The Role of Astrocyte Mitochondria in Differential Regional Susceptibility to Environmental Neurotoxicants: Tools for Understanding Neurodegeneration

Lenti-GDNF Gene Therapy Protects Against Alzheimer's Disease-Like Neuropathology in 3xTg-AD Mice and MC65 Cells

(2014) Susana Revilla et al.   CNS Neuroscience & Therapeutics

Astroglial heme oxygenase-1 and the origin of corpora amylacea in aging and degenerating neural tissues

(2014) Wei Song et al.   EXPERIMENTAL NEUROLOGY

Ephrin-A3 reverse signaling regulates hippocampal neuronal damage and astrocytic glutamate transport after transient global ischemia

(2014) Jinshan Yang et al.   JOURNAL OF NEUROCHEMISTRY

Neuronal Activity and Glutamate Uptake Decrease Mitochondrial Mobility in Astrocytes and Position Mitochondria Near Glutamate Transporters

(2014) J. G. Jackson et al.   JOURNAL OF NEUROSCIENCE

Pharmacologically controlled, discontinuous GDNF gene therapy restores motor function in a rat model of Parkinson's disease

(2014) Julia Tereshchenko et al.   NEUROBIOLOGY OF DISEASE

Endogenous Dopamine Is Involved in the Herbicide Paraquat-Induced Dopaminergic Cell Death

(2014) Yasuhiko Izumi et al.   TOXICOLOGICAL SCIENCES

Astrocytes protect against diazinon- and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathione

(2014) Daniella M. Pizzurro et al.   TOXICOLOGY

The glial response to intracerebrally delivered therapies for neurodegenerative disorders: is this a critical issue?

(2014) Francesca Cicchetti et al.   Frontiers in Pharmacology

Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain

(2013) Sean D. Taylor et al.   AGING CELL

Epoxyeicosatrienoic acids pretreatment improves amyloid β-induced mitochondrial dysfunction in cultured rat hippocampal astrocytes

(2013) Pallabi Sarkar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Modeling the Neuroprotective Role of Enhanced Astrocyte Mitochondrial Metabolism during Stroke

(2013) Casey O. Diekman et al.   BIOPHYSICAL JOURNAL

Decline in cytochrome c oxidase activity in rat-brain mitochondria with aging. Role of peroxidized cardiolipin and beneficial effect of melatonin

(2013) Giuseppe Petrosillo et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Differential effects of ethanol on regional glutamatergic and GABAergic neurotransmitter pathways in mouse brain

(2013) Vivek Tiwari et al.   JOURNAL OF NEUROCHEMISTRY

GABAA Receptor Agonist and Antagonist Alter Vestibular Compensation and Different Steps of Reactive Neurogenesis in Deafferented Vestibular Nuclei of Adult Cats

(2013) S. Dutheil et al.   JOURNAL OF NEUROSCIENCE

Thiamine deficiency induces oxidative stress in brain mitochondria of Mus musculus

(2013) Anupama Sharma et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

The current and projected economic burden of Parkinson's disease in the United States

(2013) Stacey L. Kowal et al.   MOVEMENT DISORDERS

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease

(2013) Willem Kamphuis et al.   NEUROBIOLOGY OF AGING

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Partial recovery of the damaged rat blood–brain barrier is mediated by adherens junction complexes, extracellular matrix remodeling and macrophage infiltration following focal astrocyte loss

(2013) C.L. Willis et al.   NEUROSCIENCE

Comparative study of the neurotrophic effects elicited by VEGF-B and GDNF in preclinical in vivo models of Parkinson’s disease

(2013) X. Yue et al.   NEUROSCIENCE

The Role of Autophagy Dysregulation in Manganese-Induced Dopaminergic Neurodegeneration

(2013) Jianbin Zhang et al.   NEUROTOXICITY RESEARCH

A comparative study of protein carbonylation and mitochondrial dysfunction using the neurotoxicants 1,3-dinitrobenzene, 3-nitropropionic acid, and 3-chloropropanediol

(2013) Stephen R. Steiner et al.   NEUROTOXICOLOGY

Opening of Astrocytic Mitochondrial ATP-Sensitive Potassium Channels Upregulates Electrical Coupling between Hippocampal Astrocytes in Rat Brain Slices

(2013) Jiangping Wang et al.   PLoS One

Age-Related Decline in Oligodendrogenesis Retards White Matter Repair in Mice

(2013) Nobukazu Miyamoto et al.   STROKE

The Role of Astrocytes in the Regulation of Synaptic Plasticity and Memory Formation

(2013) Yusuke Ota et al.   NEURAL PLASTICITY

Astrocytes convert network excitation to tonic inhibition of neurons

(2012) László Héja et al.   BMC BIOLOGY

Glial Cell Line-Derived Neurotrophic Factor Partially Ameliorates Motor Symptoms without Slowing Neurodegeneration in Mice with Respiratory Chain-Deficient Dopamine Neurons

(2012) Fredrik H. Sterky et al.   CELL TRANSPLANTATION

Heterosynaptic long-term depression mediated by ATP released from astrocytes

(2012) Jiadong Chen et al.   GLIA

Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum

(2012) Clare Howarth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte- neuron interaction as a mechanism responsible for generation of neural synchrony: a study based on modeling and experiments

(2012) Mahmood Amiri et al.   JOURNAL OF COMPUTATIONAL NEUROSCIENCE

Progressive limb ataxia following inferior olive lesions

(2012) K. M. Horn et al.   JOURNAL OF PHYSIOLOGY-LONDON

Early Induction of Oxidative Stress in Mouse Model of Alzheimer Disease with Reduced Mitochondrial Superoxide Dismutase Activity

