Whole Blood Based Multiparameter Assessment of Thrombus Formation in Standard Microfluidic Devices to Proxy In Vivo Haemostasis and Thrombosis

Downstream platelet adhesion and activation under highly elevated upstream shear forces

(2019) Shekh M. Rahman et al.   Acta Biomaterialia

Defective Zn2+ homeostasis in mouse and human platelets with α- and δ-storage pool diseases

(2019) Sanjeev Kiran Gotru et al.   Scientific Reports

AMPK-ACC signaling modulates platelet phospholipids content and potentiates platelet function and thrombus formation

(2018) Sophie Lepropre et al.   BLOOD

High-throughput measurement of human platelet aggregation under flow: application in hemostasis and beyond

(2018) Sanne L. N. Brouns et al.   PLATELETS

Role of CD40 and ADAMTS13 in von Willebrand factor-mediated endothelial cell–platelet–monocyte interaction

(2018) Miruna Popa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microengineered vascularized bleeding model that integrates the principal components of hemostasis

(2018) Yumiko Sakurai et al.   Nature Communications

A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding

(2018) Constance C. F. M. J. Baaten et al.   BLOOD

High-throughput elucidation of thrombus formation reveals sources of platelet function variability

(2018) Johanna P. van Geffen et al.   HAEMATOLOGICA

Platelet biology and functions: new concepts and clinical perspectives

(2018) Paola E. J. van der Meijden et al.   Nature Reviews Cardiology

Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies

(2017) Magdolna Nagy et al.   HAEMATOLOGICA

Recombinant factor VIIa addition to haemophilic blood perfused over collagen/tissue factor can sufficiently bypass the factor IXa/VIIIa defect to rescue fibrin generation

(2017) R. Li et al.   HAEMOPHILIA

Evaluation of a microfluidic flow assay to screen for von Willebrand disease and low von Willebrand factor levels

(2017) M. Lehmann et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

(2017) Pedro F. Costa et al.   LAB ON A CHIP

Flow chamber and microfluidic approaches for measuring thrombus formation in genetic bleeding disorders

(2017) Rogier M. Schoeman et al.   PLATELETS

Use of microfluidics to assess the platelet-based control of coagulation

(2017) Magdolna Nagy et al.   PLATELETS

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation

(2017) Philipp von Hundelshausen et al.   Science Translational Medicine

Platelet function is modified by common sequence variation in megakaryocyte super enhancers

(2017) Romina Petersen et al.   Nature Communications

Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies

(2017) Magdolna Nagy et al.   HAEMATOLOGICA

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

(2017) Alison Michels et al.   Jove-Journal of Visualized Experiments

Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and LeukocytesSignificance

(2016) Norbert Gerdes et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet Control of Fibrin Distribution and Microelasticity in Thrombus Formation Under FlowSignificance

(2016) Frauke Swieringa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium

(2016) Abhishek Jain et al.   BIOMEDICAL MICRODEVICES

Dynamics of Blood Flow and Thrombus Formation in a Multi-Bypass Microfluidic Ladder Network

(2016) Jevgenia Zilberman-Rudenko et al.   Cellular and Molecular Bioengineering

A Microfluidic Model of Hemostasis Sensitive to Platelet Function and Coagulation

(2016) R. M. Schoeman et al.   Cellular and Molecular Bioengineering

Minimum wound size for clotting: flowing blood coagulates on a single collagen fiber presenting tissue factor and von Willebrand factor

(2016) Shu Zhu et al.   Integrative Biology

Activation of protein C and thrombin activable fibrinolysis inhibitor on cultured human endothelial cells

(2016) C. Wu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Von Willebrand factor regulates complement on endothelial cells

(2016) Damien G. Noone et al.   KIDNEY INTERNATIONAL

Counting the platelets: a robust and sensitive quantification method for thrombus formation

(2016) Tomas Lindahl et al.   THROMBOSIS AND HAEMOSTASIS

Platelets and coagulation in thrombus formation: aberrations in the Scott syndrome

