Lectins with Anti-HIV Activity: A Review

Structural analysis and binding properties of isoforms of tarin, the GNA-related lectin from Colocasia esculenta

(2015) Patrícia R. Pereira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus

(2014) Aura R. Garrison et al.   ANTIVIRAL RESEARCH

Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family

(2014) Geoffrey Férir et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Intracellular mannose binding lectin mediates subcellular trafficking of HIV-1 gp120 in neurons

(2014) C. Teodorof et al.   NEUROBIOLOGY OF DISEASE

Linker-Extended Native Cyanovirin-N Facilitates PEGylation and Potently Inhibits HIV-1 by Targeting the Glycan Ligand

(2014) Jia Chen et al.   PLoS One

Purification and Characterization of a Mucin Specific Mycelial Lectin from Aspergillus gorakhpurensis: Application for Mitogenic and Antimicrobial Activity

(2014) Ram Sarup Singh et al.   PLoS One

Antiviral lectins as potential HIV microbicides

(2014) Leonardus MI Koharudin et al.   Current Opinion in Virology

The antiviral lectin cyanovirin-N: probing multivalency and glycan recognition through experimental and computational approaches

(2013) Brian W. Woodrum et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

In silicoanalysis of molecular mechanisms of legume lectin-induced apoptosis in cancer cells

(2013) Z. Shi et al.   CELL PROLIFERATION

Differential Inhibitory Effects of Cyanovirin-N, Griffithsin, and Scytovirin on Entry Mediated by Envelopes of Gammaretroviruses and Deltaretroviruses

(2013) S. M. R. Jensen et al.   JOURNAL OF VIROLOGY

Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN

(2013) Kabamba B. Alexandre et al.   VIROLOGY

Combinations of Griffithsin with Other Carbohydrate-Binding Agents Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate-Binding Agent-Resistant HIV Type 1 Strains

(2012) Geoffrey Férir et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Algal Lectins as Potential HIV Microbicide Candidates

(2012) Dana Huskens et al.   Marine Drugs

The Role of Individual Carbohydrate-Binding Sites in the Function of the Potent Anti-HIV Lectin Griffithsin

(2012) Jie Xue et al.   MOLECULAR PHARMACEUTICS

The high mannose-type glycan binding lectin actinohivin: dimerization greatly improves anti-HIV activity

(2011) Atsushi Takahashi et al.   JOURNAL OF ANTIBIOTICS

Solution Structure of the Monovalent Lectin Microvirin in Complex with Manα(1–2)Man Provides a Basis for Anti-HIV Activity with Low Toxicity

(2011) Syed Shahzad-ul-Hussan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Mannose-binding Lectin with Preference for the Cluster of α1–2-Mannose from the Green AlgaBoodlea coactaIs a Potent Entry Inhibitor of HIV-1 and Influenza Viruses

(2011) Yuichiro Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin

(2011) X. Huang et al.   JOURNAL OF GENERAL VIROLOGY

Molecular modeling, docking and dynamics simulations of GNA-related lectins for potential prevention of influenza virus (H1N1)

(2011) Huai-long Xu et al.   JOURNAL OF MOLECULAR MODELING

Binding of the Mannose-Specific Lectin, Griffithsin, to HIV-1 gp120 Exposes the CD4-Binding Site

(2011) K. B. Alexandre et al.   JOURNAL OF VIROLOGY

Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate

(2011) Joseph Calvin Kouokam et al.   PLoS One

Structural Basis of the Anti-HIV Activity of the Cyanobacterial Oscillatoria Agardhii Agglutinin

(2011) Leonardus M.I. Koharudin et al.   STRUCTURE

Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C

(2011) Geoffrey Férir et al.   VIROLOGY

The antiviral protein cyanovirin-N: the current state of its production and applications

(2010) Sheng Xiong et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Manipulation of dendritic cell function by viruses

(2010) Anthony L Cunningham et al.   CURRENT OPINION IN MICROBIOLOGY

A Lectin Isolated from Bananas Is a Potent Inhibitor of HIV Replication

(2010) Michael D. Swanson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microvirin, a Novel α(1,2)-Mannose-specific Lectin Isolated fromMicrocystis aeruginosa, Has Anti-HIV-1 Activity Comparable with That of Cyanovirin-N but a Much Higher Safety Profile

(2010) Dana Huskens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure

(2010) Jingjin Ding et al.   JOURNAL OF STRUCTURAL BIOLOGY

Potential Anti-HIV Agents from Marine Resources: An Overview

(2010) Thanh-Sang Vo et al.   Marine Drugs

Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin

(2010) Kabamba B. Alexandre et al.   VIROLOGY

Molecular mechanisms ofPolygonatum cyrtonemalectin-induced apoptosis and autophagy in cancer cells

(2009) Bo Liu et al.   Autophagy

Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma L929 cells

(2009) Bo Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

In vitro anti-HIV activity of five selected South African medicinal plant extracts

(2009) M. Klos et al.   JOURNAL OF ETHNOPHARMACOLOGY

Mechanism by which the lectin actinohivin blocks HIV infection of target cells

(2009) H. Tanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

(2009) B. R. O'Keefe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS–p38–p53 pathway

(2008) Bo Liu et al.   CANCER LETTERS

C-type lectin Mermaid inhibits dendritic cell mediated HIV-1 transmission to CD4+ T cells

(2008) Alexey A. Nabatov et al.   VIROLOGY

PEGylation of cyanovirin–N, an entry inhibitor of HIV

(2007) H. Zappe et al.   ADVANCED DRUG DELIVERY REVIEWS