Histone deacetylase (HDAC) inhibitors and doxorubicin combinations target both breast cancer stem cells and non-stem breast cancer cells simultaneously

Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic data

(2019) Ke Liu et al.   Nature Communications

Identification of inhibitors synergizing gemcitabine sensitivity in the squamous subtype of pancreatic ductal adenocarcinoma (PDAC)

(2018) Jia Lin Er et al.   APOPTOSIS

Plasticity and intratumoural heterogeneity of cell surface antigen expression in breast cancer

(2018) Ján Remšík et al.   BRITISH JOURNAL OF CANCER

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

C-SPADE: a web-tool for interactive analysis and visualization of drug screening experiments through compound-specific bioactivity dendrograms

(2017) Balaguru Ravikumar et al.   NUCLEIC ACIDS RESEARCH

YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells

(2017) Chun-Chia Cheng et al.   PLoS One

Acetylation and deacetylation in cancer stem-like cells

(2017) Na Liu et al.   Oncotarget

Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping

(2017) Xiaofeng Dai et al.   Journal of Cancer

Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway

(2017) Hsien-Chuen Soo et al.   PLoS One

Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1)

(2017) Felicia Fei-Lei Chung et al.   Scientific Reports

Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis

(2017) Wenzhe Li et al.   Scientific Reports

Combenefit: an interactive platform for the analysis and visualization of drug combinations

(2016) Giovanni Y. Di Veroli et al.   BIOINFORMATICS

Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia

(2016) Elena Ceccacci et al.   BRITISH JOURNAL OF CANCER

Combining Epigenetic and Immunotherapy to Combat Cancer

(2016) Katherine B. Chiappinelli et al.   CANCER RESEARCH

Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer

(2016) A E Witt et al.   ONCOGENE

Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival

(2016) Kai Hung Tiong et al.   Oncotarget

Cancer Stem Cell Plasticity Drives Therapeutic Resistance

(2016) Mary Doherty et al.   Cancers

Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells

(2015) Jaslyn Sian-Siu Soo et al.   APOPTOSIS

Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery

(2015) Erica L. Stone et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel Histone Deacetylase Inhibitors Induce Growth Arrest, Apoptosis, and Differentiation in Sarcoma Cancer Stem Cells

(2015) Gemma Di Pompo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Melanoma cells influence the differentiation pattern of human epidermal keratinocytes

(2015) Ondřej Kodet et al.   Molecular Cancer

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

(2015) Devon A. Lawson et al.   NATURE

Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity

(2015) YEE-LIN VOON et al.   ONCOLOGY REPORTS

The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma

(2015) Monica Venere et al.   Science Translational Medicine

YM155 potently triggers cell death in breast cancer cells through an autophagy-NF-kB network

(2015) Eloïse Véquaud et al.   Oncotarget

Expression of Histone Deacetylases HDAC1, HDAC2, HDAC3, and HDAC6 in Invasive Ductal Carcinomas of the Breast

(2014) Jinwon Seo et al.   Journal of Breast Cancer

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective Activity of the Histone Deacetylase Inhibitor AR-42 against Leukemia Stem Cells: A Novel Potential Strategy in Acute Myelogenous Leukemia

(2014) M. L. Guzman et al.   MOLECULAR CANCER THERAPEUTICS

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

(2014) A. Janzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer - overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression

(2013) Berit Maria Müller et al.   BMC CANCER

The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

(2013) M. A. Salvador et al.   CLINICAL CANCER RESEARCH

A Phase I Study of Quisinostat (JNJ-26481585), an Oral Hydroxamate Histone Deacetylase Inhibitor with Evidence of Target Modulation and Antitumor Activity, in Patients with Advanced Solid Tumors

(2013) B. Venugopal et al.   CLINICAL CANCER RESEARCH

A possible usage of a CDK4 inhibitor for breast cancer stem cell-targeted therapy

(2012) Yu Kyeong Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Efficacy of everolimus, a novel mTOR inhibitor, against basal-like triple-negative breast cancer cells

(2012) Mayu Yunokawa et al.   CANCER SCIENCE

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo

(2012) Yuanxi Zhu et al.   TUMOR BIOLOGY

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

(2012) Geneviève P Delcuve et al.   Clinical Epigenetics

Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming

(2012) Androniki Kretsovali et al.   Stem Cells International

Suppression of BCL-2 synergizes cisplatin sensitivity in nasopharyngeal carcinoma cells

(2011) Soon Yang Low et al.   CANCER LETTERS

Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types

(2011) D. Iliopoulos et al.   CANCER RESEARCH

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

(2011) Seth A. Wander et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Epigenetic Regulation of miR-34a for Treatment of Pancreatic Cancer by Inhibition of Pancreatic Cancer Stem Cells

(2011) Dara Nalls et al.   PLoS One

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin synergizes cisplatin sensitivity in basal-like breast cancer cells through up-regulation of p73

(2010) Su Wei Wong et al.   BREAST CANCER RESEARCH AND TREATMENT

The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells

(2010) Alejandro Vazquez-Martin et al.   BREAST CANCER RESEARCH AND TREATMENT

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

HDAC6 is required for invadopodia activity and invasion by breast tumor cells

(2010) Mercedes Rey et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies

(2010)   LANCET ONCOLOGY

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

(2009) Emmanuelle Charafe-Jauffret et al.   CANCER RESEARCH

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL