Complex Polarity: Building Multicellular Tissues Through Apical Membrane Traffic

The Mother Centriole Appendage Protein Cenexin Modulates Lumen Formation through Spindle Orientation

(2016) Hui-Fang Hung et al.   CURRENT BIOLOGY

Regulation of podocalyxin trafficking by Rab small GTPases in 2D and 3D epithelial cell cultures

(2016) Paulina S. Mrozowska et al.   JOURNAL OF CELL BIOLOGY

Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening

(2016) Kerstin Klinkert et al.   Nature Communications

The localisation of the apical Par/Cdc42 polarity module is specifically affected in microvillus inclusion disease

(2015) Grégoire Michaux et al.   BIOLOGY OF THE CELL

The Formin FMNL3 Controls Early Apical Specification in Endothelial Cells by Regulating the Polarized Trafficking of Podocalyxin

(2015) Mark Richards et al.   CURRENT BIOLOGY

The transmembrane protein Crumbs displays complex dynamics during follicular morphogenesis and is regulated competitively by Moesin and aPKC

(2015) K. M. Sherrard et al.   DEVELOPMENT

Control of E-cadherin apical localisation and morphogenesis by a SOAP-1/AP-1/clathrin pathway in C. elegans epidermal cells

(2015) G. Gillard et al.   DEVELOPMENT

The retromer complex in development and disease

(2015) S. Wang et al.   DEVELOPMENT

Structural Basis for the Phosphorylation-regulated Interaction between the Cytoplasmic Tail of Cell Polarity Protein Crumbs and the Actin-binding Protein Moesin

(2015) Zhiyi Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3

(2015) Georg F. Vogel et al.   JOURNAL OF CELL BIOLOGY

AP-2-complex-mediated endocytosis of Drosophila Crumbs regulates polarity by antagonizing Stardust

(2015) Y.-H. Lin et al.   JOURNAL OF CELL SCIENCE

Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs

(2015) Alejo E. Rodríguez-Fraticelli et al.   NATURE CELL BIOLOGY

A Conserved Di-Basic Motif ofDrosophilaCrumbs Contributes to Efficient ER Export

(2015) Alexandra Kumichel et al.   TRAFFIC

Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC

(2015) Salah Elias et al.   PLOS BIOLOGY

Rac1 controls epithelial tube length through the apical secretion and polarity pathways

(2015) Kévin Sollier et al.   Biology Open

Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells

(2015) Kenichiro Taniguchi et al.   Stem Cell Reports

Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation

(2014) Ivan Bedzhov et al.   CELL

Seamless Tube Shape Is Constrained by Endocytosis-Dependent Regulation of Active Moesin

(2014) Jodi Schottenfeld-Roames et al.   CURRENT BIOLOGY

The Scribble module regulates retromer-dependent endocytic trafficking during epithelial polarization

(2014) Geert de Vreede et al.   DEVELOPMENT

Rab11 Endosomes Contribute to Mitotic Spindle Organization and Orientation

(2014) Heidi Hehnly et al.   DEVELOPMENTAL CELL

A Molecular Switch for the Orientation of Epithelial Cell Polarization

(2014) David M. Bryant et al.   DEVELOPMENTAL CELL

FIP5 phosphorylation during mitosis regulates apical trafficking and lumenogenesis

(2014) D. Li et al.   EMBO REPORTS

Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease

(2014) Caroline L. Wiegerinck et al.   GASTROENTEROLOGY

The cell biology of planar cell polarity

(2014) Danelle Devenport   JOURNAL OF CELL BIOLOGY

A bidirectional antagonism between aPKC and Yurt regulates epithelial cell polarity

(2014) Clémence L. Gamblin et al.   JOURNAL OF CELL BIOLOGY

Myosin Vb and Rab11a regulate phosphorylation of ezrin in enterocytes

(2014) H. S. Dhekne et al.   JOURNAL OF CELL SCIENCE

Organization and execution of the epithelial polarity programme

(2014) Enrique Rodriguez-Boulan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Four-dimensional live imaging of apical biosynthetic trafficking reveals a post-Golgi sorting role of apical endosomal intermediates

(2014) R. Thuenauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular organization and function of invertebrate occluding junctions

(2014) Yasushi Izumi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cargo Sorting in the Endocytic Pathway: A Key Regulator of Cell Polarity and Tissue Dynamics

(2014) S. Eaton et al.   Cold Spring Harbor Perspectives in Biology

The Retromer Complex Is Required for Rhodopsin Recycling and Its Loss Leads to Photoreceptor Degeneration

(2014) Shiuan Wang et al.   PLOS BIOLOGY

Rab11a is required for apical protein localisation in the intestine

(2014) T. Sobajima et al.   Biology Open

lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK

(2014) Linda Parsons et al.   Cancers

A Rab10-Dependent Mechanism for Polarized Basement Membrane Secretion during Organ Morphogenesis

(2013) David W. Lerner et al.   DEVELOPMENTAL CELL

Cdc42 Coordinates Proliferation, Polarity, Migration, and Differentiation of Small Intestinal Epithelial Cells in Mice

(2013) Jaime Melendez et al.   GASTROENTEROLOGY

Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation

(2013) Ceniz Zihni et al.   JOURNAL OF CELL BIOLOGY

Spatial regulation of VEGF receptor endocytosis in angiogenesis

(2013) Masanori Nakayama et al.   NATURE CELL BIOLOGY

Persistent defective membrane trafficking in epithelial cells of patients with familial hemophagocytic lymphohistiocytosis type 5 due toSTXBP2/MUNC18-2mutations

(2013) Polina Stepensky et al.   PEDIATRIC BLOOD & CANCER

Kif3a Guides Microtubular Dynamics, Migration and Lumen Formation of MDCK Cells

(2013) Christopher Boehlke et al.   PLoS One

Rhodopsin homeostasis and retinal degeneration: lessons from the fly

(2013) Bo Xiong et al.   TRENDS IN NEUROSCIENCES

Fosmid-Based Structure-Function Analysis Reveals Functionally Distinct Domains in the Cytoplasmic Domain of Drosophila Crumbs

(2013) Sven Klose et al.   G3-Genes Genomes Genetics

The Centrosome Regulates the Rab11- Dependent Recycling Endosome Pathway at Appendages of the Mother Centriole

(2012) Heidi Hehnly et al.   CURRENT BIOLOGY

A Role for the Centrosome and PAR-3 in the Hand-Off of MTOC Function during Epithelial Polarization

(2012) Jessica L. Feldman et al.   CURRENT BIOLOGY

Positive Feedback and Mutual Antagonism Combine to Polarize Crumbs in the Drosophila Follicle Cell Epithelium

(2012) Georgina C. Fletcher et al.   CURRENT BIOLOGY

Clathrin and AP-1 regulate apical polarity and lumen formation during C. elegans tubulogenesis

(2012) H. Zhang et al.   DEVELOPMENT

AP-1 is required for the maintenance of apico-basal polarity in the C. elegans intestine

(2012) M. Shafaq-Zadah et al.   DEVELOPMENT

Crb Apical Polarity Proteins Maintain Zebrafish Retinal Cone Mosaics via Intercellular Binding of Their Extracellular Domains

(2012) Jian Zou et al.   DEVELOPMENTAL CELL

Partitioning-defective Protein 6 (Par-6) Activates Atypical Protein Kinase C (aPKC) by Pseudosubstrate Displacement

(2012) Chiharu Graybill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell confinement controls centrosome positioning and lumen initiation during epithelial morphogenesis

(2012) Alejo E. Rodríguez-Fraticelli et al.   JOURNAL OF CELL BIOLOGY

Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migration

(2012) P. D. Allaire et al.   JOURNAL OF CELL SCIENCE

Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

(2012) Ryotaro Sakamori et al.   JOURNAL OF CLINICAL INVESTIGATION

Arp2/3 mediates early endosome dynamics necessary for the maintenance of PAR asymmetry in Caenorhabditis elegans

(2012) Jessica M. Shivas et al.   MOLECULAR BIOLOGY OF THE CELL

Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells

(2012) Manuel Gálvez-Santisteban et al.   NATURE CELL BIOLOGY

Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity

(2012) Julia Franziska Winter et al.   NATURE CELL BIOLOGY

RAB-5 Controls the Cortical Organization and Dynamics of PAR Proteins to Maintain C. elegans Early Embryonic Polarity

(2012) Vincent Hyenne et al.   PLoS One

Crag Is a GEF for Rab11 Required for Rhodopsin Trafficking and Maintenance of Adult Photoreceptor Cells

(2012) Bo Xiong et al.   PLOS BIOLOGY

The Apical Polarity Protein Network in Drosophila Epithelial Cells: Regulation of Polarity, Junctions, Morphogenesis, Cell Growth, and Survival

(2011) Ulrich Tepass   Annual Review of Cell and Developmental Biology

Retromer Controls Epithelial Cell Polarity by Trafficking the Apical Determinant Crumbs

(2011) Shirin Meher Pocha et al.   CURRENT BIOLOGY

Ezrin, Radixin and Moesin: key regulators of membrane–cortex interactions and signaling

(2011) Amanda L Neisch et al.   CURRENT OPINION IN CELL BIOLOGY

Retromer regulates apical–basal polarity through recycling crumbs

(2011) Bo Zhou et al.   DEVELOPMENTAL BIOLOGY

Crumbs regulates rhodopsin transport by interacting with and stabilizing myosin V

(2011) Shirin Meher Pocha et al.   JOURNAL OF CELL BIOLOGY

Interaction between FIP5 and SNX18 regulates epithelial lumen formation

(2011) Carly Willenborg et al.   JOURNAL OF CELL BIOLOGY

Dynamin- and Rab5-dependent endocytosis is required to prevent Drosophila photoreceptor degeneration

(2011) N. Pinal et al.   JOURNAL OF CELL SCIENCE

Yeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis

(2011) Guendalina Rossi et al.   MOLECULAR BIOLOGY OF THE CELL

Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization

(2011) J. T. Roland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositides in Cell Architecture

(2011) A. Shewan et al.   Cold Spring Harbor Perspectives in Biology

aPKC Phosphorylation of Bazooka Defines the Apical/Lateral Border in Drosophila Epithelial Cells

(2010) Eurico Morais-de-Sá et al.   CELL

Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded

(2010) Brian S. Robinson et al.   CURRENT BIOLOGY

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Formation of a Bazooka–Stardust complex is essential for plasma membrane polarity in epithelia

(2010) Michael P. Krahn et al.   JOURNAL OF CELL BIOLOGY

A molecular network for de novo generation of the apical surface and lumen

(2010) David M. Bryant et al.   NATURE CELL BIOLOGY

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

(2010) C. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

(2010) C.-L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamin Participates in the Maintenance of Anterior Polarity in the Caenorhabditis elegans Embryo

(2009) Yuji Nakayama et al.   DEVELOPMENTAL CELL

Independent cadherin–catenin and Bazooka clusters interact to assemble adherens junctions

(2009) Melanie A. McGill et al.   JOURNAL OF CELL BIOLOGY

Crumbs stabilises epithelial polarity during tissue remodelling

(2009) K. Campbell et al.   JOURNAL OF CELL SCIENCE

Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants

(2009) T. Vaccari et al.   JOURNAL OF CELL SCIENCE

The Crumbs complex: from epithelial-cell polarity to retinal degeneration

(2009) N. A. Bulgakova et al.   JOURNAL OF CELL SCIENCE

Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus

(2009) Daniel del Toro et al.   MOLECULAR BIOLOGY OF THE CELL

Trafficking of Crumbs3 during Cytokinesis Is Crucial for Lumen Formation

(2009) Marc A. Schlüter et al.   MOLECULAR BIOLOGY OF THE CELL

Rab11 Helps Maintain Apical Crumbs and Adherens Junctions in the Drosophila Embryonic Ectoderm

(2009) Jeremiah F. Roeth et al.   PLoS One

aPKC restricts the basolateral determinant PtdIns(3,4,5)P3 to the basal region

(2008) Shoukichi Takahama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cdc42, Par6, and aPKC Regulate Arp2/3-Mediated Endocytosis to Control Local Adherens Junction Stability

(2008) Marios Georgiou et al.   CURRENT BIOLOGY

Drosophila Cip4 and WASp Define a Branch of the Cdc42-Par6-aPKC Pathway Regulating E-Cadherin Endocytosis

(2008) Andrea Leibfried et al.   CURRENT BIOLOGY

Crag Regulates Epithelial Architecture and Polarized Deposition of Basement Membrane Proteins in Drosophila

(2008) Natalie Denef et al.   DEVELOPMENTAL CELL

Rho-Kinase Phosphorylates PAR-3 and Disrupts PAR Complex Formation

(2008) Masanori Nakayama et al.   DEVELOPMENTAL CELL

Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth

(2008) Tomoyuki Yamanaka   Frontiers in Bioscience-Landmark

Cdc42 and Par proteins stabilize dynamic adherens junctions in theDrosophilaneuroectoderm through regulation of apical endocytosis

(2008) Kathryn P. Harris et al.   JOURNAL OF CELL BIOLOGY

ROCK-mediated contractility, tight junctions and channels contribute to the conversion of a preapical patch into apical surface during isochoric lumen initiation

(2008) A. Ferrari et al.   JOURNAL OF CELL SCIENCE

Tight junctions at a glance

(2008) M. S. Balda et al.   JOURNAL OF CELL SCIENCE

Regulation of Early Endosomal Entry by the Drosophila Tumor Suppressors Rabenosyn and Vps45

(2008) Holly A. Morrison et al.   MOLECULAR BIOLOGY OF THE CELL

On the spontaneous emergence of cell polarity

(2008) Steven J. Altschuler et al.   NATURE

MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity

(2008) Thomas Müller et al.   NATURE GENETICS

From cells to organs: building polarized tissue

(2008) David M. Bryant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polarity complex proteins

(2007) Emeline Assémat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Transmembrane proteins of tight junctions

(2007) Hideki Chiba et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES