Crumbs organizes the transport machinery by regulating apical levels of PI(4,5)P2 in Drosophila

Comprehensive knockout analysis of the Rab family GTPases in epithelial cells

(2019) Yuta Homma et al.   JOURNAL OF CELL BIOLOGY

Cytocortex-dependent dynamics of Drosophila Crumbs controls junctional stability and tension during germ band retraction

(2019) Anna T. Bajur et al.   JOURNAL OF CELL SCIENCE

DrosophilaBig bang regulates the apical cytocortex and wing growth through junctional tension

(2018) Giorgos Tsoumpekos et al.   JOURNAL OF CELL BIOLOGY

The Phosphatase PTPL1 Is Required for PTEN-Mediated Regulation of Apical Membrane Size

(2018) Lucas J. M. Bruurs et al.   MOLECULAR AND CELLULAR BIOLOGY

A dual role of the extracellular domain of Drosophila Crumbs for morphogenesis of the embryonic neuroectoderm

(2018) Shradha Das et al.   Biology Open

Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster

(2018) Irene Miguel-Aliaga et al.   GENETICS

The phospholipid PI(3,4)P2 is an apical identity determinant

(2018) Álvaro Román-Fernández et al.   Nature Communications

Neuralized regulates Crumbs endocytosis and epithelium morphogenesis via specific Stardust isoforms

(2017) Gantas Perez-Mockus et al.   JOURNAL OF CELL BIOLOGY

Molecular mechanisms of developmentally programmed crinophagy inDrosophila

(2017) Tamás Csizmadia et al.   JOURNAL OF CELL BIOLOGY

Real-time insights into regulated exocytosis

(2017) Duy T. Tran et al.   JOURNAL OF CELL SCIENCE

Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs

(2017) Milena Pellikka et al.   JOURNAL OF CELL SCIENCE

Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy

(2017) Qiang Feng et al.   JOURNAL OF CELL SCIENCE

Transmission of cytokinesis forces via E-cadherin dilution and actomyosin flows

(2017) Diana Pinheiro et al.   NATURE

Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with microvillus inclusion disease

(2017) Georg F. Vogel et al.   TRAFFIC

Stratum, a Homolog of the Human GEF Mss4, Partnered with Rab8, Controls the Basal Restriction of Basement Membrane Proteins in Epithelial Cells

(2017) Olivier Devergne et al.   Cell Reports

The Crumbs_C isoform ofDrosophilashows tissue- and stage-specific expression and prevents light-dependent retinal degeneration

(2017) Stephanie Spannl et al.   Biology Open

Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium

(2017) Pauline Salis et al.   Scientific Reports

Dynamics of epithelial cell polarity in Drosophila: how to regulate the regulators?

(2016) David Flores-Benitez et al.   CURRENT OPINION IN CELL BIOLOGY

DrosophilaCrumbs prevents ectopic Notch activation in developing wings by inhibiting ligand-independent endocytosis

(2016) Linda Nemetschke et al.   DEVELOPMENT

Rab6 functions in polarized transport inDrosophilaphotoreceptors

(2016) Takunori Satoh et al.   FLY

Shot and Patronin polarise microtubules to direct membrane traffic and biogenesis of microvilli in epithelia

(2016) Ichha Khanal et al.   JOURNAL OF CELL SCIENCE

The zebrafish goosepimples/myosin Vb mutant exhibits cellular attributes of human microvillus inclusion disease

(2016) Jaydeep Sidhaye et al.   MECHANISMS OF DEVELOPMENT

Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation

(2016) Nitya Ramkumar et al.   NATURE CELL BIOLOGY

Complex Polarity: Building Multicellular Tissues Through Apical Membrane Traffic

(2016) Alvaro Román-Fernández et al.   TRAFFIC

Cytoskeletal Integrators: The Spectrin Superfamily

(2016) Ronald K.H. Liem   Cold Spring Harbor Perspectives in Biology

An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling

(2016) Arunachalam Vinayagam et al.   Cell Reports

Rab6 Is Required for Multiple Apical Transport Pathways but Not the Basolateral Transport Pathway in Drosophila Photoreceptors

(2016) Nozomi Iwanami et al.   PLoS Genetics

Structure, Regulation, and Functional Diversity of Microvilli on the Apical Domain of Epithelial Cells

(2015) Cécile Sauvanet et al.   Annual Review of Cell and Developmental Biology

Polarized Protein Transport and Lumen Formation During Epithelial Tissue Morphogenesis

(2015) Alex J. Blasky et al.   Annual Review of Cell and Developmental Biology

Phosphoinositide signalling in Drosophila

(2015) Sruthi S. Balakrishnan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The transmembrane protein Crumbs displays complex dynamics during follicular morphogenesis and is regulated competitively by Moesin and aPKC

(2015) K. M. Sherrard et al.   DEVELOPMENT

Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap

(2015) Aleksander D. Szymaniak et al.   DEVELOPMENTAL CELL

Endogenously Tagged Rab Proteins: A Resource to Study Membrane Trafficking in Drosophila

(2015) Sebastian Dunst et al.   DEVELOPMENTAL CELL

Structural Basis for the Phosphorylation-regulated Interaction between the Cytoplasmic Tail of Cell Polarity Protein Crumbs and the Actin-binding Protein Moesin

(2015) Zhiyi Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging roles of PtdIns(4,5)P2 - beyond the plasma membrane

(2015) X. Tan et al.   JOURNAL OF CELL SCIENCE

Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes

(2015) B. C. Knowles et al.   JOURNAL OF CELL SCIENCE

CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling

(2015) Elise Loie et al.   MOLECULAR AND CELLULAR BIOLOGY

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking

(2015) Kerstin Schneeberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization

(2015) Juan Peng et al.   Nature Communications

Arp2/3-mediated F-actin formation controls regulated exocytosis in vivo

(2015) Duy T. Tran et al.   Nature Communications

Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo

(2015) Lucie E. Charrier et al.   Scientific Reports

Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila

(2015) David Flores-Benitez et al.   eLife

Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove

(2015) Marina E. Ivanova et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Bazooka/PAR3 is dispensable for polarity in Drosophila follicular epithelial cells

(2015) J. Shahab et al.   Biology Open

PTEN

(2014) Carolyn A. Worby et al.   Annual Review of Biochemistry

PI(4,5)P2 Produced by the PI4P5K SKTL Controls Apical Size by Tethering PAR-3 in Drosophila Epithelial Cells

(2014) Sandra Claret et al.   CURRENT BIOLOGY

A fat body-derived apical extracellular matrix enzyme is transported to the tracheal lumen and is required for tube morphogenesis in Drosophila

(2014) B. Dong et al.   DEVELOPMENT

The transmembrane protein Macroglobulin complement-related is essential for septate junction formation and epithelial barrier function in Drosophila

(2014) T. Batz et al.   DEVELOPMENT

Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation

(2014) SeYeon Chung et al.   DEVELOPMENT

ERM proteins at a glance

(2014) Andrea I. McClatchey   JOURNAL OF CELL SCIENCE

Myosin VIIA regulates microvillus morphogenesis and interacts with cadherin Cad99C in Drosophila oogenesis

(2014) C. Glowinski et al.   JOURNAL OF CELL SCIENCE

Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease

(2014) Byron C. Knowles et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

Quantifying Drosophila food intake: comparative analysis of current methodology

(2014) Sonali A Deshpande et al.   NATURE METHODS

Organization and execution of the epithelial polarity programme

(2014) Enrique Rodriguez-Boulan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate

(2014) O. Devergne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Crumbs tail in complex with the PALS1 PDZ–SH3–GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex

(2014) Youjun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cargo Sorting in the Endocytic Pathway: A Key Regulator of Cell Polarity and Tissue Dynamics

(2014) S. Eaton et al.   Cold Spring Harbor Perspectives in Biology

Rab Proteins and the Compartmentalization of the Endosomal System

(2014) A. Wandinger-Ness et al.   Cold Spring Harbor Perspectives in Biology

Building and specializing epithelial tubular organs: the Drosophila salivary gland as a model system for revealing how epithelial organs are specified, form and specialize

(2014) SeYeon Chung et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The Digestive Tract ofDrosophila melanogaster

(2013) Bruno Lemaitre et al.   Annual Review of Genetics

The Protein 4.1 family: Hub proteins in animals for organizing membrane proteins

(2013) Anthony J. Baines et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Complexities of Crumbs Function and Regulation in Tissue Morphogenesis

(2013) Shirin Meher Pocha et al.   CURRENT BIOLOGY

Rab GTPase regulation of membrane identity

(2013) Suzanne R Pfeffer   CURRENT OPINION IN CELL BIOLOGY

Tubulogenesis

(2013) M. L. Iruela-Arispe et al.   DEVELOPMENT

Evidence for defective Rab GTPase-dependent cargo traffic in immune disorders

(2013) Konrad Krzewski et al.   EXPERIMENTAL CELL RESEARCH

Crumbs3 Is Essential for Proper Epithelial Development and Viability

(2013) E. L. Whiteman et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification and characterization of multiple novel Rab–myosin Va interactions

(2013) Andrew J. Lindsay et al.   MOLECULAR BIOLOGY OF THE CELL

Rab11 regulates cell–cell communication during collective cell movements

(2013) Damien Ramel et al.   NATURE CELL BIOLOGY

Crumbs Affects Protein Dynamics In Anterior Regions Of The Developing Drosophila Embryo

(2013) João Firmino et al.   PLoS One

Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control

(2013) Bo Dong et al.   Nature Communications

Apical targeting of the formin Diaphanous in Drosophila tubular epithelia

(2013) Tal Rousso et al.   eLife

Phosphoinositides and vesicular membrane traffic

(2012) Peter Mayinger   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Anisotropy of Crumbs and aPKC Drives Myosin Cable Assembly during Tube Formation

(2012) Katja Röper   DEVELOPMENTAL CELL

Obstructor-A Is Required for Epithelial Extracellular Matrix Dynamics, Exoskeleton Function, and Tubulogenesis

(2012) Georg Petkau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crumbs limits oxidase-dependent signaling to maintain epithelial integrity and prevent photoreceptor cell death

(2012) François J.-M. Chartier et al.   JOURNAL OF CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The Apical Polarity Protein Network in Drosophila Epithelial Cells: Regulation of Polarity, Junctions, Morphogenesis, Cell Growth, and Survival

(2011) Ulrich Tepass   Annual Review of Cell and Developmental Biology

The Hippo pathway and apico–basal cell polarity

(2011) Alice Genevet et al.   BIOCHEMICAL JOURNAL

Rab30 is required for the morphological integrity of the Golgi apparatus

(2011) Eoin E. Kelly et al.   BIOLOGY OF THE CELL

Retromer Controls Epithelial Cell Polarity by Trafficking the Apical Determinant Crumbs

(2011) Shirin Meher Pocha et al.   CURRENT BIOLOGY

Drosophila as a model for epithelial tube formation

(2011) Rika Maruyama et al.   DEVELOPMENTAL DYNAMICS

Deficiency in crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice

(2011) Zhijie Xiao et al.   DEVELOPMENTAL DYNAMICS

Crumbs regulates rhodopsin transport by interacting with and stabilizing myosin V

(2011) Shirin Meher Pocha et al.   JOURNAL OF CELL BIOLOGY

Increased levels of the cytoplasmic domain of Crumbs repolarise developing Drosophila photoreceptors

(2011) N. Muschalik et al.   JOURNAL OF CELL SCIENCE

Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size

(2011) Costin N. Antonescu et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphoinositides in Cell Architecture

(2011) A. Shewan et al.   Cold Spring Harbor Perspectives in Biology

Imaging Cell Shape Change in Living Drosophila Embryos

(2011) Lauren Figard et al.   Jove-Journal of Visualized Experiments

Sec24-Dependent Secretion Drives Cell-Autonomous Expansion of Tracheal Tubes in Drosophila

(2010) Dominique Förster et al.   CURRENT BIOLOGY

Crumbs is required to achieve proper organ size control during Drosophila head development

(2010) E. C. N. Richardson et al.   DEVELOPMENT

The Drosophila Claudin Kune-kune Is Required for Septate Junction Organization and Tracheal Tube Size Control

(2010) K. S. Nelson et al.   GENETICS

Loss-of-function of MYO5B is the main cause of microvillus inclusion disease: 15 novel mutations and a CaCo-2 RNAi cell model

(2010) Frank M. Ruemmele et al.   HUMAN MUTATION

Differential roles of PtdIns(4,5)P2 and phosphorylation in moesin activation during Drosophila development

(2010) F. Roch et al.   JOURNAL OF CELL SCIENCE

The cell adhesion molecule Roughest depends on  Heavy-spectrin during eye morphogenesis in Drosophila

(2010) H.-G. Lee et al.   JOURNAL OF CELL SCIENCE

Lipoprotein Particles Cross the Blood-Brain Barrier in Drosophila

(2010) M. Brankatschk et al.   JOURNAL OF NEUROSCIENCE

Rac1 modulation of the apical domain is negatively regulated by βHeavy-spectrin

(2010) Seung-Kyu Lee et al.   MECHANISMS OF DEVELOPMENT

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

(2010) C. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin-V Regulates oskar mRNA Localization in the Drosophila Oocyte

(2009) Jana Krauss et al.   CURRENT BIOLOGY

Epithelial Polarity Proteins Regulate Drosophila Tracheal Tube Size in Parallel to the Luminal Matrix Pathway

(2009) Patrick Laprise et al.   CURRENT BIOLOGY

JNK signalling influences intracellular trafficking during Drosophila morphogenesis through regulation of the novel target gene Rab30

(2009) Chloe Thomas et al.   DEVELOPMENTAL BIOLOGY

Apical Secretion in Epithelial Tubes of the Drosophila Embryo Is Directed by the Formin-Family Protein Diaphanous

(2009) R'ada Massarwa et al.   DEVELOPMENTAL CELL

A critical step for postsynaptic F-actin organization: Regulation of Baz/Par-3 localization by aPKC and PTEN

(2009) Preethi Ramachandran et al.   Developmental Neurobiology

A role for the extracellular domain of Crumbs in morphogenesis of Drosophila photoreceptor cells

(2009) Mélisande Richard et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

A Golgi-associated protein 4.1B variant is required for assimilation of proteins in the membrane

(2009) Q. Kang et al.   JOURNAL OF CELL SCIENCE

Apical trafficking in epithelial cells: signals, clusters and motors

(2009) O. A. Weisz et al.   JOURNAL OF CELL SCIENCE

The Crumbs complex: from epithelial-cell polarity to retinal degeneration

(2009) N. A. Bulgakova et al.   JOURNAL OF CELL SCIENCE

MyosinV controls PTEN function and neuronal cell size

(2009) Michiel T. van Diepen et al.   NATURE CELL BIOLOGY

Directed, efficient, and versatile modifications of the Drosophila genome by genomic engineering

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Domains Based on Ankyrin and Spectrin Associated with Cell-Cell Interactions

(2009) V. Bennett et al.   Cold Spring Harbor Perspectives in Biology

PIP5K-dependent production of PIP2 sustains microtubule organization to establish polarized transport in the Drosophila oocyte

(2008) L. Gervais et al.   DEVELOPMENT

Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin

(2008) Bilal E. Kerman et al.   DEVELOPMENTAL BIOLOGY

Electron microscopy of high pressure frozen samples: bridging the gap between cellular ultrastructure and atomic resolution

(2008) Daniel Studer et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Moesin Regulates the Trafficking of Nascent Clathrin-coated Vesicles

(2008) Jonathan Barroso-González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple domains of Stardust differentially mediate localisation of the Crumbs-Stardust complex during photoreceptor development in Drosophila

(2008) N. A. Bulgakova et al.   JOURNAL OF CELL SCIENCE

MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity

(2008) Thomas Müller et al.   NATURE GENETICS

Conversion of plasma membrane topology during epithelial tube connection requires Arf-like 3 small GTPase in Drosophila

(2007) Ken Kakihara et al.   MECHANISMS OF DEVELOPMENT