(2012) Hyun-Pil Lee et al.   PLoS One

GFAP Isoforms in Adult Mouse Brain with a Focus on Neurogenic Astrocytes and Reactive Astrogliosis in Mouse Models of Alzheimer Disease

(2012) Willem Kamphuis et al.   PLoS One

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and mitochondrial deficits

(2011) Andrew Sauerbeck et al.   EXPERIMENTAL NEUROLOGY

Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems

(2011) Raquel Bajo-Grañeras et al.   GLIA

Influence of aging on membrane permeability transition in brain mitochondria

(2011) Julia Toman et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

DJ-1 deficiency in astrocytes selectively enhances mitochondrial Complex I inhibitor-induced neurotoxicity

(2011) Steven J. Mullett et al.   JOURNAL OF NEUROCHEMISTRY

Astrocytes Display Complex and Localized Calcium Responses to Single-Neuron Stimulation in the Hippocampus

(2011) Y. Bernardinelli et al.   JOURNAL OF NEUROSCIENCE

Co-compartmentalization of the Astroglial Glutamate Transporter, GLT-1, with Glycolytic Enzymes and Mitochondria

(2011) E. N. Genda et al.   JOURNAL OF NEUROSCIENCE

Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability

(2011) Syama Sundar Boyalla et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Hearing Loss Prevalence and Risk Factors Among Older Adults in the United States

(2011) F. R. Lin et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection

(2011) Francesca L'Episcopo et al.   Molecular Neurodegeneration

Toxicological assessment of 3-chloropropane-1,2-diol and glycidol fatty acid esters in food

(2011) Nadiya Bakhiya et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Efficient Gene Therapy for Parkinson's Disease Using Astrocytes as Hosts for Localized Neurotrophic Factor Delivery

(2011) Anja Drinkut et al.   MOLECULAR THERAPY

A review of the structural alterations in the cerebral hemispheres of the aging rhesus monkey

(2011) Alan Peters et al.   NEUROBIOLOGY OF AGING

Up-regulation of metallothionein gene expression in Parkinsonian astrocytes

(2011) Gregory J. Michael et al.   NEUROGENETICS

Neurotoxic (+)-methamphetamine treatment in rats increases brain-derived neurotrophic factor and tropomyosin receptor kinase B expression in multiple brain regions

(2011) A.A. Braun et al.   NEUROSCIENCE

DJ-1 knock-down impairs astrocyte mitochondrial function

(2011) N.J. Larsen et al.   NEUROSCIENCE

Proteomic identification of carbonylated proteins in 1,3-dinitrobenzene neurotoxicity

(2011) Stephen R. Steiner et al.   NEUROTOXICOLOGY

GFAP in health and disease

(2011) J. Middeldorp et al.   PROGRESS IN NEUROBIOLOGY

Mixed Inhibition of Adenosine Deaminase Activity by 1,3-Dinitrobenzene: A Model for Understanding Cell-Selective Neurotoxicity in Chemically-Induced Energy Deprivation Syndromes in Brain

(2011) Yipei Wang et al.   TOXICOLOGICAL SCIENCES

1,3-Dinitrobenzene–Induced Metabolic Impairment through Selective Inactivation of the Pyruvate Dehydrogenase Complex

(2011) James A. Miller et al.   TOXICOLOGICAL SCIENCES

The Expanding Universe of Neurotrophic Factors: Therapeutic Potential in Aging and Age-Associated Disorders

(2010) C. Lanni et al.   CURRENT PHARMACEUTICAL DESIGN

Differential susceptibility of astrocytic and neuronal function to 3-chloropropanediol in the rat inferior colliculus

(2010) Angus M. Brown et al.   JOURNAL OF NEUROCHEMISTRY

Redox proteomics in aging rat brain: Involvement of mitochondrial reduced glutathione status and mitochondrial protein oxidation in the aging process

(2010) M. Perluigi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Protective Role of d-Glucose Against 1-Methyl-4-Phenylpyridinium Ion (MPP+): Induced Mitochondrial Dysfunction in C6 Astroglial Cells

(2010) Ramesh B. Badisa et al.   NEUROCHEMICAL RESEARCH

Purinergic Receptor Stimulation Reduces Cytotoxic Edema and Brain Infarcts in Mouse Induced by Photothrombosis by Energizing Glial Mitochondria

(2010) Wei Zheng et al.   PLoS One

Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome

(2010) A. Quintana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo and in vitro assessment of brain bioenergetics in aging rats

(2009) Ol’ga Vančová et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Rescue of Aβ1-42-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer’s disease

(2009) Marie E. Gibbs et al.   JOURNAL OF NEUROCHEMISTRY

Memory performance is related to amyloid and tau pathology in the hippocampus

(2009) C Reitz et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Oxidative Inactivation of Mitochondrial Aconitase Results in Iron and H2O2-Mediated Neurotoxicity in Rat Primary Mesencephalic Cultures

(2009) David Cantu et al.   PLoS One

Role of Vestibular Input in Triggering and Modulating Postural Responses in Unilateral and Bilateral Vestibular Loss Patients

(2008) F. Mbongo et al.   AUDIOLOGY AND NEURO-OTOLOGY

Polyglutamine gene function and dysfunction in the ageing brain

(2008) Sarah Hands et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures

(2008) Zhaoobao Yin et al.   BRAIN RESEARCH

Metabolic Challenge to Glia Activates an Adenosine-Mediated Safety Mechanism that Promotes Neuronal Survival by Delaying the Onset of Spreading Depression Waves

(2008) Santiago Canals et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Iptakalim ameliorates MPP+-induced astrocyte mitochondrial dysfunction by increasing mitochondrial complex activity besides opening mitoKATPchannels

(2008) Shu Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH