Functions of the aryl hydrocarbon receptor in the skin

Malassezia-derived indoles activate the aryl hydrocarbon receptor and inhibit Toll-like receptor-induced maturation in monocyte-derived dendritic cells

(2012) C. Vlachos et al.   BRITISH JOURNAL OF DERMATOLOGY

A novel prenylflavone restricts breast cancer cell growth through AhR-mediated destabilization of ERα protein

(2012) Chi Tze Tiong et al.   CARCINOGENESIS

New insights of T cells in the pathogenesis of psoriasis

(2012) Yihua Cai et al.   Cellular & Molecular Immunology

Cancer Stem Cells and Novel Targets for Antitumor Strategies

(2012) Gerald J. Prud’homme   CURRENT PHARMACEUTICAL DESIGN

Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I)

(2012) Christine Götz et al.   EXPERIMENTAL DERMATOLOGY

Blunted epidermal l-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: epidermal H2O2/ONOO−-mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low serotonin and melatonin levels

(2012) Karin U. Schallreuter et al.   FASEB JOURNAL

Blunted epidermal l-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 2: epidermal H2O2/ONOO−-mediated stress in vitiligo hampers indoleamine 2,3-dioxygenase and aryl hydrocarbon receptor-mediated immune response signaling

(2012) Karin U. Schallreuter et al.   FASEB JOURNAL

Karl Herxheimer - Geheimrat mit dem gelben Stern

(2012) Albrecht Scholz   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

The Aryl Hydrocarbon Receptor Modulates Acute and Late Mast Cell Responses

(2012) R. Sibilano et al.   JOURNAL OF IMMUNOLOGY

EGFR regulation of epidermal barrier function

(2012) Quynh T. Tran et al.   PHYSIOLOGICAL GENOMICS

Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma

(2012) B. G. Modi et al.   SCIENCE

The aryl hydrocarbon receptor influences transplant outcomes in response to environmental signals

(2012) S. Kyle Pauly et al.   TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

AhR deficiency impairs expression of LPS-induced inflammatory genes in mice

(2011) Dalei Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations

(2011) X-W. Wang et al.   BRITISH JOURNAL OF DERMATOLOGY

Discovery and biological characterization of 1-(1H-indol-3-yl)-9H-pyrido[3,4-b]indole as an aryl hydrocarbon receptor activator generated by photoactivation of tryptophan by sunlight

(2011) Silvia Diani-Moore et al.   CHEMICO-BIOLOGICAL INTERACTIONS

2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitro

(2011) Qiang Ju et al.   EXPERIMENTAL DERMATOLOGY

Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease

(2011) Qiang Ma   Expert Opinion on Drug Metabolism & Toxicology

Aryl Hydrocarbon Receptor Is Critical for Homeostasis of Invariant    T Cells in the Murine Epidermis

(2011) S. Kadow et al.   JOURNAL OF IMMUNOLOGY

Identification of a Novel Proinflammatory Human Skin-Homing V 9V 2 T Cell Subset with a Potential Role in Psoriasis

(2011) U. Laggner et al.   JOURNAL OF IMMUNOLOGY

Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts

(2011) Linnéa Asp et al.   Journal of Inflammation-London

The AhR–Nrf2 Pathway in Keratinocytes: On the Road to Chemoprevention?

(2011) Thomas Haarmann-Stemmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Could Malassezia yeasts be implicated in skin carcinogenesis through the production of aryl-hydrocarbon receptor ligands?

(2011) G. Gaitanis et al.   MEDICAL HYPOTHESES

Th22 in inflammatory and autoimmune disease: prospects for therapeutic intervention

(2011) Ning Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

In Vivo Induction of Tr1 Cells via Mucosal Dendritic Cells and AHR Signaling

(2011) Henry Yim Wu et al.   PLoS One

2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

(2011) Carrie Hayes Sutter et al.   TOXICOLOGICAL SCIENCES

The Cutaneous Lesions of Dioxin Exposure: Lessons from the Poisoning of Victor Yushchenko

(2011) Jean-Hilaire Saurat et al.   TOXICOLOGICAL SCIENCES

Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor

(2011) Michael S. Denison et al.   TOXICOLOGICAL SCIENCES

An introduction to the molecular basics of aryl hydrocarbon receptor biology

(2010) Josef Abel et al.   BIOLOGICAL CHEMISTRY

Chloracne: Still Cause for Concern

(2010) Beatrice Passarini et al.   DERMATOLOGY

Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin

(2010) Nikolaus Romani et al.   IMMUNOLOGICAL REVIEWS

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

The Aryl Hydrocarbon Receptor Mediates UVB Radiation–Induced Skin Tanning

(2010) Bettina Jux et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

(2010) Lionel Apetoh et al.   NATURE IMMUNOLOGY

Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells

(2010) Roopali Gandhi et al.   NATURE IMMUNOLOGY

The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis

(2010) Sandra Luecke et al.   Pigment Cell & Melanoma Research

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecules as friends and foes of the immune system

(2009) Stephanie Kadow et al.   Future Medicinal Chemistry

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

AHR activation by tryptophan—Pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia–myalgia-syndrome and toxic oil syndrome?

(2009) Nikolaus Rieber et al.   IMMUNOLOGY LETTERS

Loss of dioxin-receptor expression accelerates wound healing in vivo by a mechanism involving TGF 

(2009) J. M. Carvajal-Gonzalez et al.   JOURNAL OF CELL SCIENCE

Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

(2009) Akihiro Kimura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aryl Hydrocarbon Receptor Activation Inhibits In Vitro Differentiation of Human Monocytes and Langerhans Dendritic Cells

(2009) B. Platzer et al.   JOURNAL OF IMMUNOLOGY

Langerhans Cell Maturation and Contact Hypersensitivity Are Impaired in Aryl Hydrocarbon Receptor-Null Mice

(2009) B. Jux et al.   JOURNAL OF IMMUNOLOGY

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production

(2009) H. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGF receptor signaling blocks aryl hydrocarbon receptor-mediated transcription and cell differentiation in human epidermal keratinocytes

(2009) C. H. Sutter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The aryl hydrocarbon receptor in immunity

(2009) Charlotte Esser et al.   TRENDS IN IMMUNOLOGY

The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations

(2008) Kameshwar P. Singh et al.   BIOCHEMICAL PHARMACOLOGY

Timing is everything: Consequences of transient and sustained AhR activity

(2008) Kristen A. Mitchell et al.   BIOCHEMICAL PHARMACOLOGY

A new cross-talk between the aryl hydrocarbon receptor and RelB, a member of the NF-κB family

(2008) Christoph F.A. Vogel et al.   BIOCHEMICAL PHARMACOLOGY

Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways

(2008) Thomas Haarmann-Stemmann et al.   BIOCHEMICAL PHARMACOLOGY

Association of clinical findings in Yusho patients with serum concentrations of polychlorinated biphenyls, polychlorinated quarterphenyls and 2,3,4,7,8-pentachlorodibenzofuran more than 30 years after the poisoning event

(2008) Yoshiyuki Kanagawa et al.   Environmental Health

The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b]carbazole Is Present in Humans

(2008) Emma Wincent et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

(2008) Marc Veldhoen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AhR Ligands, Malassezin, and Indolo[3,2-b]Carbazole are Selectively Produced by Malassezia furfur Strains Isolated from Seborrheic Dermatitis

(2008) George Gaitanis et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

Community Corner

(2008)   NATURE MEDICINE

Cyclo-oxygenase-2 Plays a Critical Role in UV-induced Skin Carcinogenesis

(2008) Joyce E. Rundhaug et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

TCDD exposure exacerbates atopic dermatitis-related inflammation in NC/Nga mice

(2008) Tomohiro Ito et al.   TOXICOLOGY LETTERS

The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor

(2007) Linh P. Nguyen et al.   CHEMICAL RESEARCH IN TOXICOLOGY