Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming

Control of the Embryonic Stem Cell State

(2011) Richard A. Young   CELL

Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs

(2011) Norikatsu Miyoshi et al.   Cell Stem Cell

Gcm/Glide-dependent conversion into glia depends on neural stem cell age, but not on division, triggering a chromatin signature that is conserved in vertebrate glia

(2011) H. Flici et al.   DEVELOPMENT

HDAC inhibition promotes cardiogenesis and the survival of embryonic stem cells through proteasome-dependent pathway

(2011) Hong P. Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The regulatory role of histone deacetylase inhibitors in Fgf4 expression is dependent on the differentiation state of pluripotent stem cells

(2011) Guilai Shi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination

(2011) Ying Chen et al.   NATURE NEUROSCIENCE

Returning to the stem state: Epigenetics of recapitulating pre-differentiation chromatin structure

(2010) Mehdi Shafa et al.   BIOESSAYS

Effect of Trichostatin A on Chromatin Remodeling, Histone Modifications, DNA Replication, and Transcriptional Activity in Cloned Mouse Embryos1

(2010) Hong-Thuy Bui et al.   BIOLOGY OF REPRODUCTION

Inhibition of Class IIb Histone Deacetylase Significantly Improves Cloning Efficiency in Mice1

(2010) Tetsuo Ono et al.   BIOLOGY OF REPRODUCTION

Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice

(2010) Shinji Kaichi et al.   CARDIOVASCULAR RESEARCH

Directing cell differentiation with small-molecule histone deacetylase inhibitors: The example of promoting pancreatic endocrine cells

(2010) Cécile Haumaitre et al.   CELL CYCLE

Pre- and Postimplantation Development of Swine-Cloned Embryos Derived from Fibroblasts and Bone Marrow Cells after Inhibition of Histone Deacetylases

(2010) Mario A. Martinez-Diaz et al.   Cellular Reprogramming

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis

(2010) Roel H Wilting et al.   EMBO JOURNAL

Somatic Nucleus Reprogramming Is Significantly Improved bym-Carboxycinnamic Acid Bishydroxamide, a Histone Deacetylase Inhibitor

(2010) Xiangpeng Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Butyrate Promotes Induced Pluripotent Stem Cell Generation

(2010) Gaoyang Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extrinsic regulation of pluripotent stem cells

(2010) Martin F. Pera et al.   NATURE

Differentiation of non-mesencephalic neural stem cells towards dopaminergic neurons

(2010) R. Rößler et al.   NEUROSCIENCE

A Combined Epigenetic and Non-Genetic Approach for Reprogramming Human Somatic Cells

(2010) Jinnuo Han et al.   PLoS One

Direct Conversion of C. elegans Germ Cells into Specific Neuron Types

(2010) B. Tursun et al.   SCIENCE

Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes

(2010) Prashant Mali et al.   STEM CELLS

Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer

(2009) Oronza Antonietta Botrugno et al.   CANCER LETTERS

Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells

(2009) S. Lee et al.   CELL PROLIFERATION

Histone Deacetylase Inhibition Elicits an Evolutionarily Conserved Self-Renewal Program in Embryonic Stem Cells

(2009) Carol B. Ware et al.   Cell Stem Cell

Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells

(2009) Bo Feng et al.   Cell Stem Cell

Epigenetic reprogramming and induced pluripotency

(2009) K. Hochedlinger et al.   DEVELOPMENT

New patented histone deacetylase inhibitors

(2009) Haishan Wang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Expression Levels of Histone Deacetylases Determine the Cell Fate of Hematopoietic Progenitors

(2009) Taeko Wada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells

(2009) Meng Ren et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

(2009) Feng Ye et al.   NATURE NEUROSCIENCE

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development

(2009) R. L. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The histone deacetylase inhibitor scriptaid enhances nascent mRNA production and rescues full-term development in cloned inbred mice

(2009) Nguyen Van Thuan et al.   REPRODUCTION

Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming

(2008) Rudolf Jaenisch et al.   CELL

Capturing Pluripotency

(2008) Jose Silva et al.   CELL

Dynamic Equilibrium and Heterogeneity of Mouse Pluripotent Stem Cells with Distinct Functional and Epigenetic States

(2008) Katsuhiko Hayashi et al.   Cell Stem Cell

Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds

(2008) Yan Shi et al.   Cell Stem Cell

Eloquent silence: developmental functions of Class I histone deacetylases

(2008) Vincent T Cunliffe   CURRENT OPINION IN GENETICS & DEVELOPMENT

Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks

(2008) Sarah K Knutson et al.   EMBO JOURNAL

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

(2008) Rusty L. Montgomery et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone Deacetylase Inhibitors Modify Pancreatic Cell Fate Determination and Amplify Endocrine Progenitors

(2008) C. Haumaitre et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein Kinase D1 Stimulates MEF2 Activity in Skeletal Muscle and Enhances Muscle Performance

(2008) M.-S. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control

(2008) Srividya Bhaskara et al.   MOLECULAR CELL

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

(2008) Danwei Huangfu et al.   NATURE BIOTECHNOLOGY

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

(2008) Danwei Huangfu et al.   NATURE BIOTECHNOLOGY

Small-molecule activation of neuronal cell fate

(2008) Jay W Schneider et al.   Nature Chemical Biology

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation

(2008) In Tag Yu et al.   NEUROPHARMACOLOGY

Reprogramming Primordial Germ Cells into Pluripotent Stem Cells

(2008) Gabriela Durcova-Hills et al.   PLoS One

Nuclear Reprogramming in Cells

(2008) J. B. Gurdon et al.   SCIENCE

Pluripotency Associated Genes Are Reactivated by Chromatin-Modifying Agents in Neurosphere Cells

(2008) David Ruau et al.   STEM CELLS

Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis

(2008) Efthimia Karantzal et al.   GENOME BIOLOGY

Complementary roles for histone deacetylases 1, 2, and 3 in differentiation of pluripotent stem cells

(2007) Glen W. Humphrey et al.   DIFFERENTIATION