Griffithsin Retains Anti-HIV-1 Potency with Changes in gp120 Glycosylation and Complements Broadly Neutralizing Antibodies PGT121 and PGT126

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic

(2019) Marina Caskey et al.   NATURE MEDICINE

Development of a Vaginal Fast-Dissolving Insert Combining Griffithsin and Carrageenan for Potential Use Against Sexually Transmitted Infections

(2018) Manjari Lal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Therapeutic Efficacy of Vectored PGT121 Gene Delivery in HIV-1-Infected Humanized Mice

(2018) Alexander Badamchi-Zadeh et al.   JOURNAL OF VIROLOGY

Impact of the griffithsin anti-HIV microbicide and placebo gels on the rectal mucosal proteome and microbiome in non-human primates

(2018) Lauren Girard et al.   Scientific Reports

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

(2018) Xiaochu Ma et al.   eLife

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

(2018) Nina Derby et al.   Nature Communications

Randomized Clinical Trial to Assess the Impact of the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01 on HIV-1 Persistence in Individuals on Effective ART

(2018) Sharon A Riddler et al.   Open Forum Infectious Diseases

Protective Efficacy of Broadly Neutralizing Antibodies with Incomplete Neutralization Activity against Simian-Human Immunodeficiency Virus in Rhesus Monkeys

(2017) Boris Julg et al.   JOURNAL OF VIROLOGY

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Microsecond Dynamics and Network Analysis of the HIV-1 SOSIP Env Trimer Reveal Collective Behavior and Conserved Microdomains of the Glycan Shield

(2017) Thomas Lemmin et al.   STRUCTURE

Broadly Neutralizing Antibodies as Treatment: Effects on Virus and Immune System

(2017) Jinal N. Bhiman et al.   Current HIV/AIDS Reports

Stabilization and Sustained Release of HIV Inhibitors by Encapsulation in Silk Fibroin Disks

(2017) Li Zhang et al.   ACS Biomaterials-Science & Engineering

Stabilization and Sustained Release of HIV Inhibitors by Encapsulation in Silk Fibroin Disks

(2017) Li Zhang et al.   ACS Biomaterials Science & Engineering

Neutralizing antibody affords comparable protection against vaginal and rectal simian/human immunodeficiency virus challenge in macaques

(2016) Brian Moldt et al.   AIDS

Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin

(2016) Jean K. Millet et al.   ANTIVIRAL RESEARCH

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

(2016) Guillaume B.E. Stewart-Jones et al.   CELL

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth

(2016) Jinghe Huang et al.   IMMUNITY

HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual

(2016) Karen P. Coss et al.   JOURNAL OF VIROLOGY

Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women

(2016) Annalene Nel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

(2016) Jared M. Baeten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV

(2016) Evangelia Vamvaka et al.   PLANT BIOTECHNOLOGY JOURNAL

Pharmacokinetics of the Antiviral Lectin Griffithsin Administered by Different Routes Indicates Multiple Potential Uses

(2016) Christopher Barton et al.   Viruses-Basel

Studies in a Murine Model Confirm the Safety of Griffithsin and Advocate Its Further Development as a Microbicide Targeting HIV-1 and Other Enveloped Viruses

(2016) Joseph Kouokam et al.   Viruses-Basel

Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential

(2016) Sabrina Lusvarghi et al.   Viruses-Basel

Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization

(2016) Cecilia Rademeyer et al.   PLoS Pathogens

Binding Site Geometry and Subdomain Valency Control Effects of Neutralizing Lectins on HIV-1 Viral Particles

(2016) Sabrina Lusvarghi et al.   ACS Infectious Diseases

Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus

(2015) Keith Levendosky et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Improving the large scale purification of the HIV microbicide, griffithsin

(2015) Joshua L Fuqua et al.   BMC BIOTECHNOLOGY

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans

(2015) Fernando Garces et al.   IMMUNITY

Sensitivity of transmitted and founder human immunodeficiency virus type 1 envelopes to carbohydrate-binding agents griffithsin, cyanovirin-N and Galanthus nivalis agglutinin

(2015) Bodan Hu et al.   JOURNAL OF GENERAL VIROLOGY

Lectins with Anti-HIV Activity: A Review

(2015) Ouafae Akkouh et al.   MOLECULES

Antibody responses to envelope glycoproteins in HIV-1 infection

(2015) Dennis R Burton et al.   NATURE IMMUNOLOGY

Tenofovir-Based Preexposure Prophylaxis for HIV Infection among African Women

(2015) Jeanne M. Marrazzo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bulk production of the antiviral lectin griffithsin

