Lysosomal Membrane Proteins and Their Central Role in Physiology

Proteolytic cleavage of the disease-related lysosomal membrane glycoprotein CLN7

(2012) Pieter Steenhuis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx

(2012) Sonja Wilke et al.   BMC BIOLOGY

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Ebola virus entry requires the host-programmed recognition of an intracellular receptor

(2012) Emily Happy Miller et al.   EMBO JOURNAL

The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2

(2012) O. Demirel et al.   JOURNAL OF CELL SCIENCE

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

(2012) Janna Schneppenheim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human SCARB2-Dependent Infection by Coxsackievirus A7, A14, and A16 and Enterovirus 71

(2012) S. Yamayoshi et al.   JOURNAL OF VIROLOGY

TM7SF1 (GPR137B): a novel lysosome integral membrane protein

(2012) Jialin Gao et al.   MOLECULAR BIOLOGY REPORTS

Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism

(2012) David Coelho et al.   NATURE GENETICS

Human SCARB2-Mediated Entry and Endocytosis of EV71

(2012) Yi-Wen Lin et al.   PLoS One

Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy

(2012) A. Jezegou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LAAT-1 Is the Lysosomal Lysine/Arginine Transporter That Maintains Amino Acid Homeostasis

(2012) B. Liu et al.   SCIENCE

A Critical Histidine Residue Within LIMP-2 Mediates pH Sensitive Binding to Its Ligand β-Glucocerebrosidase

(2012) Christina Zachos et al.   TRAFFIC

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Scavenger Receptor B2 as a Receptor for Hand, Foot, and Mouth Disease and Severe Neurological Diseases

(2012) Seiya Yamayoshi et al.   Frontiers in Microbiology

V-ATPase engagement in autophagic processes

(2011) Dalibor Mijaljica et al.   Autophagy

Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L

(2011) Lalu Rudyat Telly Savalas et al.   BIOCHEMICAL JOURNAL

Specific functions of lysosomal proteases in endocytic and autophagic pathways

(2011) Sabrina Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin

(2011) E. L. Doyle et al.   BLOOD

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

ClC-7 is a slowly voltage-gated 2Cl−/1H+-exchanger and requires Ostm1 for transport activity

(2011) Lilia Leisle et al.   EMBO JOURNAL

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail

(2011) Jörg Behnke et al.   FEBS LETTERS

LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV

(2011) S. Vergarajauregui et al.   JOURNAL OF CELL SCIENCE

Identification of a Human SCARB2 Region That Is Important for Enterovirus 71 Binding and Infection

(2011) S. Yamayoshi et al.   JOURNAL OF VIROLOGY

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Regulation and Isoform Function of the V-ATPases

(2010) Masashi Toei et al.   BIOCHEMISTRY

Ion flux and the function of endosomes and lysosomes: pH is just the start

(2010) Cameron C. Scott et al.   BIOESSAYS

Molecular characterisation of ‘transmembrane protein 192’ (TMEM192), a novel protein of the lysosomal membrane

(2010) Bernd Schröder et al.   BIOLOGICAL CHEMISTRY

The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor

(2010) T. Vaccari et al.   DEVELOPMENT

Analysis of the Biogenesis of Heparan Sulfate Acetyl-CoA:α-GlucosaminideN-Acetyltransferase Provides Insights into the Mechanism Underlying Its Complete Deficiency in Mucopolysaccharidosis IIIC

(2010) Stéphanie Durand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A cation counterflux supports lysosomal acidification

(2010) Benjamin E. Steinberg et al.   JOURNAL OF CELL BIOLOGY

Palmitoylation-dependent association with CD63 targets the Ca2+sensor synaptotagmin VII to lysosomes

(2010) Andrew R. Flannery et al.   JOURNAL OF CELL BIOLOGY

Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches

(2010) Anton I. Rosenbaum et al.   JOURNAL OF NEUROCHEMISTRY

The proteome of lysosomes

(2010) Bernd A. Schröder et al.   PROTEOMICS

Lysosomal Pathology and Osteopetrosis upon Loss of H+-Driven Lysosomal Cl- Accumulation

(2010) S. Weinert et al.   SCIENCE

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

NCU-G1 is a highly glycosylated integral membrane protein of the lysosome

(2009) Oliver Schieweck et al.   BIOCHEMICAL JOURNAL

Intramembrane Proteolysis

(2009) Michael S. Wolfe   CHEMICAL REVIEWS

The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila

(2009) Yan Yan et al.   DEVELOPMENTAL CELL

Impaired Autolysosome Formation Correlates With Lamp-2 Depletion: Role of Apoptosis, Autophagy, and Necrosis in Pancreatitis

(2009) Franco Fortunato et al.   GASTROENTEROLOGY

Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand β-glucocerebrosidase

(2009) Judith Blanz et al.   HUMAN MOLECULAR GENETICS

Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification

(2009) G.-H. Sun-Wada et al.   JOURNAL OF CELL SCIENCE

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism

(2009) Frank Rutsch et al.   NATURE GENETICS

Scavenger receptor B2 is a cellular receptor for enterovirus 71

(2009) Seiya Yamayoshi et al.   NATURE MEDICINE

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteomics of the lysosome

(2008) Torben Lübke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular and cellular basis of lysosomal transmembrane protein dysfunction

(2008) Raquel Ruivo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sorting of lysosomal proteins

(2008) Thomas Braulke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo

(2008) Francesca Peri et al.   CELL

Neuraminidase 1 Is a Negative Regulator of Lysosomal Exocytosis

(2008) Gouri Yogalingam et al.   DEVELOPMENTAL CELL

Deficiency of the Tetraspanin CD63 Associated with Kidney Pathology but Normal Lysosomal Function

(2008) J. Schroder et al.   MOLECULAR AND CELLULAR BIOLOGY

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes

(2008) Austin R. Graves et al.   NATURE