Hypoxia‐inducible factor and bacterial infections in chronic obstructive pulmonary disease

Functional effects of the microbiota in chronic respiratory disease

(2019) Kurtis F Budden et al.   Lancet Respiratory Medicine

IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis

(2019) Malcolm R. Starkey et al.   EUROPEAN RESPIRATORY JOURNAL

IL-6 Drives Neutrophil-Mediated Pulmonary Inflammation Associated with Bacteremia in Murine Models of Colitis

(2018) Sean W. Mateer et al.   AMERICAN JOURNAL OF PATHOLOGY

HIF1A gene rs10873142 polymorphism is associated with risk of chronic obstructive pulmonary disease in a Chinese Han population: a case–control study

(2018) Licheng Wang et al.   BIOSCIENCE REPORTS

E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells

(2018) Lisa Miyashita et al.   EUROPEAN RESPIRATORY JOURNAL

Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma

(2017) Philip M. Hansbro et al.   IMMUNOLOGICAL REVIEWS

MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase–mediated suppression of histone deacetylase 2

(2017) Richard Y. Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Temporal upregulation of host surface receptors provides a window of opportunity for bacterial adhesion and disease

(2017) Rajendra Kc et al.   MICROBIOLOGY-SGM

Pneumococcal infection of respiratory cells exposed to welding fumes; Role of oxidative stress and HIF-1 alpha

(2017) Jonathan Grigg et al.   PLoS One

Microbiomes in respiratory health and disease: An Asia-Pacific perspective

(2017) Sanjay H. Chotirmall et al.   RESPIROLOGY

The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD

(2017) Janice M. Leung et al.   RESPIROLOGY

Profiling cellular and inflammatory changes in the airway wall of mild to moderate COPD

(2017) Mathew S. Eapen et al.   RESPIROLOGY

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

(2017) Lukasz Kedzierski et al.   eLife

Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox

(2017) Mathew Suji Eapen et al.   Expert Review of Respiratory Medicine

The Microbiome and the Respiratory Tract

(2016) Robert P. Dickson et al.   Annual Review of Physiology

The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model

(2016) A G Jarnicki et al.   BRITISH JOURNAL OF PHARMACOLOGY

Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?

(2016) Ronan F. O’Toole et al.   Journal of Translational Medicine

Emerging pathogenic links between microbiota and the gut–lung axis

(2016) Kurtis F. Budden et al.   NATURE REVIEWS MICROBIOLOGY

A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

COPD is characterized by increased detection ofHaemophilus influenzae,Streptococcus pneumoniaeand a deficiency ofBacillusspecies

(2016) Jodie L. Simpson et al.   RESPIROLOGY

Animal models of COPD: What do they tell us?

(2016) Bernadette Jones et al.   RESPIROLOGY

Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency

(2016) Bradley W. Richmond et al.   Nature Communications

Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner

(2016) Hiroki Daijo et al.   Scientific Reports

An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke

(2016) Ronan O'Toole et al.   International Journal of Chronic Obstructive Pulmonary Disease

Cardiac effects of current treatments of chronic obstructive pulmonary disease

(2016) Lies Lahousse et al.   Lancet Respiratory Medicine

Oxidative Stress in Chronic Obstructive Pulmonary Disease: A Lung and Systemic Process

(2016) Stephan F Van Eeden et al.   Canadian Respiratory Journal

TLR2, TLR4 AND MyD88 Mediate Allergic Airway Disease (AAD) and Streptococcus pneumoniae-Induced Suppression of AAD

(2016) Alison N. Thorburn et al.   PLoS One

Targeting PI3K-p110α Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease

(2015) Alan Chen-Yu Hsu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tobacco smoking and all-cause mortality in a large Australian cohort study: findings from a mature epidemic with current low smoking prevalence

(2015) Emily Banks et al.   BMC Medicine

Association Between Pathogens Detected Using Quantitative Polymerase Chain Reaction With Airway Inflammation in COPD at Stable State and Exacerbations

(2015) Bethan L. Barker et al.   CHEST

Risk of COPD with obstruction in active smokers with normal spirometry and reduced diffusion capacity

(2015) Ben-Gary Harvey et al.   EUROPEAN RESPIRATORY JOURNAL

Oral Delivery of Prolyl Hydroxylase Inhibitor

(2015) Ellen Marks et al.   INFLAMMATORY BOWEL DISEASES

A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease

(2015) T J Haw et al.   Mucosal Immunology

The role of hypoxia-inducible factor-1α in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo

(2015) Yuh-Feng Lin et al.   Particle and Fibre Toxicology

Platelet-activating factor receptor (PAFr) is upregulated in small airways and alveoli of smokers and COPD patients

(2015) Shakti Dhar Shukla et al.   RESPIROLOGY

Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma

(2015) Ama-Tawiah Essilfie et al.   THORAX

TB meets COPD: An emerging global co-morbidity in human lung disease

(2015) Ronan F. O'Toole et al.   TUBERCULOSIS

Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung

(2015) Hock L. Tay et al.   PLoS Pathogens

Nontypeable Haemophilus influenzae Induces Sustained Lung Oxidative Stress and Protease Expression

(2015) Paul T. King et al.   PLoS One

Polymeric Immunoglobulin Receptor Down-regulation in Chronic Obstructive Pulmonary Disease. Persistence in the Cultured Epithelium and Role of Transforming Growth Factor-β

(2014) Sophie T. Gohy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Animal models of chronic obstructive pulmonary disease

(2014) Michael Fricker et al.   Expert Opinion on Drug Discovery

Importance of Mast Cell Prss31/Transmembrane Tryptase/Tryptase-γ in Lung Function and Experimental Chronic Obstructive Pulmonary Disease and Colitis

(2014) Philip M. Hansbro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia and Hypoxia-Inducible Factor-1  Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function

(2014) J. Jantsch et al.   JOURNAL OF IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Streptococcus pneumoniae Interacts with pIgR Expressed by the Brain Microvascular Endothelium but Does Not Co-Localize with PAF Receptor

(2014) Federico Iovino et al.   PLoS One

The Effect of Azithromycin in Adults with Stable Neutrophilic COPD: A Double Blind Randomised, Placebo Controlled Trial

(2014) Jodie L. Simpson et al.   PLoS One

Cigarette Smoke Extract Induces a Phenotypic Shift in Epithelial Cells; Involvement of HIF1α in Mesenchymal Transition

(2014) Irene M. J. Eurlings et al.   PLoS One

Bronchial platelet-activating factor receptor in chronic obstructive pulmonary disease

(2014) Reetika Suri et al.   RESPIRATORY MEDICINE

Airway epithelial platelet-activating factor receptor expression is markedly upregulated in chronic obstructive pulmonary disease

(2014) Shakti Shukla et al.   International Journal of Chronic Obstructive Pulmonary Disease

Murine models of infectious exacerbations of airway inflammation

(2013) Malcolm Ronald Starkey et al.   CURRENT OPINION IN PHARMACOLOGY

A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis

(2013) Emma L. Beckett et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pneumococcal Components Induce Regulatory T Cells That Attenuate the Development of Allergic Airways Disease by Deviating and Suppressing the Immune Response to Allergen

(2013) A. N. Thorburn et al.   JOURNAL OF IMMUNOLOGY

Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD

(2013) Jodie L. Simpson et al.   MEDIATORS OF INFLAMMATION

Respiratory symptoms and illness in older Australians: the Burden of Obstructive Lung Disease (BOLD) study

(2013) Brett G Toelle et al.   MEDICAL JOURNAL OF AUSTRALIA

Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis

(2013) S Keely et al.   Mucosal Immunology

Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle

(2012) Vladimir T. Basic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Effect of Bronchial Colonisation on Airway and Systemic Inflammation in Stable COPD

