Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis

Mutation of the parkinsonism gene ATP13A2 causes neuronal ceroid-lipofuscinosis

(2012) Jose Bras et al.   HUMAN MOLECULAR GENETICS

Effect of zinc supplementation on type 2 diabetes parameters and liver metallothionein expressions in Wistar rats

(2012) Xue Wang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Mutations in the Gene DNAJC5 Cause Autosomal Dominant Kufs Disease in a Proportion of Cases: Study of the Parry Family and 8 Other Families

(2012) Milen Velinov et al.   PLoS One

Common Pathogenic Effects of Missense Mutations in the P-Type ATPase ATP13A2 (PARK9) Associated with Early-Onset Parkinsonism

(2012) Agata Podhajska et al.   PLoS One

Zinc in Neurotransmission

(2011) Katalin Tóth   Annual Review of Nutrition

Altered Heavy Metals and Transketolase Found in Autistic Spectrum Disorder

(2011) Mark E. Obrenovich et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Intracellular zinc release-activated ERK-dependent GSK-3β–p53 and Noxa–Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury

(2011) C-L Lin et al.   CELL DEATH AND DIFFERENTIATION

Childhood disorders of neurodegeneration with brain iron accumulation (NBIA)

(2011) MANJU A KURIAN et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell death

(2011) Janet Ugolino et al.   HUMAN MOLECULAR GENETICS

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

(2011) David Ramonet et al.   HUMAN MOLECULAR GENETICS

Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses

(2011) Maria Kousi et al.   HUMAN MUTATION

The Neurophysiology and Pathology of Brain Zinc

(2011) S. L. Sensi et al.   JOURNAL OF NEUROSCIENCE

Role of manganese in neurodegenerative diseases

(2011) Aaron B. Bowman et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

A truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in Tibetan terriers

(2011) Fabiana H.G. Farias et al.   NEUROBIOLOGY OF DISEASE

Zinc and the ERK Kinases in the Developing Brain

(2011) J. R. Nuttall et al.   NEUROTOXICITY RESEARCH

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

(2011) Paul A. Adlard et al.   PLoS One

A One Base Pair Deletion in the Canine ATP13A2 Gene Causes Exon Skipping and Late-Onset Neuronal Ceroid Lipofuscinosis in the Tibetan Terrier

(2011) Anne Wöhlke et al.   PLoS Genetics

Determination of Zinc, Copper, Iron, and Manganese in Different Regions of Lamb Brain

(2010) Sezgin Bakirdere et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

The specific loss of GnRH-positive neurons from the hypothalamus of sheep with CLN6 neuronal ceroid lipofuscinosis occurs without glial activation and has only minor effects on reproduction

(2010) Graham W. Kay et al.   NEUROBIOLOGY OF DISEASE

Biological metals and Alzheimer's disease: Implications for therapeutics and diagnostics

(2010) James A. Duce et al.   PROGRESS IN NEUROBIOLOGY

Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes

(2010) Sook-Jeong Lee et al.   Molecular Brain

The role of zinc transporters in cadmium and manganese transport in mammalian cells

(2009) Seiichiro Himeno et al.   BIOCHIMIE

Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease

(2009) C. Kielar et al.   HUMAN MOLECULAR GENETICS

Protein product ofCLN6gene responsible for variant late-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2

(2009) Jared W. Benedict et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Metal Ion Physiopathology in Neurodegenerative Disorders

(2009) Silvia Bolognin et al.   NEUROMOLECULAR MEDICINE

Psoroptic mange infestation increases oxidative stress and decreases antioxidant status in sheep

(2009) U. Dimri et al.   VETERINARY PARASITOLOGY

Novel interactions of CLN3 protein link Batten disease to dysregulation of fodrin–Na+, K+ ATPase complex

(2008) Kristiina Uusi-Rauva et al.   EXPERIMENTAL CELL RESEARCH

Location and connectivity determine GABAergic interneuron survival in the brains of South Hampshire sheep with CLN6 neuronal ceroid lipofuscinosis

(2008) Manfred J. Oswald et al.   NEUROBIOLOGY OF DISEASE

A new large animal model of CLN5 neuronal ceroid lipofuscinosis in Borderdale sheep is caused by a nucleotide substitution at a consensus splice site (c.571+1G>>>A) leading to excision of exon 3

(2007) Tony Frugier et al.   NEUROBIOLOGY OF DISEASE