Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

(2016) Guillaume B.E. Stewart-Jones et al.   CELL

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV

(2016) Evangelia Vamvaka et al.   PLANT BIOTECHNOLOGY JOURNAL

Hepatitis C Virus Resistance to Carbohydrate-Binding Agents

(2016) Laure Izquierdo et al.   PLoS One

Griffithsin binds to the glycosylated proteins (E and prM) of Japanese encephalitis virus and inhibit its infection

(2016) Hassan Z.A. Ishag et al.   VIRUS RESEARCH

Binding Site Geometry and Subdomain Valency Control Effects of Neutralizing Lectins on HIV-1 Viral Particles

(2016) Sabrina Lusvarghi et al.   ACS Infectious Diseases

Glycopeptide Mimetics Recapitulate High-Mannose-Type Oligosaccharide Binding and Function

(2015) Sabrina Lusvarghi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus

(2015) Keith Levendosky et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Improving the large scale purification of the HIV microbicide, griffithsin

(2015) Joshua L Fuqua et al.   BMC BIOTECHNOLOGY

HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth

(2015) Priyamvada Acharya et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Sensitivity of transmitted and founder human immunodeficiency virus type 1 envelopes to carbohydrate-binding agents griffithsin, cyanovirin-N and Galanthus nivalis agglutinin

(2015) Bodan Hu et al.   JOURNAL OF GENERAL VIROLOGY

Lectins with Anti-HIV Activity: A Review

(2015) Ouafae Akkouh et al.   MOLECULES

Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus

(2015) Tinoush Moulaei et al.   Retrovirology

Viral membrane fusion

(2015) Stephen C. Harrison   VIROLOGY

Anti-Retroviral Lectins Have Modest Effects on Adherence of Trichomonas vaginalis to Epithelial Cells In Vitro and on Recovery of Tritrichomonas foetus in a Mouse Vaginal Model

(2015) Aparajita Chatterjee et al.   PLoS One

Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family

(2014) Geoffrey Férir et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A novel and fully scalableAgrobacteriumspray-based process for manufacturing cellulases and other cost-sensitive proteins in plants

(2014) Simone Hahn et al.   PLANT BIOTECHNOLOGY JOURNAL

Efficient Single Tobamoviral Vector-Based Bioproduction of Broadly Neutralizing Anti-HIV-1 Monoclonal Antibody VRC01 in Nicotiana benthamiana Plants and Utility of VRC01 in Combination Microbicides

(2013) Krystal Teasley Hamorsky et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Griffithsin Dimer Is Required for High-Potency Inhibition of HIV-1: Evidence for Manipulation of the Structure of gp120 as Part of the Griffithsin Dimer Mechanism

(2013) Jie Xue et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity of and Effect of Subcutaneous Treatment with the Broad-Spectrum Antiviral Lectin Griffithsin in Two Laboratory Rodent Models

(2013) Christopher Barton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Differential Inhibitory Effects of Cyanovirin-N, Griffithsin, and Scytovirin on Entry Mediated by Envelopes of Gammaretroviruses and Deltaretroviruses

(2013) S. M. R. Jensen et al.   JOURNAL OF VIROLOGY

Griffithsin Protects Mice from Genital Herpes by Preventing Cell-to-Cell Spread

(2013) B. Nixon et al.   JOURNAL OF VIROLOGY

Current progress in development of hepatitis C virus vaccines

(2013) T Jake Liang   NATURE MEDICINE

Antiviral Lectins from Red and Blue-Green Algae Show Potent In Vitro and In Vivo Activity against Hepatitis C Virus

(2013) Yutaka Takebe et al.   PLoS One

Role of the Carbohydrate-Binding Sites of Griffithsin in the Prevention of DC-SIGN-Mediated Capture and Transmission of HIV-1

(2013) Bart Hoorelbeke et al.   PLoS One

Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN

(2013) Kabamba B. Alexandre et al.   VIROLOGY

Combinations of Griffithsin with Other Carbohydrate-Binding Agents Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate-Binding Agent-Resistant HIV Type 1 Strains

(2012) Geoffrey Férir et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo

(2012) Hassan Z. A. Ishag et al.   ARCHIVES OF VIROLOGY

The Role of Individual Carbohydrate-Binding Sites in the Function of the Potent Anti-HIV Lectin Griffithsin

(2012) Jie Xue et al.   MOLECULAR PHARMACEUTICS

Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses

(2012) D. R. Burton et al.   SCIENCE

Occluding the Mannose Moieties on Human Immunodeficiency Virus Type 1 gp120 with Griffithsin Improves the Antibody Responses to Both Proteins in Mice

(2011) Kaustuv Banerjee et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Griffithsin Has Antiviral Activity against Hepatitis C Virus

(2011) Philip Meuleman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin

(2011) X. Huang et al.   JOURNAL OF GENERAL VIROLOGY

Binding of the Mannose-Specific Lectin, Griffithsin, to HIV-1 gp120 Exposes the CD4-Binding Site

(2011) K. B. Alexandre et al.   JOURNAL OF VIROLOGY

Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate

(2011) Joseph Calvin Kouokam et al.   PLoS One

Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C

(2011) Geoffrey Férir et al.   VIROLOGY

The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4+ cells

(2011) Kabamba B. Alexandre et al.   VIROLOGY

Potent Strategy To Inhibit HIV-1 by Binding both gp120 and gp41

(2010) Ioannis Kagiampakis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potential of carbohydrate-binding agents as therapeutics against enveloped viruses

(2010) K. O. François et al.   MEDICINAL RESEARCH REVIEWS

Grifonin-1: A Small HIV-1 Entry Inhibitor Derived from the Algal Lectin, Griffithsin

(2010) Ewa D. Micewicz et al.   PLoS One

Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

(2010) Tinoush Moulaei et al.   STRUCTURE

Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin

(2010) Kabamba B. Alexandre et al.   VIROLOGY

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

(2009) B. R. O'Keefe et al.   JOURNAL OF VIROLOGY

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

(2009) B. R. O'Keefe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA