Multidrug Resistance in Neisseria gonorrhoeae: Identification of Functionally Important Residues in the MtrD Efflux Protein

Computer simulations of the activity of RND efflux pumps

(2018) Attilio Vittorio Vargiu et al.   RESEARCH IN MICROBIOLOGY

Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition

(2018) Martijn Zwama et al.   Nature Communications

Mosaic Drug Efflux Gene Sequences from Commensal Neisseria Can Lead to Low-Level Azithromycin Resistance Expressed by Neisseria gonorrhoeae Clinical Isolates

(2018) William M. Shafer   mBio

Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump Locus

(2018) Corinne E. Rouquette-Loughlin et al.   mBio

Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding

(2017) Anandhi Anandan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence of a Substrate-Discriminating Entrance Channel in the Lower Porter Domain of the Multidrug Resistance Efflux Pump AcrB

(2016) Sabine Schuster et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

(2016) Hanno Sjuts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin Substrate

(2016) Abdessamad Ababou et al.   PLoS One

Substrate-dependent dynamics of the multidrug efflux transporter AcrB of Escherichia coli

(2016) Kentaro Yamamoto et al.   Scientific Reports

Structural basis of RND-type multidrug exporters

(2015) Akihito Yamaguchi et al.   Frontiers in Microbiology

Switch-Loop Flexibility Affects Transport of Large Drugs by the Promiscuous AcrB Multidrug Efflux Transporter

(2014) Hi-jea Cha et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other Inhibitors

(2014) Attilio V. Vargiu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Importance of Multidrug Efflux Pumps in the Antimicrobial Resistance Property of Clinical Multidrug-Resistant Isolates of Neisseria gonorrhoeae

(2014) Daniel Golparian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crystal Structure of the Open State of the Neisseria gonorrhoeae MtrE Outer Membrane Channel

(2014) Hsiang-Ting Lei et al.   PLoS One

Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump

(2014) Jani Reddy Bolla et al.   PLoS One

Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump

(2013) Thamarai K. Janganan et al.   MOLECULAR MICROBIOLOGY

Structural basis for the inhibition of bacterial multidrug exporters

(2013) Ryosuke Nakashima et al.   NATURE

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations

(2012) A. V. Vargiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

(2012) T. Eicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Definition and testing of the GROMOS force-field versions 54A7 and 54B7

(2011) Nathan Schmid et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

An Automated Force Field Topology Builder (ATB) and Repository: Version 1.0

(2011) Alpeshkumar K. Malde et al.   Journal of Chemical Theory and Computation

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

(2011) Ryosuke Nakashima et al.   NATURE

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

Substrate path in the AcrB multidrug efflux pump of Escherichia coli

(2010) Fasahath Husain et al.   MOLECULAR MICROBIOLOGY

Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

(2010) Y. Takatsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Rotation of the Transporter AcrB: Insights into Drug Extrusion from Simulations

(2010) Robert Schulz et al.   PLoS Computational Biology

Site-Directed Mutagenesis Reveals Amino Acid Residues in the Escherichia coli RND Efflux Pump AcrB That Confer Macrolide Resistance

(2008) C. Wehmeier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Site-Directed Mutagenesis Reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrB

(2008) J. A. Bohnert et al.   JOURNAL OF BACTERIOLOGY

Optimized production and analysis of the staphylococcal multidrug efflux protein QacA

(2008) Karl A. Hassan et al.   PROTEIN EXPRESSION AND PURIFICATION