Using Xenopus oocytes in neurological disease drug discovery

Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6GABAA receptors

(2019) D. Vasović et al.   EUROPEAN JOURNAL OF PAIN

Present Algorithms and Future Treatments for Alzheimer’s Disease

(2019) George T. Grossberg et al.   JOURNAL OF ALZHEIMERS DISEASE

A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy

(2018) Talia A. Atkin et al.   EPILEPSIA

Opioid receptors: drivers to addiction?

(2018) Emmanuel Darcq et al.   NATURE REVIEWS NEUROSCIENCE

A novel action of lacosamide on GABA A currents sets the ground for a synergic interaction with levetiracetam in treatment of epilepsy

(2018) Gabriele Ruffolo et al.   NEUROBIOLOGY OF DISEASE

Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists

(2018) Jinpeng Yu et al.   NEUROPHARMACOLOGY

Genetic variation in P2RX7 and pain tolerance

(2018) Oleg Kambur et al.   PAIN

The Peptide PnPP-19, a Spider Toxin Derivative, Activates μ-Opioid Receptors and Modulates Calcium Channels

(2018) Ana Freitas et al.   Toxins

Tropisetron sensitizes α7 containing nicotinic receptors to low levels of acetylcholine in vitro and improves memory-related task performance in young and aged animals

(2017) Patrick M. Callahan et al.   NEUROPHARMACOLOGY

Evaluation of microtransplantation of rat brain neurolemma into Xenopus laevis oocytes as a technique to study the effect of neurotoxicants on endogenous voltage-sensitive ion channels

(2017) Edwin Murenzi et al.   NEUROTOXICOLOGY

Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning

(2017) Michael R. Weed et al.   PLoS One

Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain

(2017) Haylie K. Romero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?

(2017) Dmitry Petrov et al.   Frontiers in Aging Neuroscience

The current agonists and positive allosteric modulators of α 7 nAChR for CNS indications in clinical trials

(2017) Taoyi Yang et al.   Acta Pharmaceutica Sinica B

The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis

(2016) Jean-Philippe Loeffler et al.   BRAIN PATHOLOGY

Drug treatments in Alzheimers disease

(2016) R. Briggs et al.   CLINICAL MEDICINE

Reconstitution of synaptic Ion channels from rodent and human brain inXenopusoocytes: a biochemical and electrophysiological characterization

(2016) Francesca Mazzo et al.   JOURNAL OF NEUROCHEMISTRY

Acetylcholine receptors from human muscle as pharmacological targets for ALS therapy

(2016) Eleonora Palma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular motions that shape the cardiac action potential: Insights from voltage clamp fluorometry

(2016) Wandi Zhu et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

On the Complexity of Brain Disorders: A Symptom-Based Approach

(2016) Ahmed A. Moustafa et al.   Frontiers in Computational Neuroscience

ABT-126 monotherapy in mild-to-moderate Alzheimer’s dementia: randomized double-blind, placebo and active controlled adaptive trial and open-label extension

(2016) Laura M. Gault et al.   Alzheimers Research & Therapy

Common Mechanisms Underlying Epileptogenesis and the Comorbidities of Epilepsy

(2016) Andrey Mazarati et al.   Cold Spring Harbor Perspectives in Medicine

Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy

(2016) Federico Sicca et al.   Scientific Reports

Lidocaine Preferentially Inhibits the Function of Purinergic P2X7 Receptors Expressed in Xenopus Oocytes

(2015) Dan Okura et al.   ANESTHESIA AND ANALGESIA

An oncologist׳s friend: How Xenopus contributes to cancer research

(2015) Laura J.A. Hardwick et al.   DEVELOPMENTAL BIOLOGY

Drugs for the treatment of peripheral neuropathies

(2015) Paola Marmiroli et al.   EXPERT OPINION ON PHARMACOTHERAPY

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Patch-Clamp Fluorometry: Electrophysiology meets Fluorescence

(2014) Jana Kusch et al.   BIOPHYSICAL JOURNAL

Real-Time Imaging of Electrical Signals with an Infrared FDA-Approved Dye

(2014) Jeremy S. Treger et al.   BIOPHYSICAL JOURNAL

Subtype selectivity of α+β− site ligands of GABAAreceptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors

(2013) Zdravko Varagic et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyotrophic Lateral Sclerosis Treatment with Ultramicronized Palmitoylethanolamide: A Case Report

(2013) Simonetta Clemente   CNS & Neurological Disorders-Drug Targets

Ion Channels as Drug Targets in Central Nervous System Disorders

(2013) A. M. Waszkielewicz et al.   CURRENT MEDICINAL CHEMISTRY

Modulation of the human ρ1 GABAA receptor by inhibitory steroids

(2013) Megan M. Eaton et al.   PSYCHOPHARMACOLOGY

Effects of pregabalin on the activity of glutamate transporter type 3

(2012) J.H. Ryu et al.   BRITISH JOURNAL OF ANAESTHESIA

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Live Imaging of Targeted Cell Ablation in Xenopus: A New Model to Study Demyelination and Repair

(2012) F. Kaya et al.   JOURNAL OF NEUROSCIENCE

Functional and structural effects of amyloid-β aggregate on Xenopus laevis oocytes

(2012) Jorge Parodi et al.   MOLECULES AND CELLS

Voltage clamp methods for the study of membrane currents and SR Ca2+ release in adult skeletal muscle fibres

(2012) Erick O. Hernández-Ochoa et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action

(2011) C Marques-da-Silva et al.   BRITISH JOURNAL OF PHARMACOLOGY

The use ofXenopusoocytes in drug screening

(2011) Trine Kvist et al.   Expert Opinion on Drug Discovery

Physiological characterization of human muscle acetylcholine receptors from ALS patients

(2011) E. Palma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational Control in Oocyte Development

(2011) J. D. Richter et al.   Cold Spring Harbor Perspectives in Biology

L-type calcium channels and psychiatric disorders: A brief review

(2010) Francesco Casamassima et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Cave Canalem: How endogenous ion channels may interfere with heterologous expression in Xenopus oocytes

(2010) Jan Terhag et al.   METHODS

Working with OpusXpress: Methods for high volume oocyte experiments

(2010) Roger L. Papke et al.   METHODS

Diarylamidines: High potency inhibitors of acid-sensing ion channels

(2010) Xuanmao Chen et al.   NEUROPHARMACOLOGY

KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate

(2010) J. D. Osteen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genome of the Western Clawed Frog Xenopus tropicalis

(2010) U. Hellsten et al.   SCIENCE

TC-5619: An alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia

(2009) T.A. Hauser et al.   BIOCHEMICAL PHARMACOLOGY

Pharmacodynamics of Memantine: An Update

(2008) C. Parsons et al.   Current Neuropharmacology

Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels

(2008) Toru Kobayashi et al.   NEUROPHARMACOLOGY

Microtransplantation of neurotransmitter receptors from postmortem autistic brains to Xenopus oocytes

(2008) A. Limon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Implications

(2007) Mauro Cozzolino et al.   ANTIOXIDANTS & REDOX SIGNALING

An automated system for intracellular and intranuclear injection

(2007) Ron C. Hogg et al.   JOURNAL OF NEUROSCIENCE METHODS