(2016) Johanna P. van Geffen et al.   THROMBOSIS RESEARCH

Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow

(2015) C. S. Whyte et al.   BLOOD

Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow

(2015) F. Swieringa et al.   HAEMATOLOGICA

A vascular injury model using focal heat-induced activation of endothelial cells

(2015) J. L. Sylman et al.   Integrative Biology

Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling

(2015) Alice Y. Pollitt et al.   THROMBOSIS AND HAEMOSTASIS

Platelets from flowing blood attach to the inflammatory chemokine CXCL16 expressed in the endothelium of the human vessel wall

(2015) Sascha Meyer dos Santos et al.   THROMBOSIS AND HAEMOSTASIS

Flow-driven assembly of VWF fibres and webs in in vitro microvessels

(2015) Ying Zheng et al.   Nature Communications

Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow

(2015) F. Swieringa et al.   HAEMATOLOGICA

Supporting Roles of Platelet Thrombospondin-1 and CD36 in Thrombus Formation on Collagen

(2014) Marijke J.E. Kuijpers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Decreased platelet aggregation by shear stress-stimulated endothelial cells in vitro: Description of a method and first results in diabetes

(2014) Maria S De Franceschi et al.   Diabetes & Vascular Disease Research

Insights into platelet-based control of coagulation

(2014) Susanne M. de Witt et al.   THROMBOSIS RESEARCH

Identification of platelet function defects by multi-parameter assessment of thrombus formation

(2014) Susanne M. de Witt et al.   Nature Communications

Microfluidics and Coagulation Biology

(2013) Thomas V. Colace et al.   Annual Review of Biomedical Engineering

Acid Sphingomyelinase Regulates Platelet Cell Membrane Scrambling, Secretion, and Thrombus Formation

(2013) Patrick Münzer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

New Fundamentals in Hemostasis

(2013) Henri H. Versteeg et al.   PHYSIOLOGICAL REVIEWS

Sources of Variability in Platelet Accumulation on Type 1 Fibrillar Collagen in Microfluidic Flow Assays

(2013) Keith B. Neeves et al.   PLoS One

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

(2013) Erik Westein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of platelet sensitivity to inhibitors of COX-1, P2Y1, and P2Y12 using a whole blood microfluidic flow assay

(2013) Ruizhi Li et al.   THROMBOSIS RESEARCH

Thrombus Growth and Embolism on Tissue Factor-Bearing Collagen Surfaces Under Flow

(2012) Thomas V. Colace et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evaluation of participants with suspected heritable platelet function disorders including recommendation and validation of a streamlined agonist panel

(2012) B. B. Dawood et al.   BLOOD

Monitoringin vitrothrombus formation with novel microfluidic devices

(2012) Erik Westein et al.   PLATELETS

Measurement of whole blood thrombus formation using parallel-plate flow chambers – a practical guide

(2012) Roger Van Kruchten et al.   PLATELETS

Defects in Glanzmann thrombasthenia and LAD-III (LAD-1/v) syndrome: the role of integrin  1 and  3 in platelet adhesion to collagen

(2011) E. van de Vijver et al.   BLOOD

Guidelines for the laboratory investigation of heritable disorders of platelet function

(2011) Paul Harrison et al.   BRITISH JOURNAL OF HAEMATOLOGY

Flow chamber-based assays to measure thrombus formation in vitro: requirements for standardization

(2011) M. ROEST et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The impact of factor Xa inhibition on axial dependent arterial thrombus formation triggered by a tissue factor rich surface

(2011) Nicholas Pugh et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Stabilizing Role of Platelet P2Y12 Receptors in Shear-Dependent Thrombus Formation on Ruptured Plaques

(2010) Reyhan Nergiz-Unal et al.   PLoS One

Dual role of collagen in factor XII-dependent thrombus formation

(2009) P. E. J. van der Meijden et al.   BLOOD

A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood

(2009) Francisco Javier Tovar-Lopez et al.   LAB ON A CHIP

Impaired thrombin generation and fibrin clot formation in patients with dilutional coagulopathy during major surgery

(2009) Saskia Schols et al.   THROMBOSIS AND HAEMOSTASIS