Discovery and metabolic engineering of iridoid/secoiridoid and monoterpenoid indole alkaloid biosynthesis

Exploiting plant alkaloids

(2016) Sabrina Schläger et al.   CURRENT OPINION IN BIOTECHNOLOGY

Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids

(2015) Franziska Kellner et al.   CHEMICAL COMMUNICATIONS

Unlocking the Diversity of Alkaloids in Catharanthus roseus: Nuclear Localization Suggests Metabolic Channeling in Secondary Metabolism

(2015) Anna Stavrinides et al.   CHEMISTRY & BIOLOGY

Iridoid Synthase Activity Is Common among the Plant Progesterone 5β-Reductase Family

(2015) Jennifer Munkert et al.   Molecular Plant

Structural determinants of reductive terpene cyclization in iridoid biosynthesis

(2015) Hajo Kries et al.   Nature Chemical Biology

Phytochemical genomics of the Madagascar periwinkle: Unravelling the last twists of the alkaloid engine

(2015) Thomas Dugé de Bernonville et al.   PHYTOCHEMISTRY

Genome-guided investigation of plant natural product biosynthesis

(2015) Franziska Kellner et al.   PLANT JOURNAL

Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast

(2015) Yang Qu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo production of the plant-derived alkaloid strictosidine in yeast

(2015) Stephanie Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway inCatharanthus roseus

(2015) Alex Van Moerkercke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Making iridoids/secoiridoids and monoterpenoid indole alkaloids: progress on pathway elucidation

(2014) Vincenzo De Luca et al.   CURRENT OPINION IN PLANT BIOLOGY

7-Deoxyloganetic acid synthase catalyzes a key 3 step oxidation to form 7-deoxyloganetic acid in Catharanthus roseus iridoid biosynthesis

(2014) Vonny Salim et al.   PHYTOCHEMISTRY

Transcriptional regulation of secondary metabolite biosynthesis in plants

(2013) Barunava Patra et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway

(2013) Chun Li et al.   BMC PLANT BIOLOGY

Transcriptome analysis based on next-generation sequencing of non-model plants producing specialized metabolites of biotechnological interest

(2013) Mei Xiao et al.   JOURNAL OF BIOTECHNOLOGY

A 7-Deoxyloganetic Acid Glucosyltransferase Contributes a Key Step in Secologanin Biosynthesis in Madagascar Periwinkle

(2013) K. Asada et al.   PLANT CELL

Virus-induced gene silencing identifiesCatharanthus roseus7-deoxyloganic acid-7-hydroxylase, a step in iridoid and monoterpene indole alkaloid biosynthesis

(2013) Vonny Salim et al.   PLANT JOURNAL

A Pair of Tabersonine 16-Hydroxylases Initiates the Synthesis of Vindoline in an Organ-Dependent Manner in Catharanthus roseus

(2013) S. Besseau et al.   PLANT PHYSIOLOGY

Promoter analysis reveals cis-regulatory motifs associated with the expression of the WRKY transcription factor CrWRKY1 in Catharanthus roseus

(2013) Zhirong Yang et al.   PLANTA

ATP-binding cassette transporter controls leaf surface secretion of anticancer drug components in Catharanthus roseus

(2013) F. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A type-B response regulator drives the expression of the hydroxymethylbutenyl diphosphate synthase gene in periwinkle

(2012) Olivia Ginis et al.   JOURNAL OF PLANT PHYSIOLOGY

An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis

(2012) Fernando Geu-Flores et al.   NATURE

Characterization of the plastidial geraniol synthase from Madagascar periwinkle which initiates the monoterpenoid branch of the alkaloid pathway in internal phloem associated parenchyma

(2012) Andrew J. Simkin et al.   PHYTOCHEMISTRY

AP2/ERF family transcription factors in plant abiotic stress responses

(2011) Junya Mizoi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A Stereoselective Hydroxylation Step of Alkaloid Biosynthesis by a Unique Cytochrome P450 inCatharanthus roseus

(2011) Lesley-Ann Giddings et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular cloning and functional characterization of Catharanthus roseus hydroxymethylbutenyl 4-diphosphate synthase gene promoter from the methyl erythritol phosphate pathway

(2011) Olivia Ginis et al.   MOLECULAR BIOLOGY REPORTS

A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus

(2011) David K. Liscombe et al.   PHYTOCHEMISTRY

The Jasmonate-Responsive Element from the ORCA3 Promoter from Catharanthus roseus is Active in Arabidopsis and is Controlled by the Transcription Factor AtMYC2

(2011) Gregory Montiel et al.   PLANT AND CELL PHYSIOLOGY

Negative Regulation of Anthocyanin Biosynthesis inArabidopsisby a miR156-Targeted SPL Transcription Factor

(2011) Jin-Ying Gou et al.   PLANT CELL

Functional analysis of the DAT gene promoter using transient Catharanthus roseus and stable Nicotiana tabacum transformation systems

(2011) Abdullah Makhzoum et al.   PLANT CELL REPORTS

The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus

(2011) Hongtao Zhang et al.   PLANT JOURNAL

The Transcription Factor CrWRKY1 Positively Regulates the Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus

(2011) N. Suttipanta et al.   PLANT PHYSIOLOGY

Synthetic biosystems for the production of high-value plant metabolites

(2011) Peter J. Facchini et al.   TRENDS IN BIOTECHNOLOGY

Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor

(2010) Laura B. Sheard et al.   NATURE

NINJA connects the co-repressor TOPLESS to jasmonate signalling

(2010) Laurens Pauwels et al.   NATURE

Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis

(2010) D. K. Liscombe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vinca drug components accumulate exclusively in leaf exudates of Madagascar periwinkle

(2010) J. Roepke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two distinct intracellular Ca2+-release components act in opposite ways in the regulation of the auxin-dependent MIA biosynthesis in Catharanthus roseus cells

(2009) Pierre Poutrain et al.   JOURNAL OF EXPERIMENTAL BOTANY

Isolation and functional analysis of the Catharanthus roseus deacetylvindoline-4-O-acetyltransferase gene promoter

(2009) Quan Wang et al.   PLANT CELL REPORTS

Spatial and Temporal Dynamics of Jasmonate Synthesis and Accumulation inArabidopsisin Response to Wounding

(2008) Gaetan Glauser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time

(2008) Christie A.M. Peebles et al.   METABOLIC ENGINEERING

The Leaf Epidermome of Catharanthus roseus Reveals Its Biochemical Specialization

(2008) J. Murata et al.   PLANT CELL

Proteins prenylated by type I protein geranylgeranyltransferase act positively on the jasmonate signalling pathway triggering the biosynthesis of monoterpene indole alkaloids in Catharanthus roseus

(2008) Vincent Courdavault et al.   PLANT CELL REPORTS

Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants

(2008) Peter J. Facchini et al.   PLANT JOURNAL

Direct Coupling of Catharanthine and Vindoline to Provide Vinblastine:  Total Synthesis of (+)- andent-(−)-Vinblastine

(2007) Hayato Ishikawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY