Blood-Related Toxicity after Traumatic Brain Injury: Potential Targets for Neuroprotection

Bilirubin and Ischemic Stroke: Rendering the Current Paradigm to Better Understand the Protective Effects of Bilirubin

(2019) Mrugesh Thakkar et al.   MOLECULAR NEUROBIOLOGY

Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage: results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study

(2018) James Galea et al.   JOURNAL OF NEUROSURGERY

Unique properties associated with the brain penetrant iron chelator HBED reveal remarkable beneficial effects after brain trauma

(2018) Saher Khalaf et al.   JOURNAL OF NEUROTRAUMA

Haemoglobin scavenging in intracranial bleeding: biology and clinical implications

(2018) Diederik Bulters et al.   Nature Reviews Neurology

Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation

(2017) Coralie Brifault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective strategies following intraparenchymal hemorrhage

(2017) Robin Moshe Babadjouni et al.   Journal of NeuroInterventional Surgery

Role for RIP1 in mediating necroptosis in experimental intracerebral hemorrhage model both in vivo and in vitro

(2017) Haitao Shen et al.   Cell Death & Disease

Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of ‘soluble CD163’ in plasma

(2017) Anders Etzerodt et al.   Scientific Reports

Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis

(2017) Inês B. Santarino et al.   Scientific Reports

Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis

(2016) Christian A. Schaer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil depletion after subarachnoid hemorrhage improves memory via NMDA receptors

(2016) Jose Javier Provencio et al.   BRAIN BEHAVIOR AND IMMUNITY

Mechanism and Therapy of Brain Edema after Intracerebral Hemorrhage

(2016) Haiping Zheng et al.   CEREBROVASCULAR DISEASES

Role of PDGF-D and PDGFR-β in neuroinflammation in experimental ICH mice model

(2016) Peng Yang et al.   EXPERIMENTAL NEUROLOGY

Macrophages and Iron Metabolism

(2016) Miguel P. Soares et al.   IMMUNITY

Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage

(2016) Jenna L Leclerc et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Haptoglobin increases the vulnerability of CD163-expressing neurons to hemoglobin

(2016) Jing Chen-Roetling et al.   JOURNAL OF NEUROCHEMISTRY

Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage

(2016) Bo Ma et al.   Journal of Neuroinflammation

CD163 promotes hematoma absorption and improves neurological functions in patients with intracerebral hemorrhage

(2016) Qun Liu et al.   Neural Regeneration Research

Haptoglobin 2-2 Genotype Is Associated With Cerebral Salt Wasting Syndrome in Aneurysmal Subarachnoid Hemorrhage

(2016) Santosh B. Murthy et al.   NEUROSURGERY

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

(2016) Xiaochun Duan et al.   Oxidative Medicine and Cellular Longevity

Stages of the Inflammatory Response in Pathology and Tissue Repair after Intracerebral Hemorrhage

(2016) Michael Askenase et al.   SEMINARS IN NEUROLOGY

Heme–Hemopexin Scavenging Is Active in the Brain and Associates With Outcome After Subarachnoid Hemorrhage

(2016) Patrick Garland et al.   STROKE

Brain iron overload following intracranial haemorrhage

(2016) Thomas Garton et al.   JOURNAL OF INVESTIGATIVE MEDICINE

A combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage

(2016) Guang Yang et al.   Scientific Reports

Microglia inflict delayed brain injury after subarachnoid hemorrhage

(2015) Ulf C. Schneider et al.   ACTA NEUROPATHOLOGICA

The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis

(2015) Yang Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Serum ferritin correlates with Glasgow coma scale scores and fatal outcome after severe traumatic brain injury

(2015) Daniel Simon et al.   BRAIN INJURY

Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production

(2015) C J Kearney et al.   CELL DEATH AND DIFFERENTIATION

Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity

(2015) Jeremy W. Deuel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand—Relevance to Subarachnoid Hemorrhage

(2015) Min Kwon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intraventricular Fibrinolysis with Tissue Plasminogen Activator is Associated with Transient Cerebrospinal Fluid Inflammation: A Randomized Controlled Trial

(2015) Andreas H Kramer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1

(2015) Nils Schallner et al.   JOURNAL OF CLINICAL INVESTIGATION

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

Targeting secondary injury in intracerebral haemorrhage—perihaematomal oedema

(2015) Sebastian Urday et al.   Nature Reviews Neurology

Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage

(2015) Jenna L. Leclerc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 and acute brain injury

