Immunological pathogenesis and treatment of systemic lupus erythematosus

Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus

(2018) Takayuki Katsuyama et al.   Frontiers in Immunology

NETosis: At the crossroads of rheumatoid arthritis, lupus, and vasculitis

(2017) Jean-Marie Berthelot et al.   JOINT BONE SPINE

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

New insights into the immunopathogenesis of systemic lupus erythematosus

(2016) George C. Tsokos et al.   Nature Reviews Rheumatology

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

(2016) Paula Giselle Czaikoski et al.   PLoS One

A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE)

(2015) Kenneth C Kalunian et al.   ANNALS OF THE RHEUMATIC DISEASES

The role of neutrophils in the pathogenesis of systemic lupus erythematosus

(2015) Carolyne K. Smith et al.   CURRENT OPINION IN RHEUMATOLOGY

Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN

(2015) S. V. R. Kumar et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

T cells as a therapeutic target in SLE

(2015) D Comte et al.   LUPUS

Circulating Follicular Helper-Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity

(2015) Jin-Young Choi et al.   Arthritis & Rheumatology

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lprmice

(2014) Jason S Knight et al.   ANNALS OF THE RHEUMATIC DISEASES

Cholera Toxin B Accelerates Disease Progression in Lupus-Prone Mice by Promoting Lipid Raft Aggregation

(2014) G.-M. Deng et al.   JOURNAL OF IMMUNOLOGY

Inhibition of PI3Kδ Reduces Kidney Infiltration by Macrophages and Ameliorates Systemic Lupus in the Mouse

(2014) Abel Suárez-Fueyo et al.   JOURNAL OF IMMUNOLOGY

Increased Interleukin 21 and Follicular Helper T-like Cells and Reduced Interleukin 10+ B cells in Patients with New-onset Systemic Lupus Erythematosus

(2014) L. Wang et al.   JOURNAL OF RHEUMATOLOGY

Dose-escalation of human anti-interferon-α receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study

(2014) Avram Goldberg et al.   ARTHRITIS RESEARCH & THERAPY

Treatment of Lupus Nephritis With Abatacept: The Abatacept and Cyclophosphamide Combination Efficacy and Safety Study

(2014)   Arthritis & Rheumatology

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

(2013) Jing He et al.   IMMUNITY

Efficacy and Safety of Abatacept in Lupus Nephritis: A Twelve-Month, Randomized, Double-Blind Study

(2013) Richard Furie et al.   Arthritis & Rheumatology

Belimumab in the treatment of systemic lupus erythematosus: high disease activity predictors of response

(2012) Ronald F van Vollenhoven et al.   ANNALS OF THE RHEUMATIC DISEASES

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

BAFF/BLyS inhibitors: A new prospect for treatment of systemic lupus erythematosus

(2012) Kirsten Fairfax et al.   IUBMB LIFE

Neutrophil Extracellular Trap-Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

(2012) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Disturbed Th1, Th2, Th17 and Treg balance in patients with systemic lupus erythematosus

(2011) Sebastian Dolff et al.   CLINICAL IMMUNOLOGY

Intensive short-term treatment with rituximab, cyclophosphamide and methylprednisolone pulses induces remission in severe cases of SLE with nephritis and avoids further immunosuppressive maintenance therapy

(2011) D. Roccatello et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Abnormal activation of the Akt-GSK3β signaling pathway in peripheral blood T cells from patients with systemic lupus erythematosus

(2010) Hongfeng Tang et al.   CELL CYCLE

The imbalance between regulatory and IL-17-secreting CD4+ T cells in lupus patients

(2010) Jilin Ma et al.   CLINICAL RHEUMATOLOGY

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

Innate immunity in systemic lupus erythematosus: Sensing endogenous nucleic acids

(2010) Elena Kontaki et al.   JOURNAL OF AUTOIMMUNITY

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice

(2010) Partha S. Biswas et al.   JOURNAL OF CLINICAL INVESTIGATION

Evolution of anti- CD20 monoclonal antibody therapeutics in oncology

(2010) Ezogelin Oflazoglu et al.   mAbs

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

(2009) Ji Yang et al.   ARTHRITIS AND RHEUMATISM

The Role of IL-23/IL-17 Axis in Lupus Nephritis

(2009) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus

(2009) D. H. Kono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The innate immune system in SLE: type I interferons and dendritic cells

(2008) L Rönnblom et al.   LUPUS

Altered frequency and migration capacity of CD4+CD25+ regulatory T cells in systemic lupus erythematosus

(2008) H.-Y. Lee et al.   RHEUMATOLOGY

Regulatory T cells in systemic lupus erythematosus: past, present and future

(2008) David A Horwitz   ARTHRITIS RESEARCH & THERAPY