Carbohydrates as T-cell antigens with implications in health and disease

Sugar-Protein Connectivity Impacts on the Immunogenicity of Site-SelectiveSalmonellaO-Antigen Glycoconjugate Vaccines

(2015) Giuseppe Stefanetti et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click Chemistry Applied to the Synthesis of Salmonella Typhimurium O-Antigen Glycoconjugate Vaccine on Solid Phase with Sugar Recycling

(2015) Giuseppe Stefanetti et al.   BIOCONJUGATE CHEMISTRY

Purification and characterization of aShigellaconjugate vaccine, produced by glycoengineeringEscherichia coli

(2015) Neil Ravenscroft et al.   GLYCOBIOLOGY

Tyrosine-Directed Conjugation of Large Glycans to Proteins via Copper-Free Click Chemistry

(2014) Alberto Nilo et al.   BIOCONJUGATE CHEMISTRY

Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells

(2014) Dingding An et al.   CELL

Plasmacytoid Dendritic Cells Mediate Anti-inflammatory Responses to a Gut Commensal Molecule via Both Innate and Adaptive Mechanisms

(2014) Suryasarathi Dasgupta et al.   Cell Host & Microbe

Glycoconjugate vaccines: an update

(2014) Mairi Vella et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activation

(2014) J. L. Johnson et al.   GLYCOBIOLOGY

Polysaccharide A from the Capsule ofBacteroides fragilisInduces Clonal CD4+T Cell Expansion

(2014) Jenny L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved Mycobacterial Lipoglycoproteins Activate TLR2 but Also Require Glycosylation for MHC Class II-Restricted T Cell Activation

(2014) Peter A. Sieling et al.   JOURNAL OF IMMUNOLOGY

IFN-  Regulated Chemokine Production Determines the Outcome of Staphylococcus aureus Infection

(2014) R. M. McLoughlin et al.   JOURNAL OF IMMUNOLOGY

Targeted Delivery of Mycobacterial Antigens to Human Dendritic Cells via Siglec-7 Induces Robust T Cell Activation

(2014) Norihito Kawasaki et al.   JOURNAL OF IMMUNOLOGY

Hijacking bacterial glycosylation for the production of glycoconjugates, from vaccines to humanised glycoproteins

(2014) Jon Cuccui et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice

(2014) Marco Cavallari et al.   Nature Chemical Biology

Improving Mycobacterium bovis Bacillus Calmette-Guèrin as a Vaccine Delivery Vector for Viral Antigens by Incorporation of Glycolipid Activators of NKT Cells

(2014) Manjunatha M. Venkataswamy et al.   PLoS One

Recent Mechanistic Insights on Glycoconjugate Vaccines and Future Perspectives

(2013) Francesco Berti et al.   ACS Chemical Biology

Novel Strategies for Development of Next-Generation Glycoconjugate Vaccines

(2013) Fikri Avci   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Bacterial ProteinN-Glycosylation: New Perspectives and Applications

(2013) Harald Nothaft et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptive immune activation: glycosylation does matter

(2013) Margreet A Wolfert et al.   Nature Chemical Biology

Carbohydrates and T cells: A sweet twosome

(2013) Fikri Y. Avci et al.   SEMINARS IN IMMUNOLOGY

O-mannosylation of the Mycobacterium tuberculosis Adhesin Apa Is Crucial for T Cell Antigenicity during Infection but Is Expendable for Protection

(2013) Subhadra Nandakumar et al.   PLoS Pathogens

Glycobiology of immune responses

(2012) Gabriel A. Rabinovich et al.   Annals of the New York Academy of Sciences

Recent developments in bacterial protein glycan coupling technology and glycoconjugate vaccine design

(2012) V. S. Terra et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Isolation of carbohydrate-specific CD4+ T cell clones from mice after stimulation by two model glycoconjugate vaccines

(2012) Fikri Y Avci et al.   Nature Protocols

The design of semi-synthetic and synthetic glycoconjugate vaccines

(2011) Paolo Costantino et al.   Expert Opinion on Drug Discovery

The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA

(2011) Neeraj K. Surana et al.   IMMUNOLOGICAL REVIEWS

Glycoantigens Induce Human Peripheral Tr1 Cell Differentiation with Gut-homing Specialization

(2011) Lori S. C. Kreisman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design

(2011) Fikri Y Avci et al.   NATURE MEDICINE

Central Nervous System Demyelinating Disease Protection by the Human Commensal Bacteroides fragilis Depends on Polysaccharide A Expression

(2010) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

Production of glycoprotein vaccines in Escherichia coli

(2010) Julian Ihssen et al.   Microbial Cell Factories

Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine

(2010) D. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Bacterial Carbohydrates Influence the Adaptive Immune System

(2009) Fikri Y. Avci et al.   Annual Review of Immunology

The evolved functions of CD1 during infection

(2009) Anne Kasmar et al.   CURRENT OPINION IN IMMUNOLOGY

Glycoimmunology: ignore at your peril!

(2009) Linda G. Baum et al.   IMMUNOLOGICAL REVIEWS

Oligoclonal CD4+ T Cells Promote Host Memory Immune Responses to Zwitterionic Polysaccharide of Streptococcus pneumoniae

(2009) L. Groneck et al.   INFECTION AND IMMUNITY

Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by Vα14 i NKT Cells

(2009) Barbara A. Sullivan et al.   JOURNAL OF IMMUNOLOGY

Virulence factors and their mechanisms of action: the view from a damage–response framework

(2009) Arturo Casadevall et al.   JOURNAL OF WATER AND HEALTH

Antigen processing of glycoconjugate vaccines; the polysaccharide portion of the pneumococcal CRM197 conjugate vaccine co-localizes with MHC II on the antigen processing cell surface

(2009) Zengzu Lai et al.   VACCINE

Alpha-C-galactosylceramide as an adjuvant for a live attenuated influenza virus vaccine

(2009) Sarah A. Kopecky-Bromberg et al.   VACCINE

Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR

(2008) Brian A Cobb et al.   GLYCOBIOLOGY

Type I Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHC II-dependent pathway for antigen presentation

(2008) Christopher D. Velez et al.   IMMUNOLOGY

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Microbial carbohydrate depolymerization by antigen-presenting cells: Deamination prior to presentation by the MHCII pathway

(2008) Jinyou Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseases

(2008) Angela Bardotti et al.   VACCINE

Optimising the use of conjugate vaccines to prevent disease caused by Haemophilus influenzae type b, Neisseria meningitidis and Streptococcus pneumoniae

(2008) Caroline L. Trotter et al.   VACCINE