Therapeutic Efficacy of Palmitoylethanolamide and Its New Formulations in Synergy with Different Antioxidant Molecules Present in Diets

N-Palmitoylethanolamine-oxazoline (PEA-OXA): A new therapeutic strategy to reduce neuroinflammation, oxidative stress associated to vascular dementia in an experimental model of repeated bilateral common carotid arteries occlusion

(2019) Daniela Impellizzeri et al.   NEUROBIOLOGY OF DISEASE

Co-ultraPEALut: Role in Preclinical and Clinical Delirium Manifestations

(2019) Maria Lia Lunardelli et al.   CNS & Neurological Disorders-Drug Targets

A co-ultramicronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitis

(2019) Gabriella Contarini et al.   Journal of Neuroinflammation

Bioactive lipids ALIAmides differentially modulate inflammatory responses of distinct subsets of primary human T lymphocytes

(2018) Valerio Chiurchiù et al.   FASEB JOURNAL

2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease

(2018) Marika Cordaro et al.   MOLECULAR NEUROBIOLOGY

Effect of PEA-OXA on neuropathic pain and functional recovery after sciatic nerve crush

(2018) Enrico Gugliandolo et al.   Journal of Neuroinflammation

Effects of a new compound containing Palmitoylethanolamide and Baicalein in Myocardial Ischaemia/Reperfusion Injury in VIVO

(2018) Ramona D'amico et al.   PHYTOMEDICINE

N-Palmitoylethanolamine-Oxazoline as a New Therapeutic Strategy to Control Neuroinflammation: Neuroprotective Effects in Experimental Models of Spinal Cord and Brain Injury

(2017) Daniela Impellizzeri et al.   JOURNAL OF NEUROTRAUMA

Co-Ultramicronized Palmitoylethanolamide/Luteolin Facilitates the Development of Differentiating and Undifferentiated Rat Oligodendrocyte Progenitor Cells

(2017) Stephen D. Skaper et al.   MOLECULAR NEUROBIOLOGY

Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury

(2017) Enrico Gugliandolo et al.   PHARMACOLOGICAL RESEARCH

Hemostasis, endothelial stress, inflammation, and the metabolic syndrome

(2017) Gerald Grandl et al.   Seminars in Immunopathology

Effects of a co-micronized composite containing palmitoylethanolamide and polydatin in an experimental model of benign prostatic hyperplasia

(2017) Marika Cordaro et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

2-Pentadecyl-2-Oxazoline, the Oxazoline of Pea, Modulates Carrageenan-Induced Acute Inflammation

(2017) Stefania Petrosino et al.   Frontiers in Pharmacology

Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor

(2017) F. Guida et al.   Scientific Reports

Expression and Differential Responsiveness of Central Nervous System Glial Cell Populations to the Acute Phase Protein Serum Amyloid A

(2017) Massimo Barbierato et al.   Scientific Reports

The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations

(2016) Stefania Petrosino et al.   BRITISH JOURNAL OF PHARMACOLOGY

Beneficial Effects of Co-Ultramicronized Palmitoylethanolamide/Luteolin in a Mouse Model of Autism and in a Case Report of Autism

(2016) Bartolomeo Bertolino et al.   CNS Neuroscience & Therapeutics

A new co-micronized composite containing palmitoylethanolamide and polydatin shows superior oral efficacy compared to their association in a rat paw model of carrageenan-induced inflammation

(2016) E. Esposito et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotective Effects of Co-UltraPEALut on Secondary Inflammatory Process and Autophagy Involved in Traumatic Brain Injury

(2016) Marika Cordaro et al.   JOURNAL OF NEUROTRAUMA

Role of Antioxidants and Natural Products in Inflammation

(2016) Palanisamy Arulselvan et al.   Oxidative Medicine and Cellular Longevity

Dietary Phytochemicals: Natural Swords Combating Inflammation and Oxidation-Mediated Degenerative Diseases

(2016) Md. Asiful Islam et al.   Oxidative Medicine and Cellular Longevity

2-pentadecyl-2-oxazoline: Identification in coffee, synthesis and activity in a rat model of carrageenan-induced hindpaw inflammation

(2016) Daniela Impellizzeri et al.   PHARMACOLOGICAL RESEARCH

Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders

(2016) Fabio Arturo Iannotti et al.   PROGRESS IN LIPID RESEARCH

Co-Ultramicronized Palmitoylethanolamide/Luteolin Promotes Neuronal Regeneration after Spinal Cord Injury

(2016) Rosalia Crupi et al.   Frontiers in Pharmacology

Co-micronized Palmitoylethanolamide/Polydatin Treatment Causes Endometriotic Lesion Regression in a Rodent Model of Surgically Induced Endometriosis

(2016) Rosanna Di Paola et al.   Frontiers in Pharmacology

The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels

(2015) Stefania Petrosino et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates Autophagy in Parkinson’s Disease Model

(2015) Rosalba Siracusa et al.   CNS & Neurological Disorders-Drug Targets

Effects of palmitoylethanolamide and silymarin combination treatment in an animal model of kidney ischemia and reperfusion

(2015) Daniela Impellizzeri et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Peppermint antioxidants revisited

(2015) Liza G. Riachi et al.   FOOD CHEMISTRY

Effectiveness of the Association N-Palmitoylethanolamine and Transpolydatin in the Treatment of Primary Dysmenorrhea

(2015) Edoardo Tartaglia et al.   Journal of Pediatric and Adolescent Gynecology

N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution

(2015) Stephen D. Skaper et al.   MOLECULAR NEUROBIOLOGY

The Association of Palmitoylethanolamide with Luteolin Decreases Autophagy in Spinal Cord Injury

(2015) Rosalba Siracusa et al.   MOLECULAR NEUROBIOLOGY

Co-ultramicronized Palmitoylethanolamide/Luteolin Promotes the Maturation of Oligodendrocyte Precursor Cells

(2015) Massimo Barbierato et al.   Scientific Reports

Co-ultramicronized Palmitoylethanolamide/Luteolin in the Treatment of Cerebral Ischemia: from Rodent to Man

(2015) Carlo Caltagirone et al.   Translational Stroke Research

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Neuroprotection by Association of Palmitoylethanolamide with Luteolin in Experimental Alzheimer’s Disease Models: The Control of Neuroinflammation

(2014) Irene Paterniti et al.   CNS & Neurological Disorders-Drug Targets

Mast cells in chronic inflammation, pelvic pain and depression in women

(2014) Alessandra Graziottin et al.   GYNECOLOGICAL ENDOCRINOLOGY

Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain

(2014) Daniela Impellizzeri et al.   Journal of Neuroinflammation

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Functional and biochemical interaction between PPARα receptors and TRPV1 channels: Potential role in PPARα agonists-mediated analgesia

(2014) Paolo Ambrosino et al.   PHARMACOLOGICAL RESEARCH

Palmitoylethanolamide in CNS health and disease

(2014) Giuseppina Mattace Raso et al.   PHARMACOLOGICAL RESEARCH

Effects of Palmitoylethanolamide and Luteolin in an Animal Model of Anxiety/Depression

(2013) Rosalia Crupi et al.   CNS & Neurological Disorders-Drug Targets

Palmitoylethanolamide in Homeostatic and Traumatic Central Nervous System Injuries

(2013) Emanuela Esposito et al.   CNS & Neurological Disorders-Drug Targets

The adjuvant use of N-palmitoylethanolamine and transpolydatin in the treatment of endometriotic pain

(2013) Emilio Giugliano et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Vestibulodynia

(2013) Filippo Murina et al.   Journal of Lower Genital Tract Disease

A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury

(2013) Irene Paterniti et al.   Journal of Neuroinflammation

Polydatin: A review of pharmacology and pharmacokinetics

(2013) Qiao-Hui Du et al.   PHARMACEUTICAL BIOLOGY

Monoacylglycerols Activate TRPV1 – A Link between Phospholipase C and TRPV1

(2013) Peter M. Zygmunt et al.   PLoS One

Fatty acid composition of membrane bilayers: Importance of diet polyunsaturated fat balance

(2012) Sarah K. Abbott et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Activation and desensitization of TRPV1 channels in sensory neurons by the PPARα agonist palmitoylethanolamide

(2012) Paolo Ambrosino et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity

(2012) Anita R. Alvheim et al.   Obesity

Polydatin protects learning and memory impairments in a rat model of vascular dementia

(2012) Run-Ping Li et al.   PHYTOMEDICINE

Effectiveness of the association micronized N-Palmitoylethanolamine (PEA)–transpolydatin in the treatment of chronic pelvic pain related to endometriosis after laparoscopic assessment: a pilot study

(2011) Luigi Cobellis et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle

(2011) Heather L. Hutchins-Wiese et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations - a comparative bioavailability study of fish oil vs. krill oil

(2011) Jan Schuchardt et al.   Lipids in Health and Disease

Simultaneous measurement of three N-acylethanolamides in human bio-matrices using ultra performance liquid chromatography-tandem mass spectrometry

(2010) Patricia M. W. Lam et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines

(2010) Iain Brown et al.   CARCINOGENESIS

Effect of palmitoylethanolamide–polydatin combination on chronic pelvic pain associated with endometriosis: Preliminary observations

(2010) Ugo Indraccolo et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma

(2010) JodiAnne T. Wood et al.   JOURNAL OF LIPID RESEARCH

Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves

(2009) Rosalia Ferracane et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

A Systemic Review of the Roles of n-3 Fatty Acids in Health and Disease

(2009) Natalie D. Riediger et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Distribution and Biological Activities of the Flavonoid Luteolin

(2009) Miguel Lopez-Lazaro   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Modulation of endothelial nitric oxide by plant-derived products

(2009) Christoph A. Schmitt et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice

(2009) Shoichiro Tsuyama et al.   NUTRITIONAL NEUROSCIENCE

REVIEW ARTICLE: Immunopathogenesis of Pelvic Endometriosis: Role of Hepatocyte Growth Factor, Macrophages and Ovarian Steroids

(2008) Khaleque Newaz Khan et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine

(2008) Andreas Artmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

‘Entourage’ effects ofN-palmitoylethanolamide andN-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors

(2008) W-SV Ho et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis

(2008) Cecilia L. Basiglio et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice

(2008) Gabriella Aviello et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Association of leptin with inflammatory cytokines and lymphocyte subpopulations in peritoneal fluid of patients with endometriosis

(2008) Łukasz Milewski et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Immunosenescence and Immunogenetics of Human Longevity

(2008) R. Ostan et al.   NEUROIMMUNOMODULATION

Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation

(2008) Han-Qing Chen et al.   NEUROSCIENCE LETTERS

Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters

(2008) Jian Du et al.   PHYTOMEDICINE

Effect of polyunsaturated fatty acids on endocannabinoid and N-acyl-ethanolamine levels in mouse adipocytes

(2007) I MATIAS   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences

(2007) J M McPartland et al.   BRITISH JOURNAL OF PHARMACOLOGY