QiDiTangShen Granules Activate Renal Nutrient-Sensing Associated Autophagy in db/db Mice

Diabetic nephropathy: recent advances in pathophysiology and challenges in dietary management

(2019) Mahaboob Khan Sulaiman   Diabetology & Metabolic Syndrome

Role of sirtuin-1 in diabetic nephropathy

(2019) Wanning Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Phosphoregulation on mitochondria: Integration of cell and organelle responses

(2019) Maribel Lucero et al.   CNS Neuroscience & Therapeutics

Discovery and anticancer evaluation of a formononetin derivative against gastric cancer SGC7901 cells

(2019) Jian-Ning Yao et al.   INVESTIGATIONAL NEW DRUGS

Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes

(2019) Shinsuke Sakai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Research Progress on the Antitumor Effects of Rhein: Literature Review

(2018) Chao Wu et al.   Anti-Cancer Agents in Medicinal Chemistry

QiDiTangShen Granules Reduced Diabetic Kidney Injury by Regulating the Phosphorylation Balance of the Tyrosine and Serine Residues of Insulin Receptor Substrate 1

(2018) Xue Gao et al.   Evidence-based Complementary and Alternative Medicine

Kaempferol alleviates palmitic acid-induced lipid stores, endoplasmic reticulum stress and pancreatic β-cell dysfunction through AMPK/mTOR-mediated lipophagy

(2018) Ritu Varshney et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

UPLC-HRMS-Based Plasma Metabolomic Profiling of Novel Biomarkers by Treatment with KDZI in Cerebral Ischemia Reperfusion Rats

(2018) Chunguo Wang et al.   MOLECULES

Calycosin directly improves perivascular adipose tissue dysfunction by upregulating the adiponectin/AMPK/eNOS pathway in obese mice

(2018) Fang Han et al.   Food & Function

Antidiabetic Activity of a Flavonoid-Rich Extract From Sophora davidii (Franch.) Skeels in KK-Ay Mice via Activation of AMP-Activated Protein Kinase

(2018) Yun Huang et al.   Frontiers in Pharmacology

Formononetin inhibits lipopolysaccharide-induced release of high mobility group box 1 by upregulating SIRT1 in a PPARδ-dependent manner

(2018) Jung Seok Hwang et al.   PeerJ

Activation of autophagy contributes to the renoprotective effect of postconditioning on acute kidney injury and renal fibrosis

(2018) Yaolin Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aloe-emodin ameliorates renal fibrosis via inhibiting PI3K/Akt/mTOR signaling pathway in vivo and in vitro

(2018) Fang Dou et al.   REJUVENATION RESEARCH

Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway

(2018) Haitao Sun et al.   MEDICAL SCIENCE MONITOR

Astragalus Polysaccharide Improves Insulin Sensitivity via AMPK Activation in 3T3-L1 Adipocytes

(2018) Ruixin Zhang et al.   MOLECULES

Autophagy and disease

(2017) Andrew Thorburn   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of nutraceutical SIRT1 modulators in AMPK and mTOR pathway: Evidence of a synergistic effect

(2017) Luca Giovannini et al.   NUTRITION

Luteolin reduces migration of human glioblastoma cell lines via inhibition of the p-IGF-1R/PI3K/AKT/mTOR signaling pathway

(2017) Qiang Wang et al.   Oncology Letters

The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy

(2017) Sonia Sifuentes-Franco et al.   Journal of Diabetes Research

Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling

(2017) Yue Tu et al.   Scientific Reports

Emodin alleviates hepatic steatosis by inhibiting sterol regulatory element binding protein 1 activity by way of the calcium/calmodulin-dependent kinase kinase-AMP-activated protein kinase-mechanistic target of rapamycin-p70 ribosomal S6 kinase signaling

(2016) Shaojie Wang et al.   HEPATOLOGY RESEARCH

Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact

(2016) Tian Yang et al.   Molecular Medicine Reports

mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management

(2015) Silvia Cetrullo et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1

(2015) Zhen Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis

(2015) Yan Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Autophagy in diabetic nephropathy

(2014) Yan Ding et al.   JOURNAL OF ENDOCRINOLOGY

SIRT1 Positively Regulates Autophagy and Mitochondria Function in Embryonic Stem Cells Under Oxidative Stress

(2014) Xuan Ou et al.   STEM CELLS

Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?

(2013) G C Higgins et al.   BRITISH JOURNAL OF PHARMACOLOGY

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Nutrient Sensing, Autophagy, and Diabetic Nephropathy

(2011) S. Kume et al.   DIABETES

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

Molecular mechanisms of diabetic vascular complications

(2010) Munehiro Kitada et al.   Journal of Diabetes Investigation

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA