Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump Locus

Azithromycin-resistant Neisseria gonorrhoeae spreading amongst men who have sex with men (MSM) and heterosexuals in New South Wales, Australia, 2017

(2018) David M Whiley et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae

(2018) Crista B. Wadsworth et al.   mBio

Mosaic Drug Efflux Gene Sequences from Commensal Neisseria Can Lead to Low-Level Azithromycin Resistance Expressed by Neisseria gonorrhoeae Clinical Isolates

(2018) William M. Shafer   mBio

Control of gdhR Expression in Neisseria gonorrhoeae via Autoregulation and a Master Repressor (MtrR) of a Drug Efflux Pump Operon

(2017) Corinne E. Rouquette-Loughlin et al.   mBio

Genomic Epidemiology and Molecular Resistance Mechanisms of Azithromycin-Resistant Neisseria gonorrhoeae in Canada from 1997 to 2014

(2016) Walter Demczuk et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Genomic Epidemiology of Gonococcal Resistance to Extended-Spectrum Cephalosporins, Macrolides, and Fluoroquinolones in the United States, 2000–2013

(2016) Yonatan H. Grad et al.   JOURNAL OF INFECTIOUS DISEASES

Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea

(2016) Helen Fifer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees

(2016) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting

(2015) Lori Newman et al.   PLoS One

Importance of Multidrug Efflux Pumps in the Antimicrobial Resistance Property of Clinical Multidrug-Resistant Isolates of Neisseria gonorrhoeae

(2014) Daniel Golparian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future

(2014) M. Unemo et al.   CLINICAL MICROBIOLOGY REVIEWS

A Neisseria gonorrhoeae strain with a meningococcal mtrR sequence

(2014) E. Trembizki et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump

(2014) Jani Reddy Bolla et al.   PLoS One

Antimicrobial Resistance and Molecular Typing of Neisseria gonorrhoeae Isolates in Kyoto and Osaka, Japan, 2010 to 2012: Intensified Surveillance after Identification of the First Strain (H041) with High-Level Ceftriaxone Resistance

(2013) Ken Shimuta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2012 European guideline on the diagnosis and treatment of gonorrhoea in adults

(2013) C Bignell et al.   INTERNATIONAL JOURNAL OF STD & AIDS

Gonococcal antimicrobial resistance in the Western Pacific Region: Table 1

(2013) Monica M Lahra et al.   SEXUALLY TRANSMITTED INFECTIONS

Two decades of the gonococcal antimicrobial surveillance program in South America and the Caribbean: challenges and opportunities

(2013) Jo-Anne R Dillon et al.   SEXUALLY TRANSMITTED INFECTIONS

Trends in antimicrobial resistance inNeisseria gonorrhoeaein the USA: the Gonococcal Isolate Surveillance Project (GISP), January 2006–June 2012

(2013) Robert D Kirkcaldy et al.   SEXUALLY TRANSMITTED INFECTIONS

SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing

(2012) Anton Bankevich et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

The Emerging Threat of Untreatable Gonococcal Infection

(2012) Gail A. Bolan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dueling Regulatory Properties of a Transcriptional Activator (MtrA) and Repressor (MtrR) That Control Efflux Pump Gene Expression in Neisseria gonorrhoeae

(2012) Y. M. Zalucki et al.   mBio

Is Neisseria gonorrhoeae Initiating a Future Era of Untreatable Gonorrhea?: Detailed Characterization of the First Strain with High-Level Resistance to Ceftriaxone

(2011) Makoto Ohnishi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High-Level Cefixime- and Ceftriaxone-Resistant Neisseria gonorrhoeae in France: NovelpenAMosaic Allele in a Successful International Clone Causes Treatment Failure

(2011) Magnus Unemo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

A Novel Mechanism of High-Level, Broad-Spectrum Antibiotic Resistance Caused by a Single Base Pair Change in Neisseria gonorrhoeae

(2011) E. A. Ohneck et al.   mBio

New Mutation in 23S rRNA Gene Associated with High Level of Azithromycin Resistance in Neisseria gonorrhoeae

(2010) P. G. Galarza et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular and Structural Analysis of Mosaic Variants of Penicillin-Binding Protein 2 Conferring Decreased Susceptibility to Expanded-Spectrum Cephalosporins inNeisseria gonorrhoeae: Role of Epistatic Mutations

(2010) Joshua Tomberg et al.   BIOCHEMISTRY

A new bioinformatics analysis tools framework at EMBL-EBI

(2010) M. Goujon et al.   NUCLEIC ACIDS RESEARCH

MtrR Modulates rpoH Expression and Levels of Antimicrobial Resistance in Neisseria gonorrhoeae

(2008) J. P. Folster et al.   JOURNAL OF BACTERIOLOGY

Clinically relevant mutations that cause derepression of theNeisseria gonorrhoeaeMtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance andin vivofitness

(2008) Douglas M. Warner et al.   MOLECULAR MICROBIOLOGY

National surveillance of antimicrobial susceptibility in Neisseria gonorrhoeae in 2005-2006 and recommendations of first-line antimicrobial drugs for gonorrhoea treatment in Russia

(2008) A Kubanova et al.   SEXUALLY TRANSMITTED INFECTIONS