(2012) Alicia Marin et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Microbial Modulation of Host Immunity with the Small Molecule Phosphorylcholine

(2012) Sarah E. Clark et al.   INFECTION AND IMMUNITY

Components of Streptococcus pneumoniae Suppress Allergic Airways Disease and NKT Cells by Inducing Regulatory T Cells

(2012) A. N. Thorburn et al.   JOURNAL OF IMMUNOLOGY

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

Changes in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPD

(2012) Davinder S Garcha et al.   THORAX

CombinedHaemophilus influenzaerespiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma

(2012) Ama-Tawiah Essilfie et al.   THORAX

The platelet activating factor receptor: a new anti-infective target in respiratory disease?: Figure 1

(2012) Jonathan Grigg   THORAX

Passing the baton: the HIF switch

(2012) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phosphorylcholine Allows for Evasion of Bactericidal Antibody by Haemophilus influenzae

(2012) Sarah E. Clark et al.   PLoS Pathogens

Concentration of Reactive Oxygen Species (ROS) in Mainstream and Sidestream Cigarette Smoke

(2011) Jiayuan Zhao et al.   AEROSOL SCIENCE AND TECHNOLOGY

Hypoxia affects dendritic cell survival: Role of the hypoxia-inducible factor-1α and lipopolysaccharide

(2011) Antonella Naldini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pulmonary-intestinal cross-talk in mucosal inflammatory disease

(2011) S Keely et al.   Mucosal Immunology

Effects of cigarette smoke and chronic hypoxia on airways remodeling and resistance. Clinical significance

(2011) Elena Olea et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Haemophilus influenzae Infection Drives IL-17-Mediated Neutrophilic Allergic Airways Disease

(2011) Ama-Tawiah Essilfie et al.   PLoS Pathogens

Activation of hypoxia-inducible factor-1  via nuclear factor- B in rats with chronic obstructive pulmonary disease

(2010) H. Jiang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Prevalence of genetic differences in phosphorylcholine expression between nontypeable Haemophilus influenzae and Haemophilus haemolyticus

(2010) Kirk W McCrea et al.   BMC MICROBIOLOGY

Hypoxia inducible factor-1  in human emphysema lung tissue

(2010) M. Yasuo et al.   EUROPEAN RESPIRATORY JOURNAL

Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells

(2010) J. A. Preston et al.   EUROPEAN RESPIRATORY JOURNAL

Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia

(2010) Lisa G. Wood et al.   FREE RADICAL RESEARCH

Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease

(2010) Jason W. Rosch et al.   JOURNAL OF CLINICAL INVESTIGATION

An Intact Canonical NF- B Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia

(2010) S. F. Fitzpatrick et al.   JOURNAL OF IMMUNOLOGY

Pneumococcal pathogenesis: “innate invasion” yet organ-specific damage

(2010) Justin A. Thornton et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxia Inducible Factor-1alpha and Vascular Endothelial Growth Factor in Biopsies of Small Cell Lung Carcinoma

(2009) M. Ioannou et al.   LUNG

Hypoxia-inducible Factor-dependent Regulation of Platelet-activating Factor Receptor as a Route for Gram-Positive Bacterial Translocation across Epithelia

(2009) Simon Keely et al.   MOLECULAR BIOLOGY OF THE CELL

Where is the supporting evidence for treating mild to moderate chronic obstructive pulmonary disease exacerbations with antibiotics? A systematic review

(2008) Milo A Puhan et al.   BMC Medicine

Novel Phosphorylcholine‐Containing Protein ofPseudomonas aeruginosaChronic Infection Isolates Interacts with Airway Epithelial Cells

(2008) Mariette Barbier et al.   JOURNAL OF INFECTIOUS DISEASES

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease

(2008) Sanjay Sethi et al.   NEW ENGLAND JOURNAL OF MEDICINE