Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis

Late-onset psoriatic arthritis in Japanese patients

(2019) Toshiyuki Yamamoto et al.   JOURNAL OF DERMATOLOGY

Cross-sectional multicenter observational study of psoriatic arthritis in Japanese patients: Relationship between skin and joint symptoms and results of treatment with tumor necrosis factor-α inhibitors

(2019) Noriko Tsuruta et al.   JOURNAL OF DERMATOLOGY

Secukinumab decreased circulating anti-BP180-NC16a autoantibodies in a patient with coexisting psoriasis vulgaris and bullous pemphigoid

(2019) Masahiro Kamata et al.   JOURNAL OF DERMATOLOGY

Atopic dermatitis is an IL-13 dominant disease with greater molecular heterogeneity compared to psoriasis

(2019) Lam C. Tsoi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytes

(2019) Masutaka Furue et al.   GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

Staphylococcus aureus in atopic dermatitis: Strain-specific cell wall proteins and skin immunity

(2019) Kazumasa Iwamoto et al.   ALLERGOLOGY INTERNATIONAL

Sustainability and switching of biologics for psoriasis and psoriatic arthritis at Fukuoka University Psoriasis Registry

(2019) Bolortuya Bayaraa et al.   JOURNAL OF DERMATOLOGY

The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver

(2019) Melina Mescher et al.   ARCHIVES OF TOXICOLOGY

The contribution of IL-17 to the development of autoimmunity in psoriasis

(2019) Masutaka Furue et al.   Innate Immunity

Patient preference for biologic treatments of psoriasis in Japan

(2019) Yayoi Tada et al.   JOURNAL OF DERMATOLOGY

Cost‐efficacy and pharmacoeconomics of psoriatic patients in Japan: Analysis from a single outpatient clinic

(2019) Hidetoshi Takahashi et al.   JOURNAL OF DERMATOLOGY

Prevalence of inflammatory bowel disease in Japanese psoriatic patients

(2019) Saori Masaki et al.   JOURNAL OF DERMATOLOGY

Psoriasis is associated with increased risk of bullous pemphigoid: A nationwide population‐based cohort study in Taiwan

(2019) Yi‐Hsin Ho et al.   JOURNAL OF DERMATOLOGY

Health-care resource use and current treatment of adult atopic dermatitis patients in Japan: A retrospective claims database analysis

(2019) Atsuyuki Igarashi et al.   JOURNAL OF DERMATOLOGY

Increased risk of psoriasis in subjects with abdominal obesity: A nationwide population‐based study

(2019) Ju Hee Han et al.   JOURNAL OF DERMATOLOGY

Aryl Hydrocarbon Receptor Directly Regulates Artemin Gene Expression

(2019) Tomohiro Edamitsu et al.   MOLECULAR AND CELLULAR BIOLOGY

Psoriasis and the TNF/IL23/IL17 axis

(2019) Kazuhisa Furue et al.   GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

IL-4 Augments IL-31/IL-31 Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22 Production in Dendritic Cells: Implications for Atopic Dermatitis

(2019) Sho Miake et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antioxidative Phytochemicals Accelerate Epidermal Terminal Differentiation via the AHR-OVOL1 Pathway: Implications for Atopic Dermatitis

(2018) M Furue et al.   ACTA DERMATO-VENEREOLOGICA

The IL-13/periostin/IL-24 pathway causes epidermal barrier dysfunction in allergic skin inflammation

(2018) Yasutaka Mitamura et al.   ALLERGY

Cytochrome P4501-inhibiting chemicals amplify aryl hydrocarbon receptor activation and IL-22 production in T helper 17 cells

(2018) Chris Schiering et al.   BIOCHEMICAL PHARMACOLOGY

Protective role of peroxisome proliferator-activated receptor α agonists in skin barrier and inflammation

(2018) Kazuhisa Furue et al.   IMMUNOBIOLOGY

Autoimmunity and autoimmune co-morbidities in psoriasis

(2018) Kazuhisa Furue et al.   IMMUNOLOGY

Glyteer, Soybean Tar, Impairs IL-4/Stat6 Signaling in Murine Bone Marrow-Derived Dendritic Cells: The Basis of Its Therapeutic Effect on Atopic Dermatitis

(2018) Masaki Takemura et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1

(2018) Akiko Hashimoto-Hachiya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective role of 6-formylindolo[3,2-b]carbazole (FICZ), an endogenous ligand for arylhydrocarbon receptor, in chronic mite-induced dermatitis

(2018) Mari Kiyomatsu-Oda et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The role of the OVOL1–OVOL2 axis in normal and diseased human skin

(2018) Gaku Tsuji et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Burden of atopic dermatitis in Japanese adults: Analysis of data from the 2013 National Health and Wellness Survey

(2018) Kazuhiko Arima et al.   JOURNAL OF DERMATOLOGY

Current developments in phototherapy for psoriasis

(2018) Akimichi Morita   JOURNAL OF DERMATOLOGY

Assessment of medication adherence and treatment satisfaction in Japanese patients with psoriasis of various severities

(2018) Susumu Ichiyama et al.   JOURNAL OF DERMATOLOGY

Relationship between environmental factors, age of onset and familial history in Japanese patients with psoriasis

(2018) Bolortuya Bayaraa et al.   JOURNAL OF DERMATOLOGY

Microbiome analysis of forehead skin in patients with atopic dermatitis and healthy subjects: Implication of Staphylococcus and Corynebacterium

(2018) Masutaka Furue et al.   JOURNAL OF DERMATOLOGY

Improvement in abnormal coronary arteries estimated by coronary computed tomography angiography after secukinumab treatment in a Japanese psoriatic patient

(2018) Fumikazu Yamazaki et al.   JOURNAL OF DERMATOLOGY

Effects of tumor necrosis factor-α, interleukin-23 and interleukin-17A inhibitors on bodyweight and body mass index in patients with psoriasis

(2018) Saori Takamura et al.   JOURNAL OF DERMATOLOGY

Survey of disease awareness, treatment behavior and treatment satisfaction in patients with atopic dermatitis in Korea: A multicenter study

(2018) Hye Jung Jung et al.   JOURNAL OF DERMATOLOGY

A Phase 2, Randomized Dose-Finding Study of Tapinarof (GSK2894512 Cream) for the Treatment of Atopic Dermatitis

(2018) Johnny Peppers et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway

(2018) Kai Wang et al.   BIOCHEMICAL PHARMACOLOGY

The tryptophan derivative 6-formylindolo[3,2-b]carbazole, FICZ, a dynamic mediator of endogenous aryl hydrocarbon receptor signaling, balances cell growth and differentiation

(2018) Agneta Rannug et al.   CRITICAL REVIEWS IN TOXICOLOGY

Differential efficacy of biologic treatments targeting the TNF-α/IL-23/IL-17 axis in psoriasis and psoriatic arthritis

(2018) Kazuhisa Furue et al.   CYTOKINE

Cutaneous permeability barrier function in signal transducer and activator of transcription 6-deficient mice is superior to that in wild-type mice

(2018) Wei Zhang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Evaluation of epicardial adipose tissue volume and coronary artery calcification in Japanese patients with psoriasis vulgaris

(2018) Mami Momose et al.   JOURNAL OF DERMATOLOGY

Aryl hydrocarbon receptor polymorphisms are associated with dry skin phenotypes in Chinese patients with atopic dermatitis

(2018) Z. Z. Li et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor

(2018) Jinlei Yu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Phenotypes of atopic dermatitis identified by cluster analysis in early childhood

(2018) Euri Seo et al.   JOURNAL OF DERMATOLOGY

Psoriasis is associated with a greater risk for cardiovascular procedure and surgery in patients with hypertension: A nationwide cohort study

(2018) Hsien-Yi Chiu et al.   JOURNAL OF DERMATOLOGY

Improvement of nail lesions in a patient with psoriatic arthritis by switching the treatment from an anti-interleukin-17A antibody to an anti-tumor necrosis factor-α antibody

(2018) Takayoshi Komatsu-Fujii et al.   JOURNAL OF DERMATOLOGY

Psoriasis vulgaris associated with systemic lupus erythematosus successfully treated with apremilast

(2018) Susumu Ichiyama et al.   JOURNAL OF DERMATOLOGY

Expanded Genome-Wide Association Study Meta-Analysis of Psoriasis Expands the Catalog of Common Psoriasis-Associated Variants

(2018) James T. Elder   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

A Phase 2, Randomized Dose-Finding Study of Tapinarof (GSK2894512 Cream) for the Treatment of Plaque Psoriasis

(2018) Kevin Robbins et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Tryptophan Photoproduct FICZ Upregulates IL1A, IL1B, and IL6 Expression via Oxidative Stress in Keratinocytes

(2018) Yuka Tanaka et al.   Oxidative Medicine and Cellular Longevity

“Inflammatory skin march” in atopic dermatitis and psoriasis

(2017) Masutaka Furue et al.   INFLAMMATION RESEARCH

Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway

(2017) Akiko Hirano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epidemiological survey from 2009 to 2012 of psoriatic patients in Japanese Society for Psoriasis Research

(2017) Toshihiro Ito et al.   JOURNAL OF DERMATOLOGY

Economic assessment of actual prescription of drugs for treatment of atopic dermatitis: Differences between dermatology and pediatrics in large-scale receipt data

(2017) Yoko Komura et al.   JOURNAL OF DERMATOLOGY

Epidemiological survey of patients with psoriasis in Matsumoto city, Nagano Prefecture, Japan

(2017) Eisaku Ogawa et al.   JOURNAL OF DERMATOLOGY

Non-corticosteroid adherence and itch severity influence perception of itch in atopic dermatitis

(2017) Satoshi Takeuchi et al.   JOURNAL OF DERMATOLOGY

Safety of biologics in psoriasis

(2017) Masahiro Kamata et al.   JOURNAL OF DERMATOLOGY

New onset of psoriasis during nivolumab treatment for lung cancer

(2017) Satomi Chujo et al.   JOURNAL OF DERMATOLOGY

Pathogenesis of psoriasis and development of treatment

(2017) Eisaku Ogawa et al.   JOURNAL OF DERMATOLOGY

Mouse models of psoriasis and their relevance

(2017) Kimiko Nakajima et al.   JOURNAL OF DERMATOLOGY

Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans

(2017) Susan H. Smith et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Feedback control of AHR signalling regulates intestinal immunity

(2017) Chris Schiering et al.   NATURE

β-Naphthoflavone-Induced Mitochondrial Respiratory Damage in Cyp1 Knockout Mouse and in Cell Culture Systems: Attenuation by Resveratrol Treatment

(2017) Suresh Kumar Anandasadagopan et al.   Oxidative Medicine and Cellular Longevity

TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation

(2017) Allison K Ehrlich et al.   TOXICOLOGICAL SCIENCES

Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis

(2017) Gaku Tsuji et al.   Cell Death & Disease

Antioxidants for Healthy Skin: The Emerging Role of Aryl Hydrocarbon Receptors and Nuclear Factor-Erythroid 2-Related Factor-2

(2017) Masutaka Furue et al.   Nutrients

The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells

(2017) Jian Ye et al.   Cell Reports

Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies

(2017) Masutaka Furue et al.   ALLERGOLOGY INTERNATIONAL

AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model

(2016) Perrine M. Cochez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Benzopyrene, a major polyaromatic hydrocarbon in smoke fume, mobilizes Langerhans cells and polarizes Th2/17 responses in epicutaneous protein sensitization through the aryl hydrocarbon receptor

(2016) Chien-Hui Hong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Use of a dose-response model to guide future clinical trial of benvitimod cream to treat mild and moderate psoriasis

(2016) Yan-Nan Zang et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin

(2016) Takanori Hidaka et al.   NATURE IMMUNOLOGY

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

(2016) Eric L. Simpson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin

(2016) Susan H. Smith et al.   PLoS One

Galactomycesfermentation filtrate prevents T helper 2-mediated reduction of filaggrin in an aryl hydrocarbon receptor-dependent manner

(2015) K. Takei et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor

(2015) Masutaka Furue et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Genetic and Pharmacological Analysis Identifies a Physiological Role for the AHR in Epidermal Differentiation

(2015) Ellen H. van den Bogaard et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

AntioxidantOpuntia ficus-indicaExtract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes

(2015) Takeshi Nakahara et al.   JOURNAL OF MEDICINAL FOOD

Psoriasis

(2015) Wolf-Henning Boehncke et al.   LANCET

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Aryl hydrocarbon receptor SNP –130 C/T associates with dioxins susceptibility through regulating its receptor activity and downstream effectors including interleukin 24

