Article
Biochemistry & Molecular Biology
Magdalena Kusaczuk, Monika Naumowicz, Rafal Kretowski, Bartosz Cukierman, Marzanna Cechowska-Pasko
Summary: In this study, TUDCA showed potential in alleviating ER stress in chondrocytes, but was not effective in preventing apoptosis in both normoxic and hypoxic conditions. However, co-treatment with TUDCA was able to alleviate inflammatory response induced by IL-1 beta and enhance Col II alpha expression in normoxic conditions. Further analyses are needed to confirm TUDCA's potential as a candidate in OA therapy.
Article
Geriatrics & Gerontology
Lixing Feng, Wanli Zhang, Qiang Shen, Chunxiao Miao, Lijuan Chen, Yiwei Li, Xiaofan Gu, Meng Fan, Yushui Ma, Hui Wang, Xuan Liu, Xiongwen Zhang
Summary: The study revealed that cancer cachexia in mice involved dysregulation of bile acid metabolism, including decreased synthesis and increased conjugation of bile acids. Dysbiosis in gut microbiota also played a role in altering bile acid metabolism. The use of agents like TUDCA showed promising results in alleviating symptoms of cancer cachexia in mice.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Biochemistry & Molecular Biology
Michal J. Sabat, Anna M. Wisniewska-Becker, Michal Markiewicz, Katarzyna M. Marzec, Jakub Dybas, Justyna Furso, Pawel Pabisz, Mariusz Duda, Anna M. Pawlak
Summary: TUDCA is a hydrophilic bile acid that has been used as a therapeutic compound in traditional Chinese medicine. It has gained interest as a neuroprotective agent and has antioxidant activity, as well as stabilizing effects on mitochondrial and plasma membranes. Additionally, TUDCA induces slight changes in the polarity and fluidity of model membranes.
Article
Biochemistry & Molecular Biology
Sunje Kim, Seong Eun Lee, Shinae Yi, Sangmi Jun, Yoon-Sun Yi, Harsha Nagar, Cuk-Seong Kim, Chungmin Shin, Min-Kyung Yeo, Yea Eun Kang, Sang-Ha Oh
Summary: The study identified that mitochondrial dysfunction and dysregulated endoplasmic reticulum stress signaling play a role in human keloid formation, and that treatment with tauroursodeoxycholic acid (TUDCA) shows potential in reducing scar formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Reproductive Biology
Naomi Dicks, Karina Gutierrez, Luke Currin, Mariana P. de Macedo, Werner G. Glanzner, Rafael G. Mondadori, Marek Michalak, Luis B. Agellon, Vilceu Bordignon
Summary: Impaired energy and nutrient homeostasis conditions like diabetes and obesity are associated with infertility. The natural bile acid tauroursodeoxycholic acid reduces endoplasmic reticulum stress and rescues developmentally incompetent embryos, and acts via the Takeda-G-protein-receptor-5 to alleviate nuclear stress in embryos. This study suggests that Takeda-G-protein-receptor-5 signaling pathways play a crucial role in linking the unfolded protein response and genome damage response in embryos, and could be a potential target for mitigating fertility issues caused by nutrient excess-associated stress.
BIOLOGY OF REPRODUCTION
(2021)
Article
Immunology
Changsheng Yan, Yuan Ma, He Li, Jitao Cui, Xiaoyu Guo, Gang Wang, Liang Ji
Summary: The study aimed to investigate the role of endoplasmic reticulum stress (ERS) in promoting caspase-1-dependent pancreatic acinar cell pyroptosis via the protein kinase R-like ER kinase (PERK) pathway to aggravate acute pancreatitis (AP). Findings showed that ERS enhances caspase-1-dependent pyroptosis and pyroptotic injury through the PERK pathway, exacerbating AP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Israelle Netto Freitas, Joel Alves da Silva Jr, Kenia Moreno de Oliveira, Bruna Lourenconi Alves, Thiago Dos Reis Araujo, Joao Paulo Camporez, Everardo Magalhaes Carneiro, Ana Paula Davel
Summary: Adipose tissue, an organ with metabolic and endocrine activity, undergoes morphological, functional, and molecular changes during obesity. The ER stress inhibitor TUDCA has shown therapeutic potential in minimizing adipose tissue dysfunction and metabolic alterations associated with obesity. Specifically, TUDCA has been demonstrated to inhibit ER stress, inflammation, and apoptosis in adipocytes, and may have cardiovascular protective effects through its influence on perivascular adipose tissue (PVAT) function and adiponectin release.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Alberto Albanese, Albert Christian Ludolph, Christopher J. J. McDermott, Philippe Corcia, Philip Van Damme, Leonard H. Van den Berg, Orla Hardiman, Gilberto Rinaldi, Nicola Vanacore, Brian Dickie
Summary: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with limited treatment options, riluzole being the only approved drug in Europe. The TUDCA-ALS trial is a multinational study to evaluate the disease-modifying effects of TUDCA in ALS.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Manashi Priyadarshini, Santanu Maji, Sabindra K. Samal, Rachna Rath, Jiong Li, Swadesh K. Das, Luni Emdad, Chanakya Nath Kundu, Paul B. Fisher, Rupesh Dash
Summary: The study found that SARI expression is significantly lower in oral squamous cell carcinoma tissues compared to normal adjacent tissues. Ectopic expression of SARI induces cancer-specific cell death in OSCC cell lines and inhibits the expression of zinc finger protein GLI1 through induction of endoplasmic reticulum stress. The data provides a link between ER stress induction and inhibition of the GLI1/Hedgehog signaling pathway with the tumor suppressive activity of SARI in OSCC.
Article
Medicine, Research & Experimental
Lele Cheng, Tao Chen, Manyun Guo, Peining Liu, Xiangrui Qiao, Yuanyuan Wei, Jianqing She, Bolin Li, Wen Xi, Juan Zhou, Zuyi Yuan, Yue Wu, Junhui Liu
Summary: Recent studies have shown changes in bile acid metabolite composition in metabolic disorders, with glycoursodeoxycholic acid (GUDCA) being decreased in hyperglycemic patients. GUDCA supplementation alleviated ER stress and apoptosis, stabilizing calcium homeostasis, and ameliorated insulin resistance and hepatic steatosis in HFD-fed mice. This suggests that GUDCA may be a potential treatment option for metabolic disorders by inhibiting ER stress.
Article
Immunology
Hong-Lei Wang, Fen-Qiao Chen, Li-Juan Wu
Summary: The study found that ephedrine has therapeutic effects on the development of chronic obstructive pulmonary disease (COPD). It can alleviate cell death, oxidative stress, and inflammatory response by reducing reactive oxygen species (ROS) levels. Additionally, ephedrine can suppress endoplasmic reticulum (ER) stress signaling and mitigate cigarette smoke-induced damage to cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zueleyha Doganyigit, Asli Okan, Enes Akyuz, Seher Yilmaz, Sukru Ates, Serpil Taheri, Zeynep Yilmaz, Mohd. Farooq Shaikh
Summary: The study found that TUDCA and 4-PBA treatment can suppress the process of endoplasmic reticulum stress, reduce oxidative stress and apoptosis, and protect neurons in epileptic seizures.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gopalakrishna Ramachandran, Shivranjani C. Moharir, Tirumalai R. Raghunand, Ghanshyam Swarup
Summary: The autophagy receptor Optineurin/Optn plays a physiological role in the endoplasmic reticulum stress response, regulating cell death and signaling pathways. Optn deficiency results in higher cell death and caspase-3 activation, while upregulating transcript levels of genes in the IRE1-XBP1 and PERK-ATF4 pathways. This suggests that Optn modulation provides protection against ER stress-induced cell death.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Himanshu Sankrityayan, Vishwadeep Shelke, Ajinath Kale, Anil Bhanudas Gaikwad
Summary: This study evaluated the potential and underlying molecular mechanism of the bile acid tauroursodeoxycholic acid (TUDCA) as a monotherapy and as an add-on therapy to telmisartan for treating diabetic kidney disease (DKD). The results showed that the addition of TUDCA to telmisartan treatment was more effective in restoring renal function and suppressing apoptotic and fibrotic signaling compared to monotherapies. This suggests that TUDCA, traditionally used in Chinese medicine, could be a potential renoprotective compound when used in combination with telmisartan.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Xiaoying Liu, Mahmoud Khalafalla, Chuhan Chung, Yevgeniy Gindin, Susan Hubchak, Brian LeCuyer, Alyssa Kriegermeier, Danny Zhang, Wei Qiu, Xianzhong Ding, Deyu Fang, Richard Green
Summary: The hepatic XBP1 pathway is activated in older Fxr-/- mice and has a protective role.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Monika Kloza, Marta Baranowska-Kuczko, Marek Toczek, Magdalena Kusaczuk, Olga Sadowska, Irena Kasacka, Hanna Kozlowska
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Monika Naumowicz, Magdalena Kusaczuk, Marcin Andrzej Kruszewski, Miroslav Gal, Rafal Kretowski, Marzanna Cechowska-Pasko, Joanna Kotynska
BIOORGANIC CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Marcin Andrzej Kruszewski, Joanna Kotynska, Magdalena Kusaczuk, Miroslav Gal, Monika Naumowicz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Correction
Biochemistry & Molecular Biology
Monika Naumowicz, Magdalena Kusaczuk, Marcin Andrzej Kruszewski, Miroslav Gal, Rafal Kretowski, Marzanna Cechowska-Pasko, Joanna Kotynska
BIOORGANIC CHEMISTRY
(2020)
Article
Peripheral Vascular Disease
Marta Baranowska-Kuczko, Hanna Kozlowska, Monika Kloza, Olga Sadowska, Miroslaw Kozlowski, Magdalena Kusaczuk, Irena Kasacka, Barbara Malinowska
JOURNAL OF HYPERTENSION
(2020)
Article
Biochemistry & Molecular Biology
Monika Naumowicz, Magdalena Kusaczuk, Marcin Zajac, Miroslav Gal, Joanna Kotynska
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Monika Naumowicz, Marcin Zajac, Magdalena Kusaczuk, Miroslav Gal, Joanna Kotynska
Article
Biochemistry & Molecular Biology
Magdalena Kusaczuk, Monika Naumowicz, Rafal Kretowski, Bartosz Cukierman, Marzanna Cechowska-Pasko
Summary: In this study, TUDCA showed potential in alleviating ER stress in chondrocytes, but was not effective in preventing apoptosis in both normoxic and hypoxic conditions. However, co-treatment with TUDCA was able to alleviate inflammatory response induced by IL-1 beta and enhance Col II alpha expression in normoxic conditions. Further analyses are needed to confirm TUDCA's potential as a candidate in OA therapy.
Article
Biochemistry & Molecular Biology
Rafal Kretowski, Magdalena Kusaczuk, Monika Naumowicz, Marzanna Cechowska-Pasko
Summary: Research indicates that silica nanoparticles exhibit anticancer effects on glioblastoma cells by inducing apoptosis or necrosis, but these effects are highly dependent on cell type, nanoparticle size, and dosage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Kusaczuk, Rafal Kretowski, Monika Naumowicz, Anna Stypulkowska, Marzanna Cechowska-Pasko
Summary: The study investigated the interaction of dietary flavonoid quercetin with human glioblastoma cell lines. The results showed that quercetin induced apoptosis and cell death through activation of the intrinsic pathway of apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hanna Kozlowska, Barbara Malinowska, Marta Baranowska-Kuczko, Magdalena Kusaczuk, Milosz Nesterowicz, Miroslaw Kozlowski, Christa E. Mueller, Katarzyna Kiec-Kononowicz, Eberhard Schlicker
Summary: The GPR18 receptor protein, found in the heart and vasculature, plays a functional role in the cardiovascular system. New GPR18 agonists, PSB-MZ-1415 and PSB-MZ-1440, were shown to relax human pulmonary arteries, while the GPR18 antagonist PSB-CB-27 inhibited this effect. The activity of GPR18 appeared to be lower in male patients, smokers, and patients with hypercholesterolemia, potentially making it a new target for the treatment of pulmonary arterial hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Marta Baranowska-Kuczko, Hanna Kozlowska, Monika Kloza, Magdalena Kusaczuk, Ewa Harasim-Symbor, Michal Biernacki, Irena Kasacka, Barbara Malinowska
Summary: The study showed that chronic cannabidiol (CBD) treatment has vascular protective effects in hypertensive rats, improving endothelial function and vasodilation, partly through influencing the endocannabinoid system.
Article
Multidisciplinary Sciences
Monika Naumowicz, Magdalena Kusaczuk, Marcin Zajac, Agata Jablonska-Trypuc, Agnieszka Miklosz, Miroslav Gal, Mateusz Worobiczuk, Joanna Kotynska
Summary: Caffeic acid, a phenolic compound synthesized by plants, has been found to have anticancer activity. The study reveals the biophysical interactions between caffeic acid and cancer cells or biomimetic membranes, suggesting its potential as a cytostatic agent in cancer treatment.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Agnieszka Miklosz, Bartlomiej Lukaszuk, Elzbieta Supruniuk, Kamil Grubczak, Aleksandra Starosz, Magdalena Kusaczuk, Monika Naumowicz, Adrian Chabowski
Summary: This study investigated the phenotypic and metabolic characteristics of adipocytes derived from ADMSCs in lean and obese postmenopausal women. The results showed that obesity influenced the functionality of progenitor adipocytes, suggesting a memory effect, and there were pronounced changes in the adipocytes derived from different depots.
Meeting Abstract
Biochemistry & Molecular Biology
M. Kusaczuk, E. Tovar Ambel, P. Martin Cabrera, K. Bhutia, O. Gutierrez Jimenez, G. Velasco