USP18 is a significant driver of memory CD4 T-cell reduced viability caused by type I IFN signaling during primary HIV-1 infection

Expression of PD-1 and Tim-3 markers of T-cell exhaustion is associated with CD4 dynamics during the course of untreated and treated HIV infection

(2018) Norma Rallón et al.   PLoS One

USP18 - a multifunctional component in the Interferon response

(2018) Anja Basters et al.   BIOSCIENCE REPORTS

Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction

(2018) Souheil-Antoine Younes et al.   JOURNAL OF CLINICAL INVESTIGATION

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

(2017) Kei-ichiro Arimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Type I Interferon in Chronic Virus Infection and Cancer

(2017) Laura M. Snell et al.   TRENDS IN IMMUNOLOGY

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

(2017) Kei-ichiro Arimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway

(2017) Baihai Jiao et al.   Oncotarget

Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?

(2017) Andrew L. Mellor et al.   Frontiers in Immunology

Dissecting How CD4 T Cells Are Lost During HIV Infection

(2016) Gilad Doitsh et al.   Cell Host & Microbe

Current topics in HIV pathogenesis, part 2: Inflammation drives a Warburg-like effect on the metabolism of HIV-infected subjects

(2016) Mouna Aounallah et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Too much of a good thing: Sustained type 1 interferon signaling limits humoral responses to secondary viral infection

(2016) John R. Teijaro   EUROPEAN JOURNAL OF IMMUNOLOGY

ISG15 expression correlates with HIV-1 viral load and with factors regulating T cell response

(2016) Carolina Scagnolari et al.   IMMUNOBIOLOGY

Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs

(2016) Liang Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting type I interferon–mediated activation restores immune function in chronic HIV infection

(2016) Anjie Zhen et al.   JOURNAL OF CLINICAL INVESTIGATION

Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection

(2016) Xavier Dagenais-Lussier et al.   JOURNAL OF VIROLOGY

Multiple functions of USP18

(2016) Nadine Honke et al.   Cell Death & Disease

The ISG15-specific protease USP18 regulates stability of PTEN

(2016) Lisa Maria Mustachio et al.   Oncotarget

Type I interferons in viral control and immune regulation

(2016) John R Teijaro   Current Opinion in Virology

Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection

(2016) Matthieu Daugan et al.   Frontiers in Immunology

Current topics in HIV-1 pathogenesis: The emergence of deregulated immuno-metabolism in HIV-infected subjects

(2015) Xavier Dagenais-Lussier et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Type I IFN – A blunt spear in fighting HIV-1 infection

(2015) Chiara Acchioni et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN-I responses

(2015) Nadine Honke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection

(2015) Mohammad-Ali Jenabian et al.   JOURNAL OF INFECTIOUS DISEASES

Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling

(2015) Thao P. Nguyen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IFN-α Exerts Opposing Effects on Activation-Induced and IL-7–Induced Proliferation of T Cells That May Impair Homeostatic Maintenance of CD4+T Cell Numbers in Treated HIV Infection

(2014) Lilian Cha et al.   JOURNAL OF IMMUNOLOGY

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection

(2014) I. Osokine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HTLV-1 Tax-Mediated Inhibition of FOXO3a Activity Is Critical for the Persistence of Terminally Differentiated CD4+ T Cells

(2014) David Olagnier et al.   PLoS Pathogens

Interfering with type I Interferon: A novel approach to purge persistent viral infection

(2013) Elizabeth Wilson et al.   CELL CYCLE

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Interferon-α Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers

(2013) Gareth A. D. Hardy et al.   PLoS One

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

Decoding the complexity of type I interferon to treat persistent viral infections

(2013) Elizabeth B. Wilson et al.   TRENDS IN MICROBIOLOGY

Type I Interferon Upregulates Bak and Contributes to T Cell Loss during Human Immunodeficiency Virus (HIV) Infection

(2013) Joseph A. Fraietta et al.   PLoS Pathogens

HIV-Associated Immune Activation: From Bench to Bedside

(2011) Gabriella d'Ettorre et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis

(2011) Julien van Grevenynghe et al.   JOURNAL OF CLINICAL INVESTIGATION

CD4+ T-Cell Deficiency in HIV Patients Responding to Antiretroviral Therapy Is Associated With Increased Expression of Interferon-Stimulated Genes in CD4+ T Cells

(2011) Sonia Fernandez et al.   JOURNAL OF INFECTIOUS DISEASES

Immunologic Failure Despite Suppressive Antiretroviral Therapy Is Related to Activation and Turnover of Memory CD4 Cells

(2011) Michael M. Lederman et al.   JOURNAL OF INFECTIOUS DISEASES

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4+ T-cell counts during antiretroviral therapy

(2010) Stefania Piconi et al.   AIDS

Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV

(2010) Nicolas Chomont et al.   Current Opinion in HIV and AIDS

Modulation of indoleamine-2,3-dioxygenase expression and activity by HIV-1 in human macrophages

(2009) Benjamin Manéglier et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Poor Initial CD4+ Recovery With Antiretroviral Therapy Prolongs Immune Depletion and Increases Risk for AIDS and Non-AIDS Diseases

(2009) Jason V Baker et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Increased Interferon Alpha Expression in Circulating Plasmacytoid Dendritic Cells of HIV-1-Infected Patients

(2009) Clara Lehmann et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Phenotypic classification of human CD4+ T cell subsets and their differentiation

(2008) R. Okada et al.   INTERNATIONAL IMMUNOLOGY

Transcription factor FOXO3a controls the persistence of memory CD4+ T cells during HIV infection

(2008) Julien van Grevenynghe et al.   NATURE MEDICINE

HIV-Induced Type I Interferon and Tryptophan Catabolism Drive T Cell Dysfunction Despite Phenotypic Activation

(2008) Adriano Boasso et al.   PLoS One

Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection

(2008) Julien van Grevenynghe et al.   SEMINARS IN IMMUNOLOGY

HIV-1 induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo

(2007) A. Biancotto et al.   BLOOD

Chronic innate immune activation as a cause of HIV-1 immunopathogenesis

(2007) Adriano Boasso et al.   CLINICAL IMMUNOLOGY