Amelioration of Mitochondrial Quality Control and Proteostasis by Natural Compounds in Parkinson’s Disease Models

The Effect of Fucoidan on Cellular Oxidative Stress and the CatD-Bax Signaling Axis in MN9D Cells Damaged by 1-Methyl-4-Phenypyridinium

(2019) Zhigang Liang et al.   Frontiers in Aging Neuroscience

Chlorogenic Acid Exerts Beneficial Effects in 6-Hydroxydopamine-Induced Neurotoxicity by Inhibition of Endoplasmic Reticulum Stress

(2019) Shihai Shan et al.   MEDICAL SCIENCE MONITOR

β-Asarone Regulates ER Stress and Autophagy Via Inhibition of the PERK/CHOP/Bcl-2/Beclin-1 Pathway in 6-OHDA-Induced Parkinsonian Rats

(2019) Baile Ning et al.   NEUROCHEMICAL RESEARCH

The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1’s association with the mitochondrial protein TOM20

(2019) Conggang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress

(2019) Hyojung Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sesamin and sesamol attenuate H2O2 -induced oxidative stress on human neuronal cells via the SIRT1-SIRT3-FOXO3a signaling pathway

(2019) Waralee Ruankham et al.   NUTRITIONAL NEUROSCIENCE

Salidroside Protects Dopaminergic Neurons by Preserving Complex I Activity via DJ-1/Nrf2-Mediated Antioxidant Pathway

(2019) Ruru Li et al.   Parkinsons Disease

Auraptene Mitigates Parkinson’s Disease-Like Behavior by Protecting Inhibition of Mitochondrial Respiration and Scavenging Reactive Oxygen Species

(2019) Yunseon Jang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prophylactic neuroprotective propensity of Crocin, a carotenoid against rotenone induced neurotoxicity in mice: behavioural and biochemical evidence

(2019) Sriranjini Venkata Rao et al.   METABOLIC BRAIN DISEASE

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy

(2019) Jia-Zhen Wu et al.   Translational Neurodegeneration

Fucoidan Suppresses Mitochondrial Dysfunction and Cell Death against 1-Methyl-4-Phenylpyridinum-Induced Neuronal Cytotoxicity via Regulation of PGC-1α Expression

(2019) Yong-Seok Han et al.   Marine Drugs

Neuroprotective Effects of Ginseng Phytochemicals: Recent Perspectives

(2019) Xing Huang et al.   MOLECULES

Thymoquinone prevents neurodegeneration against MPTP in vivo and modulates α-synuclein aggregation in vitro

(2019) Mustafa T. Ardah et al.   NEUROCHEMISTRY INTERNATIONAL

Neurotoxin-Induced Animal Models of Parkinson Disease: Pathogenic Mechanism and Assessment

(2018) Xian-Si Zeng et al.   ASN Neuro

Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives

(2018) Jin-Sung Park et al.   Current Neurology and Neuroscience Reports

Botanicals and phytochemicals active on cognitive decline: The clinical evidence

(2018) Arrigo F.G. Cicero et al.   PHARMACOLOGICAL RESEARCH

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease

(2018) Jessika C. Bridi et al.   Frontiers in Neuroscience

Salidroside Promotes the Pathological α-Synuclein Clearance Through Ubiquitin-Proteasome System in SH-SY5Y Cells

(2018) Tao Li et al.   Frontiers in Pharmacology

Hormetic approaches to the treatment of Parkinson's disease: Perspectives and possibilities

(2018) Vittorio Calabrese et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein

(2018) Sai Zhang et al.   Neural Regeneration Research

Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson’s Disease

(2018) Li Zhang et al.   Aging and Disease

Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson’s Disease Models

(2018) Ekaterina Yurchenko et al.   Marine Drugs

Rosmarinic acid protects against MPTP-induced toxicity and inhibits iron-induced α-synuclein aggregation

(2018) Le Qu et al.   NEUROPHARMACOLOGY

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

(2018) Tae-In Kam et al.   SCIENCE

Troxerutin exerts neuroprotection in 6-hydroxydopamine lesion rat model of Parkinson’s disease: Possible involvement of PI3K/ERβ signaling

(2017) Tourandokht Baluchnejadmojarad et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ginsenosides Rd and Re co-treatments improve rotenone-induced oxidative stress and mitochondrial impairment in SH-SY5Y neuroblastoma cells

(2017) E. González-Burgos et al.   FOOD AND CHEMICAL TOXICOLOGY

Astragaloside IV attenuates the H2O2-induced apoptosis of neuronal cells by inhibiting α-synuclein expression via the p38 MAPK pathway

(2017) Xiang Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Effects of saffron and its constituents, crocin-1, crocin-2, and crocetin on α-synuclein fibrils

(2017) Eiji Inoue et al.   Journal of Natural Medicines

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease

(2017) Muhammet Ay et al.   JOURNAL OF NEUROCHEMISTRY

Levodopa in Parkinson’s Disease: A Review of Population Pharmacokinetics/Pharmacodynamics Analysis

(2017) Amélie Marsot et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Potential molecular mechanisms mediating the protective effects of tetrahydroxystilbene glucoside on MPP+-induced PC12 cell apoptosis

(2017) Lingling Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease

(2017) Alice Biosa et al.   NEUROBIOLOGY OF DISEASE

Isorhynchophylline Attenuates MPP+-Induced Apoptosis Through Endoplasmic Reticulum Stress- and Mitochondria-Dependent Pathways in PC12 Cells: Involvement of Antioxidant Activity

(2017) Xiao-Ming Li et al.   NEUROMOLECULAR MEDICINE

Thymoquinone exerts neuroprotective effect in animal model of Parkinson’s disease

(2017) Seyedeh Shohreh Ebrahimi et al.   TOXICOLOGY LETTERS

Inhibition of α-Synuclein contributes to the ameliorative effects of dietary flavonoids luteolin on arsenite-induced apoptotic cell death in the dopaminergic PC12 cells

(2017) Yi Wu et al.   TOXICOLOGY MECHANISMS AND METHODS

Astragaloside IV rescues MPP+-induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A

(2017) Yue Liu et al.   Experimental and Therapeutic Medicine

Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models

(2017) Hyojung Kim et al.   Oncotarget

Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways

(2017) Chao Zhang et al.   Scientific Reports

Inhibition of α-Synuclein contributes to the ameliorative effects of dietary flavonoids luteolin on arsenite-induced apoptotic cell death in the dopaminergic PC12 cells

(2017) Yi Wu et al.   TOXICOLOGY MECHANISMS AND METHODS

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?

(2017) Dominika Truban et al.   Journal of Parkinsons Disease

Oxidative stress and cellular pathologies in Parkinson’s disease

(2017) Lesly Puspita et al.   Molecular Brain

Neurochemical and Behavior Deficits in Rats with Iron and Rotenone Co-treatment: Role of Redox Imbalance and Neuroprotection by Biochanin A

(2017) Lijia Yu et al.   Frontiers in Neuroscience

Curcumin affords neuroprotection and inhibits α-synuclein aggregation in lipopolysaccharide-induced Parkinson’s disease model

(2017) Neha Sharma et al.   INFLAMMOPHARMACOLOGY

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson’s disease model

(2017) Sangwoo Ham et al.   Scientific Reports

Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity

(2016) Zhao-xiang Ren et al.   ACTA PHARMACOLOGICA SINICA

Cordycepin protects PC12 cells against 6-hydroxydopamine induced neurotoxicity via its antioxidant properties

(2016) Opeyemi J. Olatunji et al.   BIOMEDICINE & PHARMACOTHERAPY

Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone

(2016) Hayate Javed et al.   BMC NEUROSCIENCE

Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson's disease

(2016) Hanaa Hibishy Gaballah et al.   CHEMICO-BIOLOGICAL INTERACTIONS

DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7

(2016) M. Di Nottia et al.   CLINICAL GENETICS

Structure–activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron

(2016) Jing Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Ameliorative Effect of Quercetin on Neurochemical and Behavioral Deficits in Rotenone Rat Model of Parkinson's Disease: Modulating Autophagy (Quercetin on Experimental Parkinson's Disease)

(2016) Hemat E. El-Horany et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced Parkinsonian mouse model

(2016) Sachchida Nand Rai et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Neuroprotective Effect of the Marine-Derived Compound 11-Dehydrosinulariolide through DJ-1-Related Pathway in In Vitro and In Vivo Models of Parkinson’s Disease

(2016) Chien-Wei Feng et al.   Marine Drugs

Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson’s Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions

(2016) Haidy E. Michel et al.   MOLECULAR NEUROBIOLOGY

Triptolide Promotes the Clearance of α-Synuclein by Enhancing Autophagy in Neuronal Cells

(2016) Guanzheng Hu et al.   MOLECULAR NEUROBIOLOGY

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The status of Nrf2-based therapeutics: current perspectives and future prospects

(2016) IrinaG Gazaryan et al.   Neural Regeneration Research

Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity

(2016) Kaige Peng et al.   Oxidative Medicine and Cellular Longevity

Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra

(2016) Yang Heng et al.   TOXICOLOGY LETTERS

Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson’s disease model induced by MPTP

(2016) Emily Filichia et al.   Scientific Reports

Antioxidants inhibit neuronal toxicity in Parkinson's disease-linked LRRK2

(2016) Dario C. Angeles et al.   Annals of Clinical and Translational Neurology

Conophylline Protects Cells in Cellular Models of Neurodegenerative Diseases by Inducing Mammalian Target of Rapamycin (mTOR)-independent Autophagy

(2015) Yukiko Sasazawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity

(2015) Ryoichi Takahashi et al.   JOURNAL OF NEUROCHEMISTRY

Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson’s disease

(2015) Yupin Chen et al.   Molecular Neurodegeneration

Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils

(2015) Mustafa T. Ardah et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective Effects of Tanshinone I Against 6-OHDA-Induced Oxidative Stress in Cellular and Mouse Model of Parkinson’s Disease Through Upregulating Nrf2

(2015) Xu Jing et al.   NEUROCHEMICAL RESEARCH

Bioavailability of dietary polyphenols: Factors contributing to their clinical application in CNS diseases

(2015) M.D. Pandareesh et al.   NEUROCHEMISTRY INTERNATIONAL

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Tea polyphenols alleviate motor impairments, dopaminergic neuronal injury, and cerebral α-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys

(2015) M. Chen et al.   NEUROSCIENCE

Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway

(2015) X.S. Zhang et al.   NEUROSCIENCE

Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCδ/NF-κB pathway

(2015) H. Dong et al.   NEUROSCIENCE

Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases

(2015) Ronald Melki   Journal of Parkinsons Disease

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

(2014) Judith Eschbach et al.   ANNALS OF NEUROLOGY

p53 and mitochondrial function in neurons

(2014) David B. Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protective Effect of Chinonin in MPTP-Induced C57BL/6 Mouse Model of Parkinson’s Disease

(2014) Guoshuai Feng et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Limiting the power of p53 through the ubiquitin proteasome pathway

(2014) Vinod Pant et al.   GENES & DEVELOPMENT

Quercetin Glycosides Induced Neuroprotection by Changes in the Gene Expression in a Cellular Model of Parkinson’s Disease

(2014) Kasthuri Bai Magalingam et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Corynoxine, a Natural Autophagy Enhancer, Promotes the Clearance of Alpha-Synuclein via Akt/mTOR Pathway

(2014) Lei-Lei Chen et al.   Journal of Neuroimmune Pharmacology

Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease

(2014) Anke A. Dijkstra et al.   MOVEMENT DISORDERS

Gastrodin protects against MPP+-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK/Nrf2 pathway in human dopaminergic cells

(2014) Genling Jiang et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice

(2014) Sachin P. Patil et al.   NEUROPHARMACOLOGY

Mitochondrial Fission and Fusion in Human Diseases

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice

(2014) Michelle S. Antunes et al.   NUTRITION

Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo

(2014) Phillip M. Rappold et al.   Nature Communications

Environmental Toxins and Parkinson's Disease

(2013) Samuel M. Goldman   Annual Review of Pharmacology and Toxicology

Amurensin G induces autophagy and attenuates cellular toxicities in a rotenone model of Parkinson’s disease

(2013) Hyun-Wook Ryu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols

(2013) Angelique Camilleri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Inhibition of formation of α-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease

(2013) Cristiana Faria et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Puerarin attenuates neuronal degeneration in the substantia nigra of 6-OHDA-lesioned rats through regulating BDNF expression and activating the Nrf2/ARE signaling pathway

(2013) Rong Li et al.   BRAIN RESEARCH

P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells

(2013) Xiang-Bao Meng et al.   Evidence-based Complementary and Alternative Medicine

Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells

(2013) An-Guo Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective Effect of Gypenosides against Oxidative Injury in the Substantia Nigra of a Mouse Model of Parkinson's Disease

(2013) P Wang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

The current and projected economic burden of Parkinson's disease in the United States

(2013) Stacey L. Kowal et al.   MOVEMENT DISORDERS

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

(2013) Yunjong Lee et al.   NATURE NEUROSCIENCE

Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy

(2013) Yong-Ning Deng et al.   NEUROCHEMISTRY INTERNATIONAL

Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway

(2013) Haiyan Lou et al.   NEUROPHARMACOLOGY

Sesamol and naringenin reverse the effect of rotenone-induced PD rat model

(2013) M. Sonia Angeline et al.   NEUROSCIENCE

Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish

(2013) Cheong-Meng Chong et al.   NEUROSCIENCE LETTERS

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy

(2012) Jia-Hong Lu et al.   Autophagy

Salvianolic acid A protects human SH-SY5Y neuroblastoma cells against H2O2-induced injury by increasing stress tolerance ability

(2012) Heng-ai Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Isoliquiritigenin Isolated from LicoriceGlycyrrhiza uralensisPrevents 6-Hydroxydopamine-Induced Apoptosis in Dopaminergic Neurons

(2012) Cheol Kyu HWANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway

(2012) Qinyong Ye et al.   BMC Complementary and Alternative Medicine

Astaxanthin protects against MPP+-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis

(2012) Qinyong Ye et al.   BMC NEUROSCIENCE

Baicalein Protects against 6-OHDA-Induced Neurotoxicity through Activation of Keap1/Nrf2/HO-1 and Involving PKCα and PI3K/AKT Signaling Pathways

(2012) Zaijun Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mitochondrial redox signalling at a glance

(2012) Yvonne Collins et al.   JOURNAL OF CELL SCIENCE

Cytoprotective effect of chlorogenic acid against α-synuclein-related toxicity in catecholaminergic PC12 cells

(2012) Mari Teraoka et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Therapeutic Effects of Rapamycin on MPTP-Induced Parkinsonism in Mice

(2012) Kangyong Liu et al.   NEUROCHEMICAL RESEARCH

Overexpression of Parkin Ameliorates Dopaminergic Neurodegeneration Induced by 1- Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice

(2012) Minjuan Bian et al.   PLoS One

Magnolol Protects against MPTP/MPP+-Induced Toxicity via Inhibition of Oxidative Stress inIn VivoandIn VitroModels of Parkinson’s Disease

(2012) Akiko Muroyama et al.   Parkinsons Disease

Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease

(2011) Shen Li et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

ASICs mediate the modulatory effect by paeoniflorin on alpha-synuclein autophagic degradation

(2011) Xue Sun et al.   BRAIN RESEARCH

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

(2011) Giuseppa Mudò et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of  -Synuclein

(2011) D. Ebrahimi-Fakhari et al.   JOURNAL OF NEUROSCIENCE

The Parkinson's disease market

(2011) Trung Huynh   NATURE REVIEWS DRUG DISCOVERY

Myricetin attenuated MPP+-induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK activation in MES23.5 cells

(2011) Kai Zhang et al.   NEUROPHARMACOLOGY

Asiaticoside: Attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax

(2011) Chang-Liang Xu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage

(2011) H. C. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo

(2010) Zhen-tao Zhang et al.   ACTA PHARMACOLOGICA SINICA

Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro

(2010) Dae-Hee Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

Redox Reactions Induced by Nitrosative Stress Mediate Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases

(2010) Zezong Gu et al.   MOLECULAR NEUROBIOLOGY

The role of parkin in familial and sporadic Parkinson's disease

(2010) Ted M. Dawson et al.   MOVEMENT DISORDERS

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease

(2010) Giuseppe Filomeni et al.   NEUROBIOLOGY OF AGING

Chrysotoxine, a novel bibenzyl compound, inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via mitochondria protection and NF-κB modulation

(2010) Ju-Xian Song et al.   NEUROCHEMISTRY INTERNATIONAL

dl-3-n-Butylphthalide prevents oxidative damage and reduces mitochondrial dysfunction in an MPP+-induced cellular model of Parkinson's disease

(2010) Jin-zhong Huang et al.   NEUROSCIENCE LETTERS

Protective, Antioxidative and Antiapoptotic Effects of 2-Methoxy-6-Acetyl-7-Methyljuglone fromPolygonum cuspidatumin PC12 Cells

(2010) Ying Li et al.   PLANTA MEDICA

PGC-1 , A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

(2010) B. Zheng et al.   Science Translational Medicine

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease

(2009) Cristine Alves da Costa et al.   NATURE CELL BIOLOGY

Curcumin inhibits aggregation of α-synuclein

(2008) Neeraj Pandey et al.   ACTA NEUROPATHOLOGICA

Oxidative and nitrosative stress in Parkinson's disease

(2008) Anthony H.K. Tsang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Mitochondrial fragmentation in neurodegeneration

(2008) Andrew B. Knott et al.   NATURE REVIEWS NEUROSCIENCE

Involvement of ubiquitin proteasome system in protective mechanisms of Puerarin to MPP+-elicited apoptosis

(2008) Yue-Fa Cheng et al.   NEUROSCIENCE RESEARCH

Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents 6-hydroxydopamine induced apoptosis in SH-SY5Y cells

(2007) Lin-Lin Tian et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY