Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxicities

Cutting Edge: TLR2 Is a Functional Receptor for Acute-Phase Serum Amyloid A

(2014) N. Cheng et al.   JOURNAL OF IMMUNOLOGY

The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

(2012) Timothy V. Beischlag et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Expression and Activity of Aryl Hydrocarbon Receptors in Development and Cancer

(2012) Thomas A. Gasiewicz et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Ube2l3 gene expression is modulated by activation of the aryl hydrocarbon receptor: Implications for p53 ubiquitination

(2010) O.D. Reyes-Hernández et al.   BIOCHEMICAL PHARMACOLOGY

Development of a Selective Modulator of Aryl Hydrocarbon (Ah) Receptor Activity that Exhibits Anti-Inflammatory Properties

(2010) Iain A. Murray et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pregnane X Receptor and Constitutive Androstane Receptor at the Crossroads of Drug Metabolism and Energy Metabolism

(2010) J. Gao et al.   DRUG METABOLISM AND DISPOSITION

Dietary Flavonoids Activate the Constitutive Androstane Receptor (CAR)

(2010) Ruiquing Yao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mechanistic Insights into the Events That Lead to Synergistic Induction of Interleukin 6 Transcription upon Activation of the Aryl Hydrocarbon Receptor and Inflammatory Signaling

(2010) Brett C. DiNatale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist

(2010) Barry G. Shearer et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention

(2010) Nina Korzeniewski et al.   Molecular Cancer

A Functional Cross-Talk between Liver X Receptor-  and Constitutive Androstane Receptor Links Lipogenesis and Xenobiotic Responses

(2010) Y. Zhai et al.   MOLECULAR PHARMACOLOGY

Nuclear Receptor CAR Represses TNFα-Induced Cell Death by Interacting with the Anti-Apoptotic GADD45B

(2010) Yukio Yamamoto et al.   PLoS One

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

(2010) Jillian Ross et al.   TOXICOLOGICAL SCIENCES

The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice

(2009) Wayne A. Fritz et al.   BIOCHEMICAL PHARMACOLOGY

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

(2009) Jennifer C. Schroeder et al.   BIOCHEMISTRY

Peroxisome proliferator-activated receptor γ-dependent activity of indole ring-substituted 1,1-bis(3′-indolyl)-1-(p-biphenyl)methanes in cancer cells

(2009) Jingjing Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Activation of the aryl hydrocarbon receptor pathway enhances cancer cell invasion by upregulating the MMP expression and is associated with poor prognosis in upper urinary tract urothelial cancer

(2009) M. Ishida et al.   CARCINOGENESIS

Breaking old paradigms: Th17 cells in autoimmune arthritis

(2009) Ariana Peck et al.   CLINICAL IMMUNOLOGY

Drug Uptake Systems in Liver and Kidney: A Historic Perspective

(2009) B Hagenbuch   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity

(2009) Jie Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)

(2009) Shingo Mutoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ah receptor represses acute-phase response gene expression without binding to its cognate response element

(2009) Rushang D Patel et al.   LABORATORY INVESTIGATION

The Dioxin Receptor Regulates the Constitutive Expression of the Vav3 Proto-Oncogene and Modulates Cell Shape and Adhesion

(2009) Jose M. Carvajal-Gonzalez et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of peroxisome proliferator-activated receptor-β/δ by the APC/β-CATENIN pathway and nonsteroidal antiinflammatory drugs

(2009) Jennifer E. Foreman et al.   MOLECULAR CARCINOGENESIS

Di(2-ethylhexyl) phthalate Is a Highly Potent Agonist for the Human Constitutive Androstane Receptor Splice Variant CAR2

(2009) J. G. DeKeyser et al.   MOLECULAR PHARMACOLOGY

15-Hydroxyeicosatetraenoic Acid Is a Preferential Peroxisome Proliferator-Activated Receptor  /  Agonist

(2009) S. Naruhn et al.   MOLECULAR PHARMACOLOGY

Evidence for Ligand-Mediated Selective Modulation of Aryl Hydrocarbon Receptor Activity

(2009) I. A. Murray et al.   MOLECULAR PHARMACOLOGY

Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic Mice

(2009) C. A. Flaveny et al.   MOLECULAR PHARMACOLOGY

Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity

(2009) L -C Bui et al.   ONCOGENE

Fascin-1 Promoter Activity Is Regulated by CREB and the Aryl Hydrocarbon Receptor in Human Carcinoma Cells

(2009) Yosuke Hashimoto et al.   PLoS One

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

(2009) B. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PXR and CAR in energy metabolism

(2009) Taira Wada et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PPARβ/δ agonist stimulates human lung carcinoma cell growth through inhibition of PTEN expression: the involvement of PI3K and NF-κB signals

(2008) ShouWei Han et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Quantitative expression patterns of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) protein in mice

(2008) Elizabeth E. Girroir et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor

(2008) Christoph Köhle et al.   BIOCHEMICAL PHARMACOLOGY

Serum amyloid A: An acute-phase protein involved in tumour pathogenesis

(2008) E. Malle et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterization of the Antiallergic Drugs 3-[2-(2-Phenylethyl) benzoimidazole-4-yl]-3-hydroxypropanoic Acid and Ethyl 3-Hydroxy-3-[2-(2-phenylethyl)benzoimidazol-4-yl]propanoate as Full Aryl Hydrocarbon Receptor Agonists

(2008) José Luis Morales et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Role of peroxisome-proliferator-activated receptor β/δ (PPARβ/δ) in gastrointestinal tract function and disease

(2008) Jeffrey M. Peters et al.   CLINICAL SCIENCE

The Roles of Nuclear Receptors CAR and PXR in Hepatic Energy Metabolism

(2008) Yoshihiro Konno et al.   Drug Metabolism and Pharmacokinetics

PPAR-β/δ agonists for Type 2 diabetes and dyslipidemia: an adopted orphan still looking for a home

(2008) Andrew N Billin   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Loss of the Aryl Hydrocarbon Receptor Induces Hypoxemia, Endothelin-1, and Systemic Hypertension at Modest Altitude

(2008) Amie K. Lund et al.   HYPERTENSION

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response

(2008) Nico Scheer et al.   JOURNAL OF CLINICAL INVESTIGATION

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

(2008) Marc Veldhoen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

(2008) A. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase

(2008) A. J. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPAR alpha, more than PPAR delta, Mediates the Hepatic and Skeletal Muscle Alterations Induced by the PPAR Agonist GW0742

(2008) Brenda Faiola et al.   TOXICOLOGICAL SCIENCES

Abnormal Liver Development and Resistance to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Toxicity in Mice Carrying a Mutation in the DNA-Binding Domain of the Aryl Hydrocarbon Receptor

(2008) Maureen K. Bunger et al.   TOXICOLOGICAL SCIENCES

Ligand Activation of Peroxisome Proliferator–Activated Receptor β/δ (PPARβ/δ) Attenuates Carbon Tetrachloride Hepatotoxicity by Downregulating Proinflammatory Gene Expression

(2008) Weiwei Shan et al.   TOXICOLOGICAL SCIENCES

Xenoreceptors CAR and PXR Activation and Consequences on Lipid Metabolism, Glucose Homeostasis, and Inflammatory Response

(2007) Amélie Moreau et al.   MOLECULAR PHARMACEUTICS