P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells

Decursin Isolated fromAngelica gigasNakai Rescues PC12 Cells from Amyloidβ-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK

(2013) Li Li et al.   Evidence-based Complementary and Alternative Medicine

Gastrodin Protects Apoptotic Dopaminergic Neurons in a Toxin-Induced Parkinson’s Disease Model

(2013) Hemant Kumar et al.   Evidence-based Complementary and Alternative Medicine

Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice

(2013) Eun Jung Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Target- and Mechanism-Based Therapeutics for Neurodegenerative Diseases: Strength in Numbers

(2013) Paul C. Trippier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arylpiperazine-mediated activation of Akt protects SH-SY5Y neuroblastoma cells from 6-hydroxydopamine-induced apoptotic and autophagic death

(2013) Gordana Tovilovic et al.   NEUROPHARMACOLOGY

Protective effect of creatine against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells: Involvement of intracellular signaling pathways

(2013) M.P. Cunha et al.   NEUROSCIENCE

Molecular Events Underlying Parkinson’s Disease – An Interwoven Tapestry

(2013) Kah-Leong Lim et al.   Frontiers in Neurology

Role of Oxidative Stress in Parkinson's Disease

(2013) Onyou Hwang   Experimental Neurobiology

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

(2012) Michael H. Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rescue of PINK1 Protein Null-specific Mitochondrial Complex IV Deficits by Ginsenoside Re Activation of Nitric Oxide Signaling

(2012) Kyung-Hee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blocking c-Jun N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-Hydroxydopamine-induced Toxicityin Vitroandin Vivo

(2012) Jeremy W. Chambers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt/Nrf2 Activated Upregulation of Heme Oxygenase-1 Involves in the Role of Rg1 Against Ferrous Iron-Induced Neurotoxicity in SK-N-SH Cells

(2012) Xixun Du et al.   NEUROTOXICITY RESEARCH

RETRACTED: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors

(2012) Julio C. Tobón-Velasco et al.   TOXICOLOGY

Oxidative stress suppression by luteolin-induced heme oxygenase-1 expression

(2012) Gui-bo Sun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Characterization of ERK Docking Domain Inhibitors that Induce Apoptosis by Targeting Rsk-1 and Caspase-9

(2011) Sarice R Boston et al.   BMC CANCER

Cognitive-Enhancing Effect of Quercetin in a Rat Model of Parkinson's Disease Induced by 6-Hydroxydopamine

(2011) Napatr Sriraksa et al.   Evidence-based Complementary and Alternative Medicine

Lonicera japonica THUNB. protects 6-hydroxydopamine-induced neurotoxicity by inhibiting activation of MAPKs, PI3K/Akt, and NF-κB in SH-SY5Y cells

(2011) Seung-Hwan Kwon et al.   FOOD AND CHEMICAL TOXICOLOGY

ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation

(2011) Xin Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Treatment of a Human Papillomavirus Type 31b-Positive Cell Line with Benzo[a]Pyrene Increases Viral Titer through Activation of the Erk1/2 Signaling Pathway

(2011) B. S. Bowser et al.   JOURNAL OF VIROLOGY

Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling

(2011) Jindong Xu et al.   NEUROBIOLOGY OF AGING

Hsp27 Promotes Insulin-Like Growth Factor-I Survival Signaling in Prostate Cancer via p90Rsk-Dependent Phosphorylation and Inactivation of BAD

(2010) A. Zoubeidi et al.   CANCER RESEARCH

Protective effect of panaxatriol saponins extracted from Panax notoginseng against MPTP-induced neurotoxicity in vivo

(2010) Fu-Cheng Luo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF-I receptor signalling pathway

(2009) Li Xu et al.   BRITISH JOURNAL OF PHARMACOLOGY

San-Huang-Xie-Xin-Tang Protects against Activated Microglia- and 6-OHDA-Induced Toxicity in Neuronal SH-SY5Y Cells

(2009) Yu-Tzu Shih et al.   Evidence-based Complementary and Alternative Medicine

15-Deoxy-Δ12,14-prostaglandin J2 rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: Potential roles of Akt and ERK1/2

(2008) Ji-Woo Kim et al.   BIOCHEMICAL PHARMACOLOGY

The roles of MAPKs in disease

(2008) Michael C Lawrence et al.   CELL RESEARCH