Griffithsin Protects Mice from Genital Herpes by Preventing Cell-to-Cell Spread

A Perspective on Progress and Gaps in HIV Prevention Science

(2012) Patrick F. Kiser et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Changes in the Soluble Mucosal Immune Environment During Genital Herpes Outbreaks

(2012) Marla J. Keller et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Herpes Simplex Virus 2 (HSV-2) Prevents Dendritic Cell Maturation, Induces Apoptosis, and Triggers Release of Proinflammatory Cytokines: Potential Links to HSV-HIV Synergy

(2012) Martha Stefanidou et al.   JOURNAL OF VIROLOGY

Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women

(2012) Jared M. Baeten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preexposure Prophylaxis for HIV Infection among African Women

(2012) Lut Van Damme et al.   NEW ENGLAND JOURNAL OF MEDICINE

In VitroActivities of Candidate Microbicides against Cell-Associated HIV

(2011) Philippe Selhorst et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pre-Exposure Prophylaxis and Antiretroviral Resistance: HIV Prevention at a Cost?

(2011) C. B. Hurt et al.   CLINICAL INFECTIOUS DISEASES

Tenofovir-based pre-exposure prophylaxis for HIV prevention

(2011) Connie Celum et al.   CURRENT OPINION IN INFECTIOUS DISEASES

A Live-Attenuated HSV-2 ICP0− Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit Vaccine

(2011) William P. Halford et al.   PLoS One

Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate

(2011) Joseph Calvin Kouokam et al.   PLoS One

The Glycan Shield of HIV Is Predominantly Oligomannose Independently of Production System or Viral Clade

(2011) Camille Bonomelli et al.   PLoS One

Bridging the Gap between Preclinical and Clinical Microbicide Trials: Blind Evaluation of Candidate Gels in Murine Models of Efficacy and Safety

(2011) Theodore J. Segarra et al.   PLoS One

Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C

(2011) Geoffrey Férir et al.   VIROLOGY

PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial

(2010) Sheena McCormack et al.   LANCET

Postcoital Bioavailability and Antiviral Activity of 0.5% PRO 2000 Gel: Implications for Future Microbicide Clinical Trials

(2010) Marla J. Keller et al.   PLoS One

Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens

(2010) K. J. Doores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

(2010) Tinoush Moulaei et al.   STRUCTURE

Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin

(2010) Kabamba B. Alexandre et al.   VIROLOGY

A sugar binding protein cyanovirin-N blocks herpes simplex virus type-1 entry and cell fusion

(2009) Vaibhav Tiwari et al.   ANTIVIRAL RESEARCH

Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety

(2009) Sarah S Wilson et al.   ANTIVIRAL THERAPY

Disruption of Tight Junctions by Cellulose Sulfate Facilitates HIV Infection: Model of Microbicide Safety

(2009) Pedro M. M. Mesquita et al.   JOURNAL OF INFECTIOUS DISEASES

Evasion of the Mucosal Innate Immune System by Herpes Simplex Virus Type 2

(2009) T. Peng et al.   JOURNAL OF VIROLOGY

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

(2009) B. R. O'Keefe et al.   JOURNAL OF VIROLOGY

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

(2009) B. R. O'Keefe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Candidate Microbicide PPCM Blocks Human Immunodeficiency Virus Type 1 Infection in Cell and Tissue Cultures and Prevents Genital Herpes in a Murine Model

(2008) P. M. M. Mesquita et al.   JOURNAL OF VIROLOGY

Lack of Effectiveness of Cellulose Sulfate Gel for the Prevention of Vaginal HIV Transmission

(2008) Lut Van Damme et al.   NEW ENGLAND JOURNAL OF MEDICINE