Adenosine Triphosphate Release and P2 Receptor Signaling in Piezo1 Channel-Dependent Mechanoregulation

The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration

(2019) Yuanquan Song et al.   NEURON

Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration

(2019) Zhicheng Huang et al.   BIOSCIENCE REPORTS

Physiopathological Role of the Vesicular Nucleotide Transporter (VNUT) in the Central Nervous System: Relevance of the Vesicular Nucleotide Release as a Potential Therapeutic Target

(2019) María T. Miras-Portugal et al.   Frontiers in Cellular Neuroscience

Shear stress–induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure

(2019) Andras Iring et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions

(2019) Emily E. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and mechanogating of the mammalian tactile channel PIEZO2

(2019) Li Wang et al.   NATURE

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

(2019) Angel G. Solis et al.   NATURE

Force-induced conformational changes in PIEZO1

(2019) Yi-Chih Lin et al.   NATURE

Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation

(2018) Elizabeth L Evans et al.   BRITISH JOURNAL OF PHARMACOLOGY

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection

(2018) Shang Ma et al.   CELL

Why the impact of mechanical stimuli on stem cells remains a challenge

(2018) Roman Goetzke et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ATP Release Channels

(2018) Akiyuki Taruno   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vesicular nucleotide transporter mediates ATP release and migration in neutrophils

(2018) Yuika Harada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Mechanosensitive Transient Receptor Potential/Piezo Channels in Odontoblasts Generates Action Potentials in Cocultured Isolectin B 4 –negative Medium-sized Trigeminal Ganglion Neurons

(2018) Masaki Sato et al.   JOURNAL OF ENDODONTICS

PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis

(2018) Jinglin Zhang et al.   MOLECULAR CARCINOGENESIS

Structure and mechanogating mechanism of the Piezo1 channel

(2018) Qiancheng Zhao et al.   NATURE

ATP-activated P2X7 receptor in the pathophysiology of mood disorders and as an emerging target for the development of novel antidepressant therapeutics

(2018) Linyu Wei et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mechanical stretch-induced osteogenic differentiation of human jaw bone marrow mesenchymal stem cells (hJBMMSCs) via inhibition of the NF-κB pathway

(2018) Xiaoyan Chen et al.   Cell Death & Disease

Carbenoxolone inhibits mechanical stress-induced osteogenic differentiation of mesenchymal stem cells by regulating p38 MAPK phosphorylation

(2018) Shenglong Li et al.   Experimental and Therapeutic Medicine

The Metabotropic Purinergic P2Y Receptor Family as Novel Drug Target in Epilepsy

(2018) Mariana Alves et al.   Frontiers in Pharmacology

Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells

(2018) Josefina Inés del Mármol et al.   eLife

The mechanosensitive Piezo1 channel: a three‐bladed propeller‐like structure and a lever‐like mechanogating mechanism

(2018) Qiancheng Zhao et al.   FEBS Journal

PIEZO1-R1864H rare variant accounts for a genetic phenotype-modifier role in dehydrated hereditary stomatocytosis

(2017) Immacolata Andolfo et al.   HAEMATOLOGICA

Role of Piezo Channels in Ultrasound-stimulated Dental Stem Cells

(2017) Qianhua Gao et al.   JOURNAL OF ENDODONTICS

Mechanical stretch triggers rapid epithelial cell division through Piezo1

(2017) S. A. Gudipaty et al.   NATURE

Structure of the mechanically activated ion channel Piezo1

(2017) Kei Saotome et al.   NATURE

Piezos thrive under pressure: mechanically activated ion channels in health and disease

(2017) Swetha E. Murthy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vesicular nucleotide transporter (VNUT): appearance of an actress on the stage of purinergic signaling

(2017) Yoshinori Moriyama et al.   Purinergic Signalling

How cells channel their stress: Interplay between Piezo1 and the cytoskeleton

(2017) Jamison L. Nourse et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Touch, Tension, and Transduction – The Function and Regulation of Piezo Ion Channels

(2017) Jason Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Carcinoma-specific expression of P2Y11 receptor and its contribution in ATP-induced purinergic signalling and cell migration in human hepatocellular carcinoma cells

(2017) Madiha Khalid et al.   Oncotarget

PIEZO1-R1864H rare variant accounts for a genetic phenotype-modifier role in dehydrated hereditary stomatocytosis

(2017) Immacolata Andolfo et al.   HAEMATOLOGICA

Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel

(2017) Alejandro Berna-Erro et al.   Scientific Reports

Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells

(2017) Asuna Sugimoto et al.   Scientific Reports

P2Y2 receptor modulates shear stress-induced cell alignment and actin stress fibers in human umbilical vein endothelial cells

(2016) Ramasri Sathanoori et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expression of P2 Purinergic Receptors in Mesenchymal Stem Cells and Their Roles in Extracellular Nucleotide Regulation of Cell Functions

(2016) Lin-Hua Jiang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Endothelial fluid shear stress sensing in vascular health and disease

(2016) Nicolas Baeyens et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

(2016) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Receptors, channels and signalling in the urothelial sensory system in the bladder

(2016) Liana Merrill et al.   Nature Reviews Urology

Purinergic receptors in psychiatric disorders

(2016) Ute Krügel   NEUROPHARMACOLOGY

Purinergic and Store-Operated Ca2+ Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP-Induced Stimulation of Cell Migration

(2016) Hongsen Peng et al.   STEM CELLS

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

(2016) Takahiro Masuda et al.   Nature Communications

Urothelial ATP exocytosis: regulation of bladder compliance in the urine storage phase

(2016) Hiroshi Nakagomi et al.   Scientific Reports

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways

(2016) Wei-Chien Hung et al.   Cell Reports

Piezo1 Channels Are Inherently Mechanosensitive

(2016) Ruhma Syeda et al.   Cell Reports

Functional role of mechanosensitive ion channel Piezo1 in human periodontal ligament cells

(2015) Ying Jin et al.   ANGLE ORTHODONTIST

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives

(2015) Sébastien Roger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction

(2015) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Pannexin 1 channels mediate the release of ATP into the lumen of the rat urinary bladder

(2015) Jonathan M. Beckel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Piezo1 regulates mechanotransductive release of ATP from human RBCs

(2015) Eyup Cinar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line

(2015) Chouyang Li et al.   Scientific Reports

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

Piezo1 links mechanical forces to red blood cell volume

(2015) Stuart M Cahalan et al.   eLife

Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

(2015) Amanda H Lewis et al.   eLife

Mechanosensing at the Vascular Interface

(2014) John M. Tarbell et al.   Annual Review of Biomedical Engineering

Biology of purinergic signalling: Its ancient evolutionary roots, its omnipresence and its multiple functional significance

(2014) Alexei Verkhratsky et al.   BIOESSAYS

The activation of P2Y2 receptors increases MCF-7 breast cancer cells migration through the MEK-ERK1/2 signalling pathway

(2014) Stéphanie Chadet et al.   CARCINOGENESIS

Piezo1 Is as a Novel Trefoil Factor Family 1 Binding Protein that Promotes Gastric Cancer Cell Mobility In Vitro

(2014) Xiao-Ning Yang et al.   DIGESTIVE DISEASES AND SCIENCES

Non-Synonymous Single Nucleotide Polymorphisms in the P2X Receptor Genes: Association with Diseases, Impact on Receptor Functions and Potential Use as Diagnosis Biomarkers

(2014) Emily Caseley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

(2014) Anna M. Weihs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes

(2014) Sviatoslav N. Bagriantsev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Role for Piezo1 in Stretch-evoked Ca2+Influx and ATP Release in Urothelial Cell Cultures

(2014) Tatsuya Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impairment of vesicular ATP release affects glucose metabolism and increases insulin sensitivity

(2014) Shohei Sakamoto et al.   Scientific Reports

Exocytosis of ATP From Astrocytes Modulates Phasic and Tonic Inhibition in the Neocortex

(2014) Ulyana Lalo et al.   PLOS BIOLOGY

Platelet-Derived Nucleotides Promote Tumor-Cell Transendothelial Migration and Metastasis via P2Y2 Receptor

(2013) Dagmar Schumacher et al.   CANCER CELL

Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors

(2013) Bilel Jelassi et al.   CARCINOGENESIS

Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1

(2013) C. Bae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell biological effects of mechanical stimulations generated by focused extracorporeal shock wave applications on cultured human bone marrow stromal cells

(2013) Frank Suhr et al.   Stem Cell Research

Shockwaves Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells Through ATP Release and Activation of P2X7 Receptors

(2013) Dahui Sun et al.   STEM CELLS

Low-Level Shear Stress Induces Human Mesenchymal Stem Cell Migration Through the SDF-1/CXCR4 Axis Via MAPK Signaling Pathways

(2013) Lin Yuan et al.   STEM CELLS AND DEVELOPMENT

Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels

(2013) Juliette Albuisson et al.   Nature Communications

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

Mechanical stretch inhibits adipogenesis and stimulates osteogenesis of adipose stem cells

(2012) X. Yang et al.   CELL PROLIFERATION

Vesicular Nucleotide Transporter-Mediated ATP Release Regulates Insulin Secretion

(2012) Jessica C. Geisler et al.   ENDOCRINOLOGY

Heterosynaptic long-term depression mediated by ATP released from astrocytes

(2012) Jiadong Chen et al.   GLIA

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Migration of Human Mesenchymal Stem Cells Under Low Shear Stress Mediated by Mitogen-Activated Protein Kinase Signaling

(2012) Lin Yuan et al.   STEM CELLS AND DEVELOPMENT

The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4

(2011) Chilman Bae et al.   BIOCHEMISTRY

Mechanical derivation of functional myotubes from adipose-derived stem cells

(2011) Yu Suk Choi et al.   BIOMATERIALS

P2X7 receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness

(2011) B Jelassi et al.   ONCOGENE

Multiscale approach to link red blood cell dynamics, shear viscosity, and ATP release

(2011) A. M. Forsyth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells

(2010) Yu-Ru V Shih et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Nonsynaptic Communication Through ATP Release from Volume-Activated Anion Channels in Axons

(2010) R. D. Fields et al.   Science Signaling

Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation

(2009) Tiecheng Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+Influx and ATP Release in Primary Urothelial Cell Cultures

(2009) Tsutomu Mochizuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum

(2009) B. J. McHugh et al.   JOURNAL OF CELL SCIENCE

Signaling at Purinergic P2X Receptors

(2008) Annmarie Surprenant et al.   Annual Review of Physiology

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of a vesicular nucleotide transporter

(2008) K. Sawada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of shear-induced ATP release from red blood cells

(2008) J. Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic signalling in the nervous system: an overview

(2008) Maria P. Abbracchio et al.   TRENDS IN NEUROSCIENCES