Roles, function and relevance of LAG3 in HIV infection

Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z

(2018) Salvatore Sciacchitano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Establishment of engineered cell-based assays mediating LAG3 and PD1 immune suppression enables potency measurement of blocking antibodies and assessment of signal transduction

(2018) Bhagyashree Bhagwat et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Immunotherapy of melanoma

(2018) Iwona Lugowska et al.   Wspolczesna Onkologia-Contemporary Oncology

Regulatory T cells in retroviral infections

(2018) Kim J. Hasenkrug et al.   PLoS Pathogens

Regulatory T Cells As Potential Targets for HIV Cure Research

(2018) Adam J. Kleinman et al.   Frontiers in Immunology

Exposure to Plasmodium vivax is associated with the increased expression of exhaustion markers on γδ T lymphocytes

(2018) Dimpu Gogoi et al.   PARASITE IMMUNOLOGY

iNKT Cells Orchestrate a Switch from Inflammation to Resolution of Sterile Liver Injury

(2017) Pei Xiong Liew et al.   IMMUNITY

Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy

(2017) Cynthia L. Gay et al.   JOURNAL OF INFECTIOUS DISEASES

Increasing LAG-3 expression suppresses T-cell function in chronic hepatitis B

(2017) Bo Ye et al.   MEDICINE

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression

(2017) Christopher R. Shaler et al.   PLOS BIOLOGY

PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells

(2017) Carmen Stecher et al.   Frontiers in Immunology

PD-1 blockade augments anti-neuroblastoma immune response induced by anti-GD2 antibody ch14.18/CHO

(2017) Nikolai Siebert et al.   OncoImmunology

CD4+ T-cell gene expression of healthy donors, HIV-1 and elite controllers: Immunological chaos

(2016) G. Nunnari et al.   CYTOKINE

CD8 + Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy

(2016) Emily K. Cartwright et al.   IMMUNITY

LAG-3 Confers a Competitive Disadvantage upon Antiviral CD8+T Cell Responses

(2016) Kevin D. Cook et al.   JOURNAL OF IMMUNOLOGY

Multiple Inhibitory Pathways Contribute to Lung CD8+T Cell Impairment and Protect against Immunopathology during Acute Viral Respiratory Infection

(2016) John J. Erickson et al.   JOURNAL OF IMMUNOLOGY

Functional role of mucosal-associated invariant T cells in HIV infection

(2016) Alireza Saeidi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3

(2016) Atsushi Kadowaki et al.   Nature Communications

CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART

(2016) Rémi Fromentin et al.   PLoS Pathogens

Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection

(2016) Matthias Hoffmann et al.   PLoS Pathogens

Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer

(2016) Ruea-Yea Huang et al.   OncoImmunology

Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice

(2016) Susan P. Foy et al.   PLoS One

Effect of ipilimumab on the HIV reservoir in an HIV-infected individual with metastatic melanoma

(2015) Fiona Wightman et al.   AIDS

Short Communication: Low Expression of Activation and Inhibitory Molecules on NK Cells and CD4+ T Cells Is Associated with Viral Control

(2015) Natalia A. Taborda et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

LAG3 Expression in Active Mycobacterium tuberculosis Infections

(2015) Bonnie L. Phillips et al.   AMERICAN JOURNAL OF PATHOLOGY

Lymphocyte activation gene 3 negatively regulates the function of intrahepatic hepatitis C virus-specific CD8+T cells

(2015) Na Chen et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The Upregulation of LAG-3 on T Cells Defines a Subpopulation with Functional Exhaustion and Correlates with Disease Progression in HIV-Infected Subjects

(2015) Xiaoling Tian et al.   JOURNAL OF IMMUNOLOGY

Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment

(2015) Jennifer A Juno et al.   Retrovirology

Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options

(2015) Vijayakumar Velu et al.   Retrovirology

Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells

(2015) T. Kouo et al.   Cancer Immunology Research

LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses

(2014) F. Xu et al.   CANCER RESEARCH

Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6

(2014) Sheng-Fan Wang et al.   GLYCOBIOLOGY

Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

(2014) Alison Crawford et al.   IMMUNITY

Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II

(2014) Bitao Liang et al.   JOURNAL OF IMMUNOLOGY

Trafficking of LAG-3 to the Surface on Activated T Cells via Its Cytoplasmic Domain and Protein Kinase C Signaling

(2014) Joonbeom Bae et al.   JOURNAL OF IMMUNOLOGY

Triggering Through Toll-like Receptor 2 Limits Chronically Stimulated T-helper Type 1 Cells From Undergoing Exhaustion

(2014) Sathi Babu Chodisetti et al.   JOURNAL OF INFECTIOUS DISEASES

Alternative Activation of Human Plasmacytoid DCs In Vitro and in Melanoma Lesions: Involvement of LAG-3

(2014) Chiara Camisaschi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Role of Lymphocyte Activation Gene-3 (Lag-3) in Conventional and Regulatory T Cell Function in Allogeneic Transplantation

(2014) Emanuela I. Sega et al.   PLoS One

Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo

(2014) Nicholas M. Durham et al.   PLoS One

Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy

(2014) Bronwen R. Burton et al.   Nature Communications

Liver fibrosis in HIV

(2014) Jürgen K. Rockstroh et al.   Current Opinion in HIV and AIDS

T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

(2014) Marcus Buggert et al.   PLoS Pathogens

Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations

(2013) Haoyu Sun et al.   CYTOKINE

Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+T cells

(2013) Yukiko Iwasaki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Liver Environment and HCV Replication Affect Human T-Cell Phenotype and Expression of Inhibitory Receptors

(2013) Daniela C. Kroy et al.   GASTROENTEROLOGY

PD-1 Blockade in Chronically HIV-1-Infected Humanized Mice Suppresses Viral Loads

(2013) Edward Seung et al.   PLoS One

The split personality of regulatory T cells in HIV infection

(2012) M. F. Chevalier et al.   BLOOD

Invariant NKT Cells: Regulation and Function during Viral Infection

(2012) Jennifer A. Juno et al.   PLoS Pathogens

Responsiveness of HIV-specific CD4 T cells to PD-1 blockade

(2011) F. Porichis et al.   BLOOD

Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection

(2011) T. Yamamoto et al.   BLOOD

Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque

(2011) Margalida Rotger et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection

(2011) Charlly Kao et al.   NATURE IMMUNOLOGY

Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4

(2010) Seng-Ryong Woo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation

(2010) Tadashi Yokosuka et al.   IMMUNITY

Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance

(2010) Melissa Swiecki et al.   IMMUNOLOGICAL REVIEWS

LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites

(2010) C. Camisaschi et al.   JOURNAL OF IMMUNOLOGY

Purging the HIV-1 reservoir through the disruption of the PD-1 pathway

(2010) S DaFonseca et al.   Journal of the International AIDS Society

Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells

(2009) J. F. Grosso et al.   JOURNAL OF IMMUNOLOGY

LAG-3 Regulates Plasmacytoid Dendritic Cell Homeostasis

(2009) C. J. Workman et al.   JOURNAL OF IMMUNOLOGY

CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2

(2009) T. Okamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Selective expansion of a subset of exhausted CD8 T cells by  PD-L1 blockade

(2008) S. D. Blackburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA