Emodin alleviates hepatic steatosis by inhibiting sterol regulatory element binding protein 1 activity by way of the calcium/calmodulin-dependent kinase kinase-AMP-activated protein kinase-mechanistic target of rapamycin-p70 ribosomal S6 kinase signaling

Emodin ameliorates hepatic steatosis through endoplasmic reticulum-stress sterol regulatory element-binding protein 1c pathway in liquid fructose-feeding rats

(2015) Xiaojie Li et al.   HEPATOLOGY RESEARCH

Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals

(2013) Howard C. Masuoka et al.   Annals of the New York Academy of Sciences

A Central Role for mTOR in Lipid Homeostasis

(2013) Dudley W. Lamming et al.   Cell Metabolism

The Role of Lifestyle Change in the Prevention and Treatment of NAFLD

(2013) Elena Centis et al.   CURRENT PHARMACEUTICAL DESIGN

Emerging drugs for non-alcoholic steatohepatitis

(2013) Wataru Tomeno et al.   EXPERT OPINION ON EMERGING DRUGS

Emodin Regulates Glucose Utilization by Activating AMP-activated Protein Kinase

(2013) Parkyong Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emodin, a Naturally Occurring Anthraquinone Derivative, Ameliorates Dyslipidemia by Activating AMP-Activated Protein Kinase in High-Fat-Diet-Fed Rats

(2012) Thing-Fong Tzeng et al.   Evidence-based Complementary and Alternative Medicine

Promotion of adiponectin multimerization by emodin: A novel AMPK activator with PPARγ-agonist activity

(2012) Zhifen Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Emodin Protects against High-Fat Diet-Induced Obesity via Regulation of AMP-Activated Protein Kinase Pathways in White Adipose Tissue

(2012) Thing-Fong Tzeng et al.   PLANTA MEDICA

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

(2012) J. L. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Emodin, a natural product, selectively inhibits 11β-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice

(2010) Ying Feng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Fatty liver incidence and predictive variables

(2010) Akira Tsuneto et al.   HYPERTENSION RESEARCH

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

A novel non-alcoholic steatohepatitis animal model featured with insulin resistance, hepatic inflammation and fibrosis

(2010) Jingmin Zhao et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid -Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease

(2010) James P. Hardwick et al.   PPAR Research

Anti-diabetic effects of emodin involved in the activation of PPARγ on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice

(2009) Jianfeng Xue et al.   FITOTERAPIA

Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones

(2009) Seong Hwan Hwahng et al.   HEPATOLOGY

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Emodin inhibits TNF-α-induced human aortic smooth-muscle cell proliferation via caspase- and mitochondrial-dependent apoptosis

(2008) Sook-Kyoung Heo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

SREBPs: the crossroads of physiological and pathological lipid homeostasis

(2008) Rajendra Raghow et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis

(2008) Fabio Marra et al.   TRENDS IN MOLECULAR MEDICINE