(2015) Joshua L. Fuqua et al.   PLANT BIOTECHNOLOGY JOURNAL

Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262

(2015) Leopold Kong et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus

(2015) Tinoush Moulaei et al.   Retrovirology

HIV broadly neutralizing antibody targets

(2015) Constantinos Kurt Wibmer et al.   Current Opinion in HIV and AIDS

Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers

(2015) Laura K. Pritchard et al.   Cell Reports

Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies

(2014) Fernando Garces et al.   CELL

An Intravaginal Ring for the Sustained Delivery of Antibodies

(2014) Manjula Gunawardana et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Modular Cloning Toolbox for the Generation of Chloroplast Transformation Vectors

(2014) Yavar Vafaee et al.   PLoS One

Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV

(2014) D. Sok et al.   Science Translational Medicine

Efficient Single Tobamoviral Vector-Based Bioproduction of Broadly Neutralizing Anti-HIV-1 Monoclonal Antibody VRC01 in Nicotiana benthamiana Plants and Utility of VRC01 in Combination Microbicides

(2013) Krystal Teasley Hamorsky et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Griffithsin Dimer Is Required for High-Potency Inhibition of HIV-1: Evidence for Manipulation of the Structure of gp120 as Part of the Griffithsin Dimer Mechanism

(2013) Jie Xue et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity of and Effect of Subcutaneous Treatment with the Broad-Spectrum Antiviral Lectin Griffithsin in Two Laboratory Rodent Models

(2013) Christopher Barton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Entry inhibitors and their use in the treatment of HIV-1 infection

(2013) Aiman A. Haqqani et al.   ANTIVIRAL RESEARCH

Griffithsin Protects Mice from Genital Herpes by Preventing Cell-to-Cell Spread

(2013) B. Nixon et al.   JOURNAL OF VIROLOGY

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

(2013) Dan H. Barouch et al.   NATURE

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

(2013) Leopold Kong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges

(2013) J. M. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN

(2013) Kabamba B. Alexandre et al.   VIROLOGY

Evidence for a Continuous Drift of the HIV-1 Species towards Higher Resistance to Neutralizing Antibodies over the Course of the Epidemic

(2013) Mélanie Bouvin-Pley et al.   PLoS Pathogens

Combinations of Griffithsin with Other Carbohydrate-Binding Agents Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate-Binding Agent-Resistant HIV Type 1 Strains

(2012) Geoffrey Férir et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo

(2012) Hassan Z. A. Ishag et al.   ARCHIVES OF VIROLOGY

The Role of Individual Carbohydrate-Binding Sites in the Function of the Potent Anti-HIV Lectin Griffithsin

(2012) Jie Xue et al.   MOLECULAR PHARMACEUTICS

Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape

(2012) Penny L Moore et al.   NATURE MEDICINE

Griffithsin Has Antiviral Activity against Hepatitis C Virus

(2011) Philip Meuleman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Highly Potent Chimeric Inhibitors Targeting Two Steps of HIV Cell Entry

(2011) Bo Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin

(2011) X. Huang et al.   JOURNAL OF GENERAL VIROLOGY

Binding of the Mannose-Specific Lectin, Griffithsin, to HIV-1 gp120 Exposes the CD4-Binding Site

(2011) K. B. Alexandre et al.   JOURNAL OF VIROLOGY

Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate

(2011) Joseph Calvin Kouokam et al.   PLoS One

The Glycan Shield of HIV Is Predominantly Oligomannose Independently of Production System or Viral Clade

(2011) Camille Bonomelli et al.   PLoS One

Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C

(2011) Geoffrey Férir et al.   VIROLOGY

Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction

(2011) Xin Huang et al.   VIROLOGY

Intravaginal rings: controlled release systems for contraception and prevention of transmission of sexually transmitted infections

(2011) David R. Friend   Drug Delivery and Translational Research

Sustained release of proteins from a modified vaginal ring device

(2010) Ryan J. Morrow et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

(2010) Tinoush Moulaei et al.   STRUCTURE

Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin

(2010) Kabamba B. Alexandre et al.   VIROLOGY

Evidence that Ecotropic Murine Leukemia Virus Contamination in TZM-bl Cells Does Not Affect the Outcome of Neutralizing Antibody Assays with Human Immunodeficiency Virus Type 1

(2009) E. J. Platt et al.   JOURNAL OF VIROLOGY

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

(2009) B. R. O'Keefe et al.   JOURNAL OF VIROLOGY

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

(2009) B. R. O'Keefe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional studies of the potent anti-HIV chemokine variant P2-RANTES

(2009) Hongjun Jin et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Glycosylation Site-Specific Analysis of HIV Envelope Proteins (JR-FL and CON-S) Reveals Major Differences in Glycosylation Site Occupancy, Glycoform Profiles, and Antigenic Epitopesʼ Accessibility

(2008) Eden P. Go et al.   JOURNAL OF PROTEOME RESEARCH

Identification of Gammaretroviruses Constitutively Released from Cell Lines Used for Human Immunodeficiency Virus Research

(2008) Y. Takeuchi et al.   JOURNAL OF VIROLOGY

Molecular architecture of native HIV-1 gp120 trimers

(2008) Jun Liu et al.   NATURE