(2015) Katie N. Murray et al.   Frontiers in Cellular Neuroscience

Presence of Haptoglobin-2 Allele Is Associated with Worse Functional Outcomes After Spontaneous Intracerebral Hemorrhage

(2015) Santosh B. Murthy et al.   World Neurosurgery

Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders

(2015) Ann Smith et al.   Frontiers in Physiology

Immune cells subpopulations in cerebrospinal fluid and peripheral blood of patients with Aneurysmal Subarachnoid Hemorrhage

(2015) Leandro Moraes et al.   SpringerPlus

The Clinical Effect of Deferoxamine Mesylate on Edema after Intracerebral Hemorrhage

(2015) Yao Yu et al.   PLoS One

Heme oxygenase-1 and anti-inflammatory M2 macrophages

(2014) Yuji Naito et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

CD36-Mediated Hematoma Absorption following Intracerebral Hemorrhage: Negative Regulation by TLR4 Signaling

(2014) H. Fang et al.   JOURNAL OF IMMUNOLOGY

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

(2014) Douglas B. Kell et al.   Metallomics

Brain Iron Metabolism and Brain Injury Following Subarachnoid Hemorrhage: iCeFISH-Pilot (CSF Iron in SAH)

(2014) Joao A. Gomes et al.   Neurocritical Care

Choice for the removal of bloody cerebrospinal fluid in postcoiling aneurismal subarachnoid hemorrhage: external ventricular drainage or lumbar drainage?

(2014) Li Hongyu   Turkish Neurosurgery

An Update on Inflammation in the Acute Phase of Intracerebral Hemorrhage

(2014) Sheng Chen et al.   Translational Stroke Research

Heme on innate immunity and inflammation

(2014) Fabianno F. Dutra et al.   Frontiers in Pharmacology

Haptoglobin 2 allele associates with unstable carotid plaque and major cardiovascular events

(2013) Petra Ijäs et al.   ATHEROSCLEROSIS

Hemopexin induces neuroprotection in the rat subjected to focal cerebral ischemia

(2013) Beibei Dong et al.   BMC NEUROSCIENCE

Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage

(2013) C A Schaer et al.   CELL DEATH AND DIFFERENTIATION

The pathophysiology of traumatic brain injury at a glance

(2013) M. Prins et al.   Disease Models & Mechanisms

Genetic Elimination of eNOS Reduces Secondary Complications of Experimental Subarachnoid Hemorrhage

(2013) Mohammed Sabri et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CD163 and IgG Codefend against Cytotoxic Hemoglobin via Autocrine and Paracrine Mechanisms

(2013) K. Subramanian et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states

(2013) Peter Hahl et al.   JOURNAL OF NEUROCHEMISTRY

The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage

(2013) Khalid A Hanafy   Journal of Neuroinflammation

Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury

(2013) Huang Fang et al.   Journal of Neuroinflammation

Haptoglobin genotype and functional outcome after aneurysmal subarachnoid hemorrhage

(2013) Ellen Kantor et al.   JOURNAL OF NEUROSURGERY

The Presence and Role of Iron in Mild Traumatic Brain Injury: An Imaging Perspective

(2013) Eric J. Nisenbaum et al.   JOURNAL OF NEUROTRAUMA

Haptoglobin Phenotype Predicts Cerebral Vasospasm and Clinical Deterioration after Aneurysmal Subarachnoid Hemorrhage

(2013) Hiroyuki Ohnishi et al.   Journal of Stroke & Cerebrovascular Diseases

High Dose Deferoxamine in Intracerebral Hemorrhage (Hi-Def) Trial: Rationale, Design, and Methods

(2013) Sharon D. Yeatts et al.   Neurocritical Care

The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging

(2013) Jens Haugbølle Thomsen et al.   Oxidative Medicine and Cellular Longevity

Prospective, Randomized, Open-Label Phase II Trial on Concomitant Intraventricular Fibrinolysis and Low-Frequency Rotation After Severe Subarachnoid Hemorrhage

(2013) N. Etminan et al.   STROKE

Hematology and Inflammatory Signaling of Intracerebral Hemorrhage

(2013) W. C. Ziai   STROKE

Mechanisms tagging senescent red blood cells for clearance in healthy humans

(2013) Hans U. Lutz et al.   Frontiers in Physiology

Haptoglobin Binding Stabilizes Hemoglobin Ferryl Iron and the Globin Radical on Tyrosine β145

(2012) Chris E. Cooper et al.   ANTIOXIDANTS & REDOX SIGNALING

Plasma Clearance of Hemoglobin and Haptoglobin in Mice and Effect of CD163 Gene Targeting Disruption

(2012) Anders Etzerodt et al.   ANTIOXIDANTS & REDOX SIGNALING

Lesional Accumulation of CD163+ Macrophages/microglia in Rat Traumatic Brain Injury

(2012) Zhiren Zhang et al.   BRAIN RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Pharmacokinetic and Pharmacodynamic Properties of Canakinumab, a Human Anti-Interleukin-1β Monoclonal Antibody

(2012) Abhijit Chakraborty et al.   CLINICAL PHARMACOKINETICS

CD36 as a Therapeutic Target for Endothelial Dysfunction in Stroke

(2012) Sunghee Cho   CURRENT PHARMACEUTICAL DESIGN

Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology

(2012) A. D. Greenhalgh et al.   Disease Models & Mechanisms

Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions

(2012) Sambuddha Banerjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage

(2012) James Galea et al.   JOURNAL OF NEUROCHEMISTRY

Increased expression of Toll-like receptors 2 and 4 is associated with poor outcome in intracerebral hemorrhage

(2012) Manuel Rodríguez-Yáñez et al.   JOURNAL OF NEUROIMMUNOLOGY

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

(2012) Sen Lin et al.   Journal of Neuroinflammation

Elevated serum haptoglobin after traumatic brain injury is synthesized mainly in liver

(2012) Shuguang Yang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cross Talk between Engulfment Receptors Stabilin-2 and Integrin  v 5 Orchestrates Engulfment of Phosphatidylserine-Exposed Erythrocytes

(2012) S. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure of the haptoglobin–haemoglobin complex

(2012) Christian Brix Folsted Andersen et al.   NATURE

Increased expression of ferritin in cerebral cortex after human traumatic brain injury

(2012) Huan-Dong Liu et al.   NEUROLOGICAL SCIENCES

Comparison of the Kinetics of Maturation of Phagosomes Containing Apoptotic Cells and IgG-Opsonized Particles

(2012) Michelle S. Viegas et al.   PLoS One

Lumbar Drainage of Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage

(2012) Yahia Z. Al-Tamimi et al.   STROKE

Signaling in Innate Immunity and Inflammation

(2012) K. Newton et al.   Cold Spring Harbor Perspectives in Biology

Mechanism for phosphatidylserine-dependent erythrophagocytosis in mouse liver

(2011) S.-J. Lee et al.   BLOOD

Toll-like receptors in inflammation of the central nervous system

(2011) Yan Kong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Method of Aneurysm Treatment Does Not Affect Clot Clearance After Aneurysmal Subarachnoid Hemorrhage

(2011) George M. Ibrahim et al.   NEUROSURGERY

Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins

(2011) Christopher C. Leonardo et al.   NUTRITIONAL NEUROSCIENCE

Soluble CD163

(2011) Holger J. Møller   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Safety and Tolerability of Deferoxamine Mesylate in Patients With Acute Intracerebral Hemorrhage

(2011) Magdy Selim et al.   STROKE

Molecular Pathophysiology of Cerebral Hemorrhage

(2011) Jaroslaw Aronowski et al.   STROKE

Regulation of interleukin-1 in acute brain injury

(2011) David Brough et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

EARLYDRAIN- outcome after early lumbar CSF-drainage in aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial

(2011) Jürgen Bardutzky et al.   Trials

c-Jun N-Terminal Kinase Pathway Inhibition in Intracerebral Hemorrhage

(2010) Delphine Michel-Monigadon et al.   CEREBROVASCULAR DISEASES

Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1

(2010) Hyun-Hee Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intravenous Anakinra can Achieve Experimentally Effective Concentrations in the Central Nervous System within a Therapeutic Time Window: Results of a Dose-Ranging Study

(2010) James Galea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

HMBG1 Mediates Ischemia—Reperfusion Injury by TRIF-Adaptor Independent Toll-Like Receptor 4 Signaling

(2010) Qing-Wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tumor necrosis factor α-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163

(2010) Anders Etzerodt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice

(2010) Lifen Chen et al.   JOURNAL OF NEUROSURGERY

Traumatic Brain Injury: A Disease Process, Not an Event

(2010) Brent E. Masel et al.   JOURNAL OF NEUROTRAUMA

Proteomic Identification of Haptoglobin α2 as a Glioblastoma Serum Biomarker: Implications in Cancer Cell Migration and Tumor Growth

(2010) Durairaj Mohan Kumar et al.   JOURNAL OF PROTEOME RESEARCH

Activation of TLR4-Mediated NFB Signaling in Hemorrhagic Brain in Rats

(2010) Weiyu Teng et al.   MEDIATORS OF INFLAMMATION

Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities

(2010) Jiankun Zhu et al.   MEDIATORS OF INFLAMMATION

Locally-administered Intrathecal Thrombolytics Following Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis

(2010) Andreas H. Kramer et al.   Neurocritical Care

Interleukin-1 (IL-1) Pathway

(2010) A. Weber et al.   Science Signaling

Heme Scavenging and the Other Facets of Hemopexin

(2009) Emanuela Tolosano et al.   ANTIOXIDANTS & REDOX SIGNALING

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

(2009) P. W. Buehler et al.   BLOOD

Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging

(2009) M. J. Nielsen et al.   BLOOD

Haptoglobin phenotype and apolipoprotein E polymorphism: Relationship to posttraumatic seizures and neuropsychological functioning after traumatic brain injury

(2009) Gail D. Anderson et al.   EPILEPSY & BEHAVIOR

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

(2009) Felicitas S. Boretti et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroprotective Role of Haptoglobin after Intracerebral Hemorrhage

(2009) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Intracerebral haemorrhage

(2009) Adnan I Qureshi et al.   LANCET

Cerebral microbleeds: a guide to detection and interpretation

(2009) Steven M Greenberg et al.   LANCET NEUROLOGY

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

CSF Neutrophils Are Implicated in the Development of Vasospasm in Subarachnoid Hemorrhage

(2009) J. J. Provencio et al.   Neurocritical Care

Activation of TLR4/NF-κB signaling pathway in early brain injury after subarachnoid hemorrhage

(2009) Chun-Xiao Ma et al.   NEUROLOGICAL RESEARCH

Significance of perihematomal edema in acute intracerebral hemorrhage: The INTERACT trial

(2009) H. Arima et al.   NEUROLOGY

Activation of antibacterial autophagy by NADPH oxidases

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ac-YVAD-CMK Decreases Blood–Brain Barrier Degradation by Inhibiting Caspase-1 Activation of Interleukin-1β in Intracerebral Hemorrhage Mouse Model

(2009) Bihua Wu et al.   Translational Stroke Research

Generation of Procoagulant Microparticles in Cerebrospinal Fluid and Peripheral Blood After Traumatic Brain Injury

(2009) Nicolas Morel et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

The pathology of superficial siderosis of the central nervous system

(2008) Arnulf H. Koeppen et al.   ACTA NEUROPATHOLOGICA

TLRs and innate immunity

(2008) B. A. Beutler   BLOOD

Haptoglobin Genotype: A Determinant of Cardiovascular Complication Risk in Type 1 Diabetes

(2008) T. Costacou et al.   DIABETES

Hemin-induced necroptosis involves glutathione depletion in mouse astrocytes

(2008) Melissa D. Laird et al.   FREE RADICAL BIOLOGY AND MEDICINE

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2008) Zerong You et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Temporally resolved differential proteomic analysis of human ventricular CSF for monitoring traumatic brain injury biomarker candidates

(2008) Jörg Hanrieder et al.   JOURNAL OF NEUROSCIENCE METHODS

Identification of Serum Biomarkers in Brain-Injured Adults: Potential for Predicting Elevated Intracranial Pressure

(2008) Georgene Hergenroeder et al.   JOURNAL OF NEUROTRAUMA

Traumatic Coagulopathy: The Effect of Brain Injury

(2008) Casey H. Halpern et al.   JOURNAL OF NEUROTRAUMA

Rate of nitric oxide scavenging by hemoglobin bound to haptoglobin

(2008) Ivan Azarov et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Hematoma Resolution as a Therapeutic Target: The Role of Microglia/Macrophages

(2008) X. Zhao et al.   STROKE

Haptoglobin, inflammation and disease

(2008) Isaac K. Quaye   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE