DNA replication and homologous recombination factors: acting together to maintain genome stability

Cdc45 Protein-Single-stranded DNA Interaction Is Important for Stalling the Helicase during Replication Stress

(2013) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases

(2013) W.-H. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CMG (CDC45/RecJ, MCM, GINS) complex is a conserved component of the DNA replication system in all archaea and eukaryotes

(2012) Kira S Makarova et al.   Biology Direct

Mechanisms of replication fork protection: a safeguard for genome stability

(2012) Alessia Errico et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Activation of the replicative DNA helicase: breaking up is hard to do

(2012) Dominik Boos et al.   CURRENT OPINION IN CELL BIOLOGY

Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components

(2012) Mai Kanke et al.   EMBO JOURNAL

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

(2012) Frederick van Deursen et al.   EMBO JOURNAL

A Conserved Motif in the C-terminal Tail of DNA Polymerase α Tethers Primase to the Eukaryotic Replisome

(2012) Mairi L. Kilkenny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recombination-restarted replication makes inverted chromosome fusions at inverted repeats

(2012) Ken’Ichi Mizuno et al.   NATURE

Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex

(2012) I. Ilves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase   in rolling circle DNA synthesis

(2012) Y.-H. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote

(2012) Artem Y. Lyubimov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc45: the missing RecJ ortholog in eukaryotes?

(2011) Luis Sanchez-Pulido et al.   BIOINFORMATICS

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

(2011) Yu V. Fu et al.   CELL

X-ray structure of the complex of regulatory subunits of human DNA polymerase delta

(2011) Andrey G. Baranovskiy et al.   CELL CYCLE

The nuts and bolts of ring-translocase structure and mechanism

(2011) Artem Y Lyubimov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural and Functional Insights into the DNA Replication Factor Cdc45 Reveal an Evolutionary Relationship to the DHH Family of Phosphoesterases

(2011) Ivet Krastanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Studies on Human DNA Polymerase ϵ and GINS Complex and Their Role in DNA Replication

(2011) Vladimir P. Bermudez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Histone Chaperone FACT: Structural Insights and Mechanisms for Nucleosome Reorganization

(2011) Duane D. Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Histone Chaperone Facilitates Chromatin Transcription (FACT) Protein Maintains Normal Replication Fork Rates

(2011) Takuya Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

(2011) Daili J A Netz et al.   Nature Chemical Biology

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks

(2011) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

(2011) Alessandro Costa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel DNA nuclease is stimulated by association with the GINS complex

(2011) Zhuo Li et al.   NUCLEIC ACIDS RESEARCH

Flexible tethering of primase and DNA Pol α in the eukaryotic primosome

(2011) Rafael Núñez-Ramírez et al.   NUCLEIC ACIDS RESEARCH

Break-Induced Replication Is Highly Inaccurate

(2011) Angela Deem et al.   PLOS BIOLOGY

The p12 Subunit of Human Polymerase δ Modulates the Rate and Fidelity of DNA Synthesis

(2010) Xiao Meng et al.   BIOCHEMISTRY

Break-induced replication: What is it and what is it for?

(2010) Bertrand Llorente et al.   CELL CYCLE

CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol  , and GINS in budding yeast

(2010) S. Muramatsu et al.   GENES & DEVELOPMENT

Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly

(2010) J. R. Lydeard et al.   GENES & DEVELOPMENT

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

(2010) K. Labib   GENES & DEVELOPMENT

DNA Replication: Making Two Forks from One Prereplication Complex

(2010) Michael Botchan et al.   MOLECULAR CELL

Uncoupling of Sister Replisomes during Eukaryotic DNA Replication

(2010) Hasan Yardimci et al.   MOLECULAR CELL

Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange

(2010) Sarah Lambert et al.   MOLECULAR CELL

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 ‘gate’

(2010) Matthew L. Bochman et al.   NUCLEIC ACIDS RESEARCH

Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion

(2010) W. M. Hicks et al.   SCIENCE

The eukaryotic replicative DNA polymerases take shape

(2010) Erik Johansson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol ε and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors

(2009) Tahir H Tahirov et al.   Biology Direct

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

Tipin/Tim1/And1 protein complex promotes Polα chromatin binding and sister chromatid cohesion

(2009) Alessia Errico et al.   EMBO JOURNAL

3D architecture of DNA Pol α reveals the functional core of multi-subunit replicative polymerases

(2009) Sebastian Klinge et al.   EMBO JOURNAL

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome

(2009) Agnieszka Gambus et al.   EMBO JOURNAL

Dealing with dangerous accidents: DNA double-strand breaks take centre stage. Symposium on Genome Instability and DNA Repair

(2009) Vincenzo Costanzo et al.   EMBO REPORTS

Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism

(2009) K. Mizuno et al.   GENES & DEVELOPMENT

Ctf4 coordinates the progression of helicase and DNA polymerase α

(2009) Hirokazu Tanaka et al.   GENES TO CELLS

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ

(2009) Michael K Swan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intersubunit allosteric communication mediated by a conserved loop in the MCM helicase

(2009) E. R. Barry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

(2009) J.-S. Im et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

(2008) Jeffrey Buis et al.   CELL

Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks

(2008) M. Segurado et al.   GENES & DEVELOPMENT

Division of Labor at the Eukaryotic Replication Fork

(2008) Stephanie A. Nick McElhinny et al.   MOLECULAR CELL

Mrc1 and DNA Polymerase ɛ Function Together in Linking DNA Replication and the S Phase Checkpoint

(2008) Huiqiang Lou et al.   MOLECULAR CELL

The Mcm2-7 Complex Has In Vitro Helicase Activity

(2008) Matthew L. Bochman et al.   MOLECULAR CELL

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51

(2008) Xinyi Su et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The solution structure of the amino-terminal domain of human DNA polymerase ε subunit B is homologous to C-domains of AAA+ proteins

(2008) Tarmo Nuutinen et al.   NUCLEIC ACIDS RESEARCH

DNA damage alters DNA polymerase   to a form that exhibits increased discrimination against modified template bases and mismatched primers

(2008) X. Meng et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of a near-full-length archaeal MCM: Functional insights for an AAA+ hexameric helicase

(2008) A. S. Brewster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA