YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells

Survivin inhibitor YM155 suppresses gastric cancer xenograft growth in mice without affecting normal tissues

(2016) Xiao Jiao Cheng et al.   Oncotarget

The mechanism of acquired resistance to irreversible EGFR tyrosine kinase inhibitor-afatinib in lung adenocarcinoma patients

(2016) Shang-Gin Wu et al.   Oncotarget

Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin

(2016) Yiming Zhang et al.   Cancer Medicine

The H3K9 Methyltransferase G9a Represses E-cadherin and is Associated with Myometrial Invasion in Endometrial Cancer

(2015) Sheng-Mou Hsiao et al.   ANNALS OF SURGICAL ONCOLOGY

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

(2015) Hsin-Wei Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-induced cell stemness leads to drug resistance and poor prognosis in lung adenocarcinoma

(2015) Mingchuan Zhao et al.   LUNG CANCER

Suppression of cancer relapse and metastasis by inhibiting cancer stemness

(2015) Youzhi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGFR and NF-κB: partners in cancer

(2015) Kateryna Shostak et al.   TRENDS IN MOLECULAR MEDICINE

G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma

(2015) Shuli Liu et al.   Oncotarget

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics

(2014) Carlos L. Arteaga et al.   CANCER CELL

EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation

(2014) M. Wang et al.   CANCER RESEARCH

Afatinib Enhances the Efficacy of Conventional Chemotherapeutic Agents by Eradicating Cancer Stem-like Cells

(2014) X.-k. Wang et al.   CANCER RESEARCH

Antibody Against CD44s Inhibits Pancreatic Tumor Initiation and Postradiation Recurrence in Mice

(2014) Ling Li et al.   GASTROENTEROLOGY

Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP

(2013) Feng Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Afatinib Prolongs Survival Compared with Gefitinib in an Epidermal Growth Factor Receptor-Driven Lung Cancer Model

(2013) T. Ninomiya et al.   MOLECULAR CANCER THERAPEUTICS

Afatinib—new therapy option for EGFR-mutant lung cancer

(2013) Helena A. Yu et al.   Nature Reviews Clinical Oncology

G9a, a multipotent regulator of gene expression

(2012) Shilpa Rani Shankar et al.   Epigenetics

Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription

(2012) Daniel J. Purcell et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Phosphorylated EGFR expression may predict outcome of EGFR-TKIs therapy for the advanced NSCLC patients with wild-type EGFR

(2012) Fen Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Interleukin Enhancer-binding Factor 3/NF110 Is a Target of YM155, a Suppressant of Survivin

(2012) Naoto Nakamura et al.   MOLECULAR & CELLULAR PROTEOMICS

The EGFR T790M Mutation in Acquired Resistance to an Irreversible Second-Generation EGFR Inhibitor

(2012) Y. Kim et al.   MOLECULAR CANCER THERAPEUTICS

YM155 Induces EGFR Suppression in Pancreatic Cancer Cells

(2012) Young-Soon Na et al.   PLoS One

G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of Glucocorticoid Receptor target genes

(2012) D. Bittencourt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HER2 Amplification: A Potential Mechanism of Acquired Resistance to EGFR Inhibition in EGFR -Mutant Lung Cancers That Lack the Second-Site EGFR T790M Mutation

(2012) Ken Takezawa et al.   Cancer Discovery

A role for cancer stem cells in drug resistance and metastasis in non-small-cell lung cancer

(2011) Rosario Perona et al.   Clinical & Translational Oncology

Afatinib (BIBW 2992) development in non-small-cell lung cancer

(2011) Vera Hirsh   Future Oncology

H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM

(2010) M.-W. Chen et al.   CANCER RESEARCH

G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53

(2010) Jing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Imaging, Tracking, and Targeting of Cancer Stem Cells

(2009) Erina Vlashi et al.   JNCI-Journal of the National Cancer Institute