Broadly Neutralizing Antibodies as Treatment: Effects on Virus and Immune System

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

(2016) Johannes F. Scheid et al.   NATURE

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques

(2016) Ann J Hessell et al.   NATURE MEDICINE

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1

(2016) T. Schoofs et al.   SCIENCE

Sustained virologic control in SIV+ macaques after antiretroviral and  4 7 antibody therapy

(2016) S. N. Byrareddy et al.   SCIENCE

Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection

(2016) Kshitij Wagh et al.   PLoS Pathogens

Passive transfer of neutralizing mAb KD-247 reduces plasma viral load in patients chronically infected with HIV-1

(2015) Shuzo Matsushita et al.   AIDS

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

(2015) Tongqing Zhou et al.   CELL

Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses

(2015) M. Anthony Moody et al.   Cell Host & Microbe

Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

(2015) Vashti Irani et al.   MOLECULAR IMMUNOLOGY

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

(2015) Marina Caskey et al.   NATURE

Antibody responses to envelope glycoproteins in HIV-1 infection

(2015) Dennis R Burton et al.   NATURE IMMUNOLOGY

Insights into the trimeric HIV-1 envelope glycoprotein structure

(2015) Andrew B. Ward et al.   TRENDS IN BIOCHEMICAL SCIENCES

Activation and lysis of human CD4 cells latently infected with HIV-1

(2015) Amarendra Pegu et al.   Nature Communications

Vectored antibody gene delivery for the prevention or treatment of HIV infection

(2015) Cailin E. Deal et al.   Current Opinion in HIV and AIDS

HIV broadly neutralizing antibody targets

(2015) Constantinos Kurt Wibmer et al.   Current Opinion in HIV and AIDS

History of passive antibody administration for prevention and treatment of infectious diseases

(2015) Barney S. Graham et al.   Current Opinion in HIV and AIDS

Prospects for engineering HIV-specific antibodies for enhanced effector function and half-life

(2015) Austin W. Boesch et al.   Current Opinion in HIV and AIDS

Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

(2014) Sung-Youl Ko et al.   NATURE

Development of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infection

(2014) Cynthia A. Derdeyn et al.   Current Opinion in HIV and AIDS

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

(2013) Tongqing Zhou et al.   IMMUNITY

HIV-1 neutralizing antibodies: understanding nature's pathways

(2013) John R. Mascola et al.   IMMUNOLOGICAL REVIEWS

Global Panel of HIV-1 Env Reference Strains for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies

(2013) A. deCamp et al.   JOURNAL OF VIROLOGY

Antibodies in HIV-1 Vaccine Development and Therapy

(2013) F. Klein et al.   SCIENCE

New paradigms for functional HIV-specific nonneutralizing antibodies

(2013) Don Forthal et al.   Current Opinion in HIV and AIDS

Viral Escape from Neutralizing Antibodies in Early Subtype A HIV-1 Infection Drives an Increase in Autologous Neutralization Breadth

(2013) Megan K. Murphy et al.   PLoS Pathogens

Broadly Neutralizing Antibodies Developed by an HIV-Positive Elite Neutralizer Exact a Replication Fitness Cost on the Contemporaneous Virus

(2012) D. N. Sather et al.   JOURNAL OF VIROLOGY

Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site

(2012) X. Wu et al.   JOURNAL OF VIROLOGY

Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape

(2012) Penny L Moore et al.   NATURE MEDICINE

Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120

(2012) Anthony P. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breadth of Human Immunodeficiency Virus-Specific Neutralizing Activity in Sera: Clustering Analysis and Association with Clinical Variables

(2009) N. A. Doria-Rose et al.   JOURNAL OF VIROLOGY

Breadth of Neutralizing Antibody Response to Human Immunodeficiency Virus Type 1 Is Affected by Factors Early in Infection but Does Not Influence Disease Progression

(2009) A. Piantadosi et al.   JOURNAL OF VIROLOGY

Escape from Autologous Neutralizing Antibodies in Acute/Early Subtype C HIV-1 Infection Requires Multiple Pathways

(2009) Rong Rong et al.   PLoS Pathogens