Acute manganese treatment restores defective autophagic cargo loading in Huntington’s disease cell lines

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line

(2018) Miles R. Bryan et al.   NEUROTOXICOLOGY

Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal neurotoxicity

(2018) Dilshan S. Harischandra et al.   NEUROTOXICOLOGY

Autophagy plays a protective role in Mn-induced toxicity in PC12 cells

(2018) Qian Zhou et al.   TOXICOLOGY

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

(2018) Dagmar E. Ehrnhoefer et al.   Acta Neuropathologica Communications

PI3K/Akt signaling pathway and Hsp70 activate in hippocampus of rats with chronic manganese sulfate exposure

(2018) Hong Cheng et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation

(2018) Karolina Pircs et al.   Cell Reports

The role S-nitrosylation in manganese-induced autophagy dysregulation in SH-SY5Y cells

(2017) Zhuo Ma et al.   ENVIRONMENTAL TOXICOLOGY

A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation

(2017) Amanda L. Neisch et al.   JOURNAL OF CELL BIOLOGY

Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells

(2017) Yu-Ting Kang et al.   Oncotarget

Effects of Cobalt Chloride, a Hypoxia-Mimetic Agent, on Autophagy and Atrophy in Skeletal C2C12 Myotubes

(2017) Rui Chen et al.   Biomed Research International

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Manganese-Stimulated Kisspeptin Is Mediated by the IGF-1/Akt/Mammalian Target of Rapamycin Pathway in the Prepubertal Female Rat

(2016) Vinod K. Srivastava et al.   ENDOCRINOLOGY

Autophagy in Neurodegenerative Diseases and Metal Neurotoxicity

(2016) Ziyan Zhang et al.   NEUROCHEMICAL RESEARCH

Lutein Attenuates Both Apoptosis and Autophagy upon Cobalt (II) Chloride-Induced Hypoxia in Rat Műller Cells

(2016) Frederic K. C. Fung et al.   PLoS One

Iron mitigates DMT1-mediated manganese cytotoxicity via the ASK1-JNK signaling axis: Implications of iron supplementation for manganese toxicity

(2016) Yee Kit Tai et al.   Scientific Reports

Manganese Is Essential for Neuronal Health

(2015) Kyle J. Horning et al.   Annual Review of Nutrition

The autophagic- lysosomal pathway determines the fate of glial cells under manganese- induced oxidative stress conditions

(2015) RM Gorojod et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Huntington's disease: An update of therapeutic strategies

(2015) Ashok Kumar et al.   GENE

Neferine Attenuates the Protein Level and Toxicity of Mutant Huntingtin in PC-12 Cells via Induction of Autophagy

(2015) Vincent Wong et al.   MOLECULES

Huntingtin facilitates selective autophagy

(2015) Amir Gelman et al.   NATURE CELL BIOLOGY

Huntingtin functions as a scaffold for selective macroautophagy

(2015) Yan-Ning Rui et al.   NATURE CELL BIOLOGY

Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes

(2015) John H. Lee et al.   NEURON

NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor

(2015) Lan Yu et al.   Oncotarget

Does bafilomycin A1block the fusion of autophagosomes with lysosomes?

(2014) Daniel J. Klionsky et al.   Autophagy

Prepubertal exposure to elevated manganese results in estradiol regulated mammary gland ductal differentiation and hyperplasia in female rats

(2014) Robert K Dearth et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease

(2014) Andrew M. Tidball et al.   HUMAN MOLECULAR GENETICS

Activation of MAPK and FoxO by Manganese (Mn) in Rat Neonatal Primary Astrocyte Cultures

(2014) Vernat Exil et al.   PLoS One

Potential function for the Huntingtin protein as a scaffold for selective autophagy

(2014) Joseph Ochaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhes, a Striatal-selective Protein Implicated in Huntington Disease, Binds Beclin-1 and Activates Autophagy

(2013) Robert G. Mealer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Autophagy Dysregulation in Manganese-Induced Dopaminergic Neurodegeneration

(2013) Jianbin Zhang et al.   NEUROTOXICITY RESEARCH

Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis

(2013) Katja M. Kanninen et al.   PLoS One

Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1–PP2A protein complex

(2013) Sybille Krauß et al.   Nature Communications

Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and jnk activation

(2012) Cristina Trejo-Solís et al.   BMC CANCER

The role of ALFY in selective autophagy

(2012) P Isakson et al.   CELL DEATH AND DIFFERENTIATION

Disease-Toxicant Interactions in Manganese Exposed Huntington Disease Mice: Early Changes in Striatal Neuron Morphology and Dopamine Metabolism

(2012) Jennifer L. Madison et al.   PLoS One

In Vivo Manganese Exposure Modulates Erk, Akt and Darpp-32 in the Striatum of Developing Rats, and Impairs Their Motor Function

(2012) Fabiano M. Cordova et al.   PLoS One

Protein aggregates in Huntington's disease

(2011) Montserrat Arrasate et al.   EXPERIMENTAL NEUROLOGY

Nrf2/HO-1 pathway activation by manganese is associated with reactive oxygen species and ubiquitin-proteasome pathway, not MAPKs signaling

(2011) Huangyuan Li et al.   JOURNAL OF APPLIED TOXICOLOGY

Novel high-throughput assay to assess cellular manganese levels in a striatal cell line model of Huntington's disease confirms a deficit in manganese accumulation

(2011) Gunnar F. Kwakye et al.   NEUROTOXICOLOGY

Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells

(2011) Hilary Afeseh Ngwa et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Neurodegenerative processes in Huntington's disease

(2011) D Bano et al.   Cell Death & Disease

Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy

(2010) Weiliang Fan et al.   Autophagy

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy

(2010) Maria Filimonenko et al.   MOLECULAR CELL

The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease

(2010) Jonathan H Fox et al.   Molecular Neurodegeneration

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Postnatal manganese exposure alters the expression of D2L and D2S receptor isoforms: Relationship to PKA activity and Akt levels

(2010) Sanders A. Mcdougall et al.   SYNAPSE

Altered Manganese Homeostasis and Manganese Toxicity in a Huntington's Disease Striatal Cell Model Are Not Explained by Defects in the Iron Transport System

(2010) B. Blairanne Williams et al.   TOXICOLOGICAL SCIENCES

Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes

(2010) Sook-Jeong Lee et al.   Molecular Brain

Specific Activation of mTORC1 by Rheb G-proteinin VitroInvolves Enhanced Recruitment of Its Substrate Protein

(2009) Tatsuhiro Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disease-toxicant screen reveals a neuroprotective interaction between Huntington’s disease and manganese exposure

(2009) B. Blairanne Williams et al.   JOURNAL OF NEUROCHEMISTRY

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases

(2008) Ray Truant et al.   FEBS Journal

Huntington’s disease: degradation of mutant huntingtin by autophagy

(2008) Sovan Sarkar et al.   FEBS Journal

Rapamycin Inhibits Polyglutamine Aggregation Independently of Autophagy by Reducing Protein Synthesis

(2008) M. A. King et al.   MOLECULAR PHARMACOLOGY

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology