPATOLOGY

A Novel Role for Epidermal Growth Factor Receptor Tyrosine Kinase and Its Downstream Endoplasmic Reticulum Stress in Cardiac Damage and Microvascular Dysfunction in Type 1 Diabetes Mellitus

(2012) Maria Galán et al.   HYPERTENSION

Molecular Mechanisms of Ursodeoxycholic Acid Toxicity & Side Effects: Ursodeoxycholic Acid Freezes Regeneration & Induces Hibernation Mode

(2012) Magd A. Kotb   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apolipoprotein E4 Impairs Macrophage Efferocytosis and Potentiates Apoptosis by Accelerating Endoplasmic Reticulum Stress

(2012) James G. Cash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral Solubilized Ursodeoxycholic Acid Therapy in Amyotrophic Lateral Sclerosis: A Randomized Cross-Over Trial

(2012) Ju-Hong Min et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice

(2012) Ana F. Nunes et al.   MOLECULAR NEUROBIOLOGY

Tauroursodeoxycholic Acid Prevents MPTP-Induced Dopaminergic Cell Death in a Mouse Model of Parkinson’s Disease

(2012) M. Castro-Caldas et al.   MOLECULAR NEUROBIOLOGY

Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice

(2012) Adrian C. Lo et al.   NEUROBIOLOGY OF DISEASE

Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: An overview of their mechanisms of action

(2012) Raoul Poupon   Clinics and Research in Hepatology and Gastroenterology

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis

(2011) Ersin Seyhun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Steroid and Ursodesoxycholic Acid Combination Therapy in Severe Drug-Induced Liver Injury

(2011) Alexander Wree et al.   DIGESTION

In PSC with Colitis Treated with UDCA, Most Colonic Carcinomas Develop in the First Years After the Start of Treatment

(2011) G. Rudolph et al.   DIGESTIVE DISEASES AND SCIENCES

The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

(2011) Wagner S. da-Silva et al.   FEBS LETTERS

Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

(2011) Elaine Studer et al.   HEPATOLOGY

Tauroursodeoxycholic Acid (TUDCA) Protects Photoreceptors from Cell Death after Experimental Retinal Detachment

(2011) Dimosthenis Mantopoulos et al.   PLoS One

Ursodeoxycholic acid suppresses mitochondria-dependent programmed cell death induced by sodium nitroprusside in SH-SY5Y cells

(2011) Hong Sung Chun et al.   TOXICOLOGY

Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress

(2010) Yeon Yi Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Safety, Tolerability, and Cerebrospinal Fluid Penetration of Ursodeoxycholic Acid in Patients With Amyotrophic Lateral Sclerosis

(2010) Gareth J. Parry et al.   CLINICAL NEUROPHARMACOLOGY

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

Rescue of Cystathionine β-Synthase (CBS) Mutants with Chemical Chaperones

(2010) Tomas Majtan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis

(2010) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction

(2010) Asli F. Ceylan-Isik et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Constituents of bile, bilirubin and TUDCA, protect against oxidative stress-induced retinal degeneration

(2010) Brian C. Oveson et al.   JOURNAL OF NEUROCHEMISTRY

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus

(2009) Alena Viktorínová et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Converging concepts of protein folding in vitro and in vivo

(2009) F Ulrich Hartl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Bear bile: dilemma of traditional medicinal use and animal protection

(2009) Yibin Feng et al.   Journal of Ethnobiology and Ethnomedicine

The role of membrane cholesterol in determining bile acid cytotoxicity and cytoprotection of ursodeoxycholic acid

(2008) Yong Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

(2008) G. Boden et al.   DIABETES

Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC -/PKA-dependent mechanism in rat liver

(2008) R Wimmer et al.   GUT

Endoplasmic Reticulum Stress Markers Are Associated with Obesity in Nondiabetic Subjects

(2008) Neeraj K. Sharma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

High dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis is safe and effective

(2008) Susan N. Cullen et al.   JOURNAL OF HEPATOLOGY

Protein Misfolding in Conformational Disorders: Rescue of Folding Defects and Chemical Chaperoning

(2008) Paula Leandro et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease

(2008) Rita M. Ramalho et al.   TRENDS IN MOLECULAR MEDICINE

Tauroursodeoxycholic Acid Partially Prevents Apoptosis Induced by 3-Nitropropionic Acid

(2003) Cecilia M. P. Rodrigues et al.   JOURNAL OF NEUROCHEMISTRY