Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics

A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2

(2017) Jing Zhou et al.   Cell Reports

Morphogen interpretation: concentration, time, competence, and signaling dynamics

(2017) Andreas Sagner et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs

(2016) Eva Kutejova et al.   DEVELOPMENTAL CELL

Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis

(2016) Hiromi Shimojo et al.   GENES & DEVELOPMENT

Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq

(2016) Barbara Treutlein et al.   NATURE

Wishbone identifies bifurcating developmental trajectories from single-cell data

(2016) Manu Setty et al.   NATURE BIOTECHNOLOGY

Transition states and cell fate decisions in epigenetic landscapes

(2016) Naomi Moris et al.   NATURE REVIEWS GENETICS

Iterative Role of Notch Signaling in Spinal Motor Neuron Diversification

(2016) G. Christopher Tan et al.   Cell Reports

A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo

(2015) M. Stasiulewicz et al.   DEVELOPMENT

Notch Activity Modulates the Responsiveness of Neural Progenitors to Sonic Hedgehog Signaling

(2015) Jennifer H. Kong et al.   DEVELOPMENTAL CELL

Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2

(2014) Gary S McDowell et al.   BMC BIOCHEMISTRY

A theoretical framework for the regulation of Shh morphogen-controlled gene expression

(2014) M. Cohen et al.   DEVELOPMENT

An Amino Terminal Phosphorylation Motif Regulates Intranuclear Compartmentalization of Olig2 in Neural Progenitor Cells

(2014) D. H. Meijer et al.   JOURNAL OF NEUROSCIENCE

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

bHLH Factors in Self-Renewal, Multipotency, and Fate Choice of Neural Progenitor Cells

(2014) Itaru Imayoshi et al.   NEURON

Coordination of progenitor specification and growth in mouse and chick spinal cord

(2014) A. Kicheva et al.   SCIENCE

Motor neurons and the generation of spinal motor neuron diversity

(2014) Nicolas Stifani   Frontiers in Cellular Neuroscience

In Vitro Generation of Neuromesodermal Progenitors Reveals Distinct Roles for Wnt Signalling in the Specification of Spinal Cord and Paraxial Mesoderm Identity

(2014) Mina Gouti et al.   PLOS BIOLOGY

Integration of Signals along Orthogonal Axes of the Vertebrate Neural Tube Controls Progenitor Competence and Increases Cell Diversity

(2014) Noriaki Sasai et al.   PLOS BIOLOGY

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

Morphogen interpretation: the transcriptional logic of neural tube patterning

(2013) Michael Cohen et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization

(2013) Polyxeni Philippidou et al.   NEURON

SoxB1-driven transcriptional network underlies neural-specific interpretation of morphogen signals

(2013) T. Oosterveen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors

(2013) I. Imayoshi et al.   SCIENCE

PLZF Regulates Fibroblast Growth Factor Responsiveness and Maintenance of Neural Progenitors

(2013) Zachary B. Gaber et al.   PLOS BIOLOGY

Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

(2012) Nikolaos Balaskas et al.   CELL

Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation

(2012) C. Hindley et al.   DEVELOPMENT

NEUROG2 Drives Cell Cycle Exit of Neuronal Precursors by Specifically Repressing a Subset of Cyclins Acting at the G1 and S Phases of the Cell Cycle

(2012) M. Lacomme et al.   MOLECULAR AND CELLULAR BIOLOGY

Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2

(2012) Dimphna H. Meijer et al.   NATURE REVIEWS NEUROSCIENCE

Genome-Wide Analysis of N1ICD/RBPJ Targets In Vivo Reveals Direct Transcriptional Regulation of Wnt, SHH, and Hippo Pathway Effectors by Notch1

(2012) Yaochen Li et al.   STEM CELLS

The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma

(2011) Shwetal Mehta et al.   CANCER CELL

SnapShot: Spinal Cord Development

(2011) William A. Alaynick et al.   CELL

RP58/ZNF238 directly modulates proneurogenic gene levels and is required for neuronal differentiation and brain expansion

(2011) C Xiang et al.   CELL DEATH AND DIFFERENTIATION

Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

(2011) Esther Y. Son et al.   Cell Stem Cell

Regulation of spinal interneuron development by the Olig-related protein Bhlhb5 and Notch signaling

(2011) K. Skaggs et al.   DEVELOPMENT

Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis

(2011) F. Ali et al.   DEVELOPMENT

Phosphorylation Regulates OLIG2 Cofactor Choice and the Motor Neuron-Oligodendrocyte Fate Switch

(2011) Huiliang Li et al.   NEURON

Phosphorylation State of Olig2 Regulates Proliferation of Neural Progenitors

(2011) Yu Sun et al.   NEURON

Mir-17-3p Controls Spinal Neural Progenitor Patterning by Regulating Olig2/Irx3 Cross-Repressive Loop

(2011) Jun-An Chen et al.   NEURON

Emerging properties of animal gene regulatory networks

(2010) Eric H. Davidson   NATURE

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

(2010) Eric Dessaud et al.   PLOS BIOLOGY

Far-red fluorescent tags for protein imaging in living tissues

(2009) Dmitry Shcherbo et al.   BIOCHEMICAL JOURNAL

Establishing and Interpreting Graded Sonic Hedgehog Signaling during Vertebrate Neural Tube Patterning: The Role of Negative Feedback

(2009) V. Ribes et al.   Cold Spring Harbor Perspectives in Biology

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

(2008) C. E. Chamberlain et al.   DEVELOPMENT

Regulation of Motor Neuron Specification by Phosphorylation of Neurogenin 2

(2008) Yong-Chao Ma et al.   NEURON

Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors

(2008) Hiromi Shimojo et al.   NEURON