The new (dis)order in RNA regulation

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins

(2015) Eileen Chen et al.   BIOCHIMIE

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

KH–RNA interactions: back in the groove

(2015) Giuseppe Nicastro et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Relating sequence encoded information to form and function of intrinsically disordered proteins

(2015) Rahul K Das et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Position-specific binding of FUS to nascent RNA regulates mRNA length

(2015) Akio Masuda et al.   GENES & DEVELOPMENT

Intra-domain Cross-talk Regulates Serine-arginine Protein Kinase 1-dependent Phosphorylation and Splicing Function of Transformer 2β1

(2015) Michael A. Jamros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The human RBPome: From genes and proteins to human disease

(2015) Yaseswini Neelamraju et al.   Journal of Proteomics

RNA Controls PolyQ Protein Phase Transitions

(2015) Huaiying Zhang et al.   MOLECULAR CELL

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes

(2015) Irina Anosova et al.   NUCLEIC ACIDS RESEARCH

Luzp4 defines a new mRNA export pathway in cancer cells

(2015) Nicolas Viphakone et al.   NUCLEIC ACIDS RESEARCH

The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication

(2015) Chringma Sherpa et al.   NUCLEIC ACIDS RESEARCH

Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP

(2015) Nikita Vasilyev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease-associated mutation inSRSF2misregulates splicing by altering RNA-binding affinities

(2015) Jian Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The extended AT-hook is a novel RNA binding motif

(2015) Michael Filarsky et al.   RNA Biology

HIV Rev Assembly on the Rev Response Element (RRE): A Structural Perspective

(2015) Jason Rausch et al.   Viruses-Basel

The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs

(2015) Benedikt M. Beckmann et al.   Nature Communications

Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity

(2015) Peisu Zhang et al.   Nature Communications

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

(2015) Palaniraja Thandapani et al.   eLife

Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

(2015) Sonja Kroschwald et al.   eLife

FMRP interacts with G-quadruplex structures in the 3’-UTR of its dendritic target Shank1 mRNA

(2015) Yang Zhang et al.   RNA Biology

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly

(2014) Nicolas Preitner et al.   CELL

Short Linear Motifs: Ubiquitous and Functionally Diverse Protein Interaction Modules Directing Cell Regulation

(2014) Kim Van Roey et al.   CHEMICAL REVIEWS

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases

(2014) Vladimir N. Uversky et al.   CHEMICAL REVIEWS

TheRBMXgene as a candidate for the Shashi X-linked intellectual disability syndrome

(2014) V. Shashi et al.   CLINICAL GENETICS

Intrinsically disordered proteins as crucial constituents of cellular aqueous two phase systems and coacervates

(2014) Vladimir N. Uversky et al.   FEBS LETTERS

CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53

(2014) R. Saldana-Meyer et al.   GENES & DEVELOPMENT

Novel RNA-binding Protein P311 Binds Eukaryotic Translation Initiation Factor 3 Subunit b (eIF3b) to Promote Translation of Transforming Growth Factor β1-3 (TGF-β1-3)

(2014) Michael M. Yue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA Granule Assembly and Disassembly Modulated by Nuclear Factor Associated with Double-stranded RNA 2 and Nuclear Factor 45

(2014) Nobuyuki Shiina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Principles and Properties of Eukaryotic mRNPs

(2014) Sarah F. Mitchell et al.   MOLECULAR CELL

A Million Peptide Motifs for the Molecular Biologist

(2014) Peter Tompa et al.   MOLECULAR CELL

BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence

(2014) Lei Gu et al.   NATURE GENETICS

A census of human RNA-binding proteins

(2014) Stefanie Gerstberger et al.   NATURE REVIEWS GENETICS

Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation

(2014) Javier Fernandez-Chamorro et al.   NUCLEIC ACIDS RESEARCH

RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation

(2014) Muhammad Zoabi et al.   NUCLEIC ACIDS RESEARCH

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

The cooperative function of arginine residues in the Prototype Foamy Virus Gag C-terminus mediates viral and cellular RNA encapsidation

(2014) Martin V Hamann et al.   Retrovirology

mRNP granules

(2014) J Ross Buchan   RNA Biology

A versatile assay for RNA-binding proteins in living cells

(2014) C. Strein et al.   RNA

Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells

(2014) I. Kwon et al.   SCIENCE

Life of psi: How full-length HIV-1 RNAs become packaged genomes in the viral particles

(2014) Malika Kuzembayeva et al.   VIROLOGY

Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit

(2014) Pavan Kumar Puvvula et al.   Nature Communications

Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF

(2014) Richard B. Tunnicliffe et al.   PLoS Pathogens

The RNAissance family: SR proteins as multifaceted regulators of gene expression

(2014) Jonathan M. Howard et al.   Wiley Interdisciplinary Reviews-RNA

Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes

(2014) Roberto Bonasio et al.   eLife

RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev–Rev response element complex

(2014) Bhargavi Jayaraman et al.   eLife

Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts

(2014) Rasha Kanhoush et al.   Nucleus

Effect of different arginine methylations on the thermodynamics of Tat peptide binding to HIV-1 TAR RNA

(2013) Santosh Kumar et al.   BIOCHIMIE

The Arginine-Rich RNA-Binding Motif of HIV-1 Rev Is Intrinsically Disordered and Folds upon RRE Binding

(2013) Fabio Casu et al.   BIOPHYSICAL JOURNAL

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

Protein Aggregation Behavior Regulates Cyclin Transcript Localization and Cell-Cycle Control

(2013) ChangHwan Lee et al.   DEVELOPMENTAL CELL

The Nucleic Acid-binding Domain and Translational Repression Activity of aXenopusTerminal Uridylyl Transferase

(2013) Christopher P. Lapointe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Binding of Modified RGG Domain in TLS/FUS to G-Quadruplex RNA: Tyrosines in RGG Domain Recognize 2′-OH of the Riboses of Loops in G-Quadruplex

(2013) Kentaro Takahama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Defining the RGG/RG Motif

(2013) Palaniraja Thandapani et al.   MOLECULAR CELL

Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins

(2013) Yazan M. Abbas et al.   NATURE

How cells get the message: dynamic assembly and function of mRNA–protein complexes

(2013) Michaela Müller-McNicoll et al.   NATURE REVIEWS GENETICS

The RNA-binding protein repertoire of embryonic stem cells

(2013) S Chul Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NKAP is a novel RS-related protein that interacts with RNA and RNA binding proteins

(2013) B. D. Burgute et al.   NUCLEIC ACIDS RESEARCH

HMGA1 directly interacts with TAR to modulate basal and Tat-dependent HIV transcription

(2013) Sebastian Eilebrecht et al.   RNA Biology

FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns

(2013) T. Nakaya et al.   RNA

Phosphorylation Drives a Dynamic Switch in Serine/Arginine-Rich Proteins

(2013) ShengQi Xiang et al.   STRUCTURE

RNA-binding proteins in Mendelian disease

(2013) Alfredo Castello et al.   TRENDS IN GENETICS

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

(2012) Oliver D. King et al.   BRAIN RESEARCH

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Getting RNA and Protein in Phase

(2012) Stephanie C. Weber et al.   CELL

Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies

(2012) Tina W. Han et al.   CELL

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

Fragile X Syndrome

(2012) Yingratana McLennan et al.   CURRENT GENOMICS

Motif switches: decision-making in cell regulation

(2012) Kim Van Roey et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks

(2012) Marija Buljan et al.   MOLECULAR CELL

Nuclear Matrix Factor hnRNP U/SAF-A Exerts a Global Control of Alternative Splicing by Regulating U2 snRNP Maturation

(2012) Rui Xiao et al.   MOLECULAR CELL

The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

(2012) Alexander G. Baltz et al.   MOLECULAR CELL

FMRP targets distinct mRNA sequence elements to regulate protein expression

(2012) Manuel Ascano et al.   NATURE

Drosophila patterning is established by differential association of mRNAs with P bodies

(2012) Timothy T. Weil et al.   NATURE CELL BIOLOGY

A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response

(2012) Britt Adamson et al.   NATURE CELL BIOLOGY

Linear motifs confer functional diversity onto splice variants

(2012) Robert J. Weatheritt et al.   NUCLEIC ACIDS RESEARCH

TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export

(2012) Nicolas Viphakone et al.   Nature Communications

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

The Control of HIV Transcription: Keeping RNA Polymerase II on Track

(2011) Melanie Ott et al.   Cell Host & Microbe

Beyond Stereospecificity: Liquids and Mesoscale Organization of Cytoplasm

(2011) Anthony A. Hyman et al.   DEVELOPMENTAL CELL

Asyn-anticonformational difference allows SRSF2 to recognize guanines and cytosines equally well

(2011) Gerrit M Daubner et al.   EMBO JOURNAL

Identification of Ewing’s sarcoma protein as a G-quadruplex DNA- and RNA-binding protein

(2011) Kentaro Takahama et al.   FEBS Journal

The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex

(2011) C. J. David et al.   GENES & DEVELOPMENT

Corepressor Protein CDYL Functions as a Molecular Bridge between Polycomb Repressor Complex 2 and Repressive Chromatin Mark Trimethylated Histone Lysine 27

(2011) Yu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new regulatory function of the region proximal to the RGG box in the Fragile X mental retardation protein

(2011) E. Blackwell et al.   JOURNAL OF CELL SCIENCE

Cytoplasmic mRNP granules at a glance

(2011) S. L. Erickson et al.   JOURNAL OF CELL SCIENCE

Roles of intrinsic disorder in protein–nucleic acid interactions

(2011) H. Jane Dyson   Molecular BioSystems

Intrinsically disordered regions as affinity tuners in protein–DNA interactions

(2011) Dana Vuzman et al.   Molecular BioSystems

Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-β1

(2011) Antoine Cléry et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction

(2011) Anh Tuân Phan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nontelomeric splice variant of telomere repeat-binding factor 2 maintains neuronal traits by sequestering repressor element 1-silencing transcription factor

(2011) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAPD5, a noncanonical poly(A) polymerase with an unusual RNA-binding motif

(2011) C. Rammelt et al.   RNA

Dynamic protein–DNA recognition: beyond what can be seen

(2011) Monika Fuxreiter et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Matrix Protein hnRNP U Is Required for Chromosomal Localization of Xist RNA

(2010) Yuko Hasegawa et al.   DEVELOPMENTAL CELL

Polyadenylation and degradation of incomplete RNA polymerase I transcripts in mammalian cells

(2010) Natalia Shcherbik et al.   EMBO REPORTS

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA

(2010) S. Kaneko et al.   GENES & DEVELOPMENT

Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA

(2010) E. Blackwell et al.   HUMAN MOLECULAR GENETICS

Identification of a self-association domain in the Ewing's sarcoma protein: a novel function for arginine-glycine-glycine rich motifs?

(2010) D. J. Shaw et al.   JOURNAL OF BIOCHEMISTRY

Three Arginine Residues within the RGG Box Are Crucial for ICP27 Binding to Herpes Simplex Virus 1 GC-Rich Sequences and for Efficient Viral RNA Export

(2010) K. A. Corbin-Lickfett et al.   JOURNAL OF VIROLOGY

Novel Functions of Prototype Foamy Virus Gag Glycine- Arginine-Rich Boxes in Reverse Transcription and Particle Morphogenesis

(2010) E. Mullers et al.   JOURNAL OF VIROLOGY

7SK small nuclear RNA directly affects HMGA1 function in transcription regulation

(2010) S. Eilebrecht et al.   NUCLEIC ACIDS RESEARCH

Structural basis for the dual RNA-recognition modes of human Tra2-β RRM

(2010) Kengo Tsuda et al.   NUCLEIC ACIDS RESEARCH

Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1

(2010) Ming-Lung Hung et al.   NUCLEIC ACIDS RESEARCH

Proteome-Wide Search Reveals Unexpected RNA-Binding Proteins in Saccharomyces cerevisiae

(2010) Nikoleta G. Tsvetanova et al.   PLoS One

A Screen for RNA-Binding Proteins in Yeast Indicates Dual Functions for Many Enzymes

(2010) Tanja Scherrer et al.   PLoS One

Capillarity theory for the fly-casting mechanism

(2010) E. Trizac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA search efficiency is modulated by charge composition and distribution in the intrinsically disordered tail

(2010) D. Vuzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

NKAP Is a Transcriptional Repressor of Notch Signaling and Is Required for T Cell Development

(2009) Anthony G. Pajerowski et al.   IMMUNITY

Arginine Methylation of the ICP27 RGG Box Regulates ICP27 Export and Is Required for Efficient Herpes Simplex Virus 1 Replication

(2009) S. K. Souki et al.   JOURNAL OF VIROLOGY

Arginine Methylation Regulates Telomere Length and Stability

(2009) T. R. H. Mitchell et al.   MOLECULAR AND CELLULAR BIOLOGY

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

SR Proteins in Vertical Integration of Gene Expression from Transcription to RNA Processing to Translation

(2009) Xiang-Yang Zhong et al.   MOLECULAR CELL

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

The State of Synapses in Fragile X Syndrome

(2009) Brad E. Pfeiffer et al.   NEUROSCIENTIST

Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex

(2009) I. D'Orso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SR protein family

(2009) Peter J Shepard et al.   GENOME BIOLOGY

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition

The SR protein family of splicing factors: master regulators of gene expression

(2008) Jennifer C. Long et al.   BIOCHEMICAL JOURNAL

Effects of Asymmetric Arginine Dimethylation on RNA-Binding Peptides

(2008) Soonsil Hyun et al.   CHEMBIOCHEM

Expression cloning inXenopusidentifies RNA‐binding proteins as regulators of embryogenesis and Rbmx as necessary for neural and muscle development

(2008) Darwin S. Dichmann et al.   DEVELOPMENTAL DYNAMICS

A role for Q/N-rich aggregation-prone regions in P-body localization

(2008) M. A. M. Reijns et al.   JOURNAL OF CELL SCIENCE

Intrinsic Structural Disorder of DF31, aDrosophilaProtein of Chromatin Decondensation and Remodeling Activities

(2008) Edit Szőllősi et al.   JOURNAL OF PROTEOME RESEARCH

Multiple Nucleic Acid Binding Sites and Intrinsic Disorder of Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein: Implications for Ribonucleocapsid Protein Packaging

(2008) C.-K. Chang et al.   JOURNAL OF VIROLOGY

Fragile X mental retardation protein recognition of G quadruplex structure per se is sufficient for high affinity binding to RNA

(2008) Medhavi Bole et al.   Molecular BioSystems

A Solution to Limited Genomic Capacity: Using Adaptable Binding Surfaces to Assemble the Functional HIV Rev Oligomer on RNA

(2008) Matthew D. Daugherty et al.   MOLECULAR CELL

The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer

(2008) Marie-Cécile Didiot et al.   NUCLEIC ACIDS RESEARCH

Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP

(2008) Guillaume M. Hautbergue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fragile X mental retardation protein interactions with the microtubule associated protein 1B RNA

(2008) L. Menon et al.   RNA

Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome

(2008) J. Zhao et al.   SCIENCE

RNA-binding proteins in human genetic disease

(2008) Kiven E. Lukong et al.   TRENDS IN GENETICS

Diverse RNA-Binding Proteins Interact with Functionally Related Sets of RNAs, Suggesting an Extensive Regulatory System

(2008) Daniel J Hogan et al.   PLOS BIOLOGY