(2015) Ge Liu et al.   TOXICOLOGY LETTERS

Cynaropicrin attenuates UVB-induced oxidative stress via the AhR–Nrf2–Nqo1 pathway

(2015) Kenjiro Takei et al.   TOXICOLOGY LETTERS

The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

(2014) Brigitta Stockinger et al.   Annual Review of Immunology

Role of AhR/ARNT system in skin homeostasis

(2014) Masutaka Furue et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Increased expression of the aryl hydrocarbon receptor in patients with chronic inflammatory skin diseases

(2014) Hye One Kim et al.   EXPERIMENTAL DERMATOLOGY

Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions

(2014) Paola Di Meglio et al.   IMMUNITY

Mammalian Cytochrome P450-Dependent Metabolism of Polychlorinated Dibenzo-p-dioxins and Coplanar Polychlorinated Biphenyls

(2014) Hideyuki Inui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antioxidant soybean tar Glyteer rescues T-helper-mediated downregulation of filaggrin expression via aryl hydrocarbon receptor

(2014) Kenjiro Takei et al.   JOURNAL OF DERMATOLOGY

Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

(2013) Ju Qiu et al.   IMMUNITY

Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis

(2013) Ellen H. van den Bogaard et al.   JOURNAL OF CLINICAL INVESTIGATION

Malassezia Yeasts Produce a Collection of Exceptionally Potent Activators of the Ah (Dioxin) Receptor Detected in Diseased Human Skin

(2013) Prokopios Magiatis et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Functions of the aryl hydrocarbon receptor in the skin

(2013) Charlotte Esser et al.   Seminars in Immunopathology

The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the ‘fused genes’ family

(2012) Magdalini Kypriotou et al.   EXPERIMENTAL DERMATOLOGY

Inhibition of AHR transcription by NF1C is affected by a single-nucleotide polymorphism and is involved in suppression of human uterine endometrial cancer

(2012) D Li et al.   ONCOGENE

2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Production of Reactive Oxygen Species Is An Essential Step in the Mechanism of Action to Accelerate Human Keratinocyte Differentiation

(2012) Lawrence H. Kennedy et al.   TOXICOLOGICAL SCIENCES

Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week, multicentre, randomized, placebo-controlled double-blind trial

(2011) R. Bissonnette et al.   BRITISH JOURNAL OF DERMATOLOGY

2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitro

(2011) Qiang Ju et al.   EXPERIMENTAL DERMATOLOGY

Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract

(2011) Ivan Monteleone et al.   GASTROENTEROLOGY

The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

(2011) Ju Qiu et al.   IMMUNITY

An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway

(2011) Gaku Tsuji et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Identification of Ketoconazole as an AhR-Nrf2 Activator in Cultured Human Keratinocytes: The Basis of Its Anti-Inflammatory Effect

(2011) Gaku Tsuji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Efficacy and safety of topical WBI-1001 in patients with mild to moderate psoriasis: results from a randomized double-blind placebo-controlled, phase II trial

(2011) R. Bissonnette et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

(2011) Jacob S Lee et al.   NATURE IMMUNOLOGY

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

(2011) Carrie Hayes Sutter et al.   TOXICOLOGICAL SCIENCES

Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor

(2011) Michael S. Denison et al.   TOXICOLOGICAL SCIENCES

Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxicities

(2010) C. J. Omiecinski et al.   TOXICOLOGICAL SCIENCES

2,3,7,8-Tetrachlorodibenzo-p-dioxin increases reactive oxygen species production in human endothelial cells via induction of cytochrome P4501A1

(2010) P.G. Kopf et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Anti-psoriatic effects of indigo naturalis on the proliferation and differentiation of keratinocytes with indirubin as the active component

(2009) Yin-Ku Lin et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”

(2009) Ronnie L. Yeager et al.   TOXICOLOGICAL SCIENCES

The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b]carbazole Is Present in Humans

(2008) Emma Wincent et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biopositive Effects of Low-Dose UVB on Epidermis: Coordinate Upregulation of Antimicrobial Peptides and Permeability Barrier Reinforcement

(2008) Seung P. Hong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Is eczema really on the increase worldwide?

(2007) Hywel Williams et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY