Systemic lupus erythematosus: still a challenge for physicians

The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies

(2016) S. Sciascia et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Sifalimumab, an anti-interferon-α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study

(2016) Munther Khamashta et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Long-Term Safety and Efficacy of Epratuzumab in the Treatment of Moderate-to- Severe Systemic Lupus Erythematosus: Results From an Open-Label Extension Study

(2016) D. J. Wallace et al.   ARTHRITIS CARE & RESEARCH

A pathogenic IFNα, BLyS and IL-17 axis in Systemic Lupus Erythematosus patients

(2016) Patricia López et al.   Scientific Reports

Treat-to-target in systemic lupus erythematosus: are we there yet?

(2016) Chi Chiu Mok   Expert Review of Clinical Pharmacology

Activated T cells enhance interferon-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes

(2015) Dag Leonard et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of subcutaneous tabalumab in patients with systemic lupus erythematosus: results from ILLUMINATE-1, a 52-week, phase III, multicentre, randomised, double-blind, placebo-controlled study

(2015) D A Isenberg et al.   ANNALS OF THE RHEUMATIC DISEASES

B cells responses and cytokine production are regulated by their immune microenvironment

(2015) Monica I. Vazquez et al.   CYTOKINE

Cytokine-producing B cells: a translational view on their roles in human and mouse autoimmune diseases

(2015) Andreia C. Lino et al.   IMMUNOLOGICAL REVIEWS

Immunogenetics of systemic lupus erythematosus: A comprehensive review

(2015) Yogita Ghodke-Puranik et al.   JOURNAL OF AUTOIMMUNITY

The Expression of BAFF Is Controlled by IRF Transcription Factors

(2015) Maria Sjöstrand et al.   JOURNAL OF IMMUNOLOGY

An epigenome-wide association study of total serum immunoglobulin E concentration

(2015) Liming Liang et al.   NATURE

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

(2015) James Bentham et al.   NATURE GENETICS

Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus

(2015) Christopher M Tipton et al.   NATURE IMMUNOLOGY

Self-reactive IgE exacerbates interferon responses associated with autoimmunity

(2015) Jill Henault et al.   NATURE IMMUNOLOGY

The Role of Cell Death in the Pathogenesis of SLE: Is Pyroptosis the Missing Link?

(2015) M. Magna et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources

(2015) Jonatan Leffler et al.   ARTHRITIS RESEARCH & THERAPY

Impact of autoimmune risk alleles on the immune system

(2015) John P Ray et al.   Genome Medicine

Functional Anti-CD94/NKG2A and Anti-CD94/NKG2C Autoantibodies in Patients With Systemic Lupus Erythematosus

(2015) Niklas Hagberg et al.   Arthritis & Rheumatology

Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptor

(2015) Eric H. Chang et al.   EBioMedicine

Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus

(2015) Sharon A. Chung et al.   PLoS One

Efficacy and safety of atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial)

(2014) David Isenberg et al.   ANNALS OF THE RHEUMATIC DISEASES

Reactive Oxygen Species Deficiency Induces Autoimmunity with Type 1 Interferon Signature

(2014) Tiina Kelkka et al.   ANTIOXIDANTS & REDOX SIGNALING

Systemic lupus erythematosus and pregnancy outcomes

(2014) Erica Peart et al.   CURRENT OPINION IN RHEUMATOLOGY

Beyond apoptosis in lupus

(2014) Lucrezia Colonna et al.   CURRENT OPINION IN RHEUMATOLOGY

Advances in lupus genetics and epigenetics

(2014) Yun Deng et al.   CURRENT OPINION IN RHEUMATOLOGY

Molecular mechanisms of congenital heart block

(2014) Aurélie Ambrosi et al.   EXPERIMENTAL CELL RESEARCH

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Environmental Influences on Systemic Lupus Erythematosus Expression

(2014) Diane L. Kamen   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Neutrophil Extracellular Trap-Derived Enzymes Oxidize High-Density Lipoprotein: An Additional Proatherogenic Mechanism in Systemic Lupus Erythematosus

(2014) Carolyne K. Smith et al.   Arthritis & Rheumatology

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Coronary Heart Disease in Systemic Lupus Erythematosus Is Associated With Interferon Regulatory Factor-8 Gene Variants

(2013) Dag Leonard et al.   Circulation-Cardiovascular Genetics

The Early Protective Effect of Hydroxychloroquine on the Risk of Cumulative Damage in Patients with Systemic Lupus Erythematosus

(2013) P. S. Akhavan et al.   JOURNAL OF RHEUMATOLOGY

Human Parvovirus B19 Induced Apoptotic Bodies Contain Altered Self-Antigens that are Phagocytosed by Antigen Presenting Cells

(2013) Kanoktip Thammasri et al.   PLoS One

Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis

(2013) Karin Bolin et al.   PLoS One

Pathogenic Mechanisms in Lupus Nephritis: Nucleosomes Bind Aberrant Laminin β1 With High Affinity and Colocalize in the Electron-Dense Deposits

(2013) Anders I. Olin et al.   Arthritis & Rheumatology

B lymphocytes enhance interferon-α production by plasmacytoid dendritic cells

(2012) Olof Berggren et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab study

(2012) Brad H. Rovin et al.   ARTHRITIS AND RHEUMATISM

Disease Mechanisms in Rheumatology-Tools and Pathways: Plasmacytoid Dendritic Cells and Their Role in Autoimmune Rheumatic Diseases

(2012) Maija-Leena Eloranta et al.   ARTHRITIS AND RHEUMATISM

The interferon signature in autoimmune diseases

(2012) Lars Rönnblom et al.   CURRENT OPINION IN RHEUMATOLOGY

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus

(2012) Karim Sacre et al.   ARTHRITIS RESEARCH & THERAPY

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

(2011) Richard Furie et al.   ARTHRITIS AND RHEUMATISM

Use of atorvastatin in systemic lupus erythematosus in children and adolescents

(2011) L. E. Schanberg et al.   ARTHRITIS AND RHEUMATISM

Drug-Induced Lupus Erythematosus

(2011) Christopher Chang et al.   DRUG SAFETY

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase

(2011) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: Results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial

(2010) J. T. Merrill et al.   ARTHRITIS AND RHEUMATISM

How does interferon-α insult the vasculature? Let me count the ways

(2010) Mariana J. Kaplan et al.   ARTHRITIS AND RHEUMATISM

Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated with vascular disease

(2010) C. Lood et al.   BLOOD

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

(2010) M. F. Denny et al.   JOURNAL OF IMMUNOLOGY

Platelet CD154 Potentiates Interferon-  Secretion by Plasmacytoid Dendritic Cells in Systemic Lupus Erythematosus

(2010) P. Duffau et al.   Science Translational Medicine

A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus

(2009) E. Svenungsson et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial

(2009) Joan T. Merrill et al.   ARTHRITIS AND RHEUMATISM

Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review

(2008) G Ruiz-Irastorza et al.   ANNALS OF THE RHEUMATIC DISEASES

Moderate alcohol drinking might be protective for systemic lupus erythematosus: a systematic review and meta-analysis

(2008) Jing Wang et al.   CLINICAL RHEUMATOLOGY

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

(2008) S. Sigurdsson et al.   HUMAN MOLECULAR GENETICS

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE