Cullin Ring Ubiquitin Ligases (CRLs) in Cancer: Responses to Ionizing Radiation (IR) Treatment

H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

(2019) Kyosuke Nakamura et al.   NATURE CELL BIOLOGY

The anti-resection activity of the X protein encoded by Hepatitis Virus B

(2019) Laifeng Ren et al.   HEPATOLOGY

The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons

(2018) Itay Koren et al.   CELL

Abscopal effect of radiotherapy combined with immune checkpoint inhibitors

(2018) Yang Liu et al.   Journal of Hematology & Oncology

Dimerization quality control ensures neuronal development and survival

(2018) Elijah L. Mena et al.   SCIENCE

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

(2018) Nina M. S. Gustafsson et al.   Nature Communications

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression

(2018) Ioanna Mavrommati et al.   Cell Reports

Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs

(2018) Sainan An et al.   EBioMedicine

The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers

(2018) Antonio Marzio et al.   MOLECULAR CELL

Track to the future: historical perspective on the importance of radiation track structure and DNA as a radiobiological target

(2017) Mark A. Hill   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair

(2017) Nozomi Tomimatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Neddylation Inhibitor Pevonedistat (MLN4924) Suppresses and Radiosensitizes Head and Neck Squamous Carcinoma Cells and Tumors

(2017) Vanessa Vanderdys et al.   MOLECULAR CANCER THERAPEUTICS

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

(2017) Jinfang Zhang et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

(2017) Calla M Olson et al.   Nature Chemical Biology

Small-Molecule PROTACS: New Approaches to Protein Degradation

(2016) Momar Toure et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair

(2016) Noriko Ishida et al.   MOLECULAR AND CELLULAR BIOLOGY

FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4

(2016) Qiang Zhang et al.   MOLECULAR CELL

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

(2016) Petra Schwertman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells

(2016) Seung Ho Baek et al.   PHYTOMEDICINE

Radiosensitization of Human Colorectal Cancer Cells by MLN4924

(2016) Juefeng Wan et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence

(2016) Yoshikazu Johmura et al.   Nature Communications

CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection

(2016) Ming Zeng et al.   Nature Communications

Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection

(2016) Lorenza P. Ferretti et al.   Nature Communications

Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

(2016) Youngtae Jeong et al.   Cancer Discovery

Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications

(2016) Hsin-Yi Chen et al.   Frontiers in Oncology

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

(2015) Jing Lu et al.   CHEMISTRY & BIOLOGY

Inhibition of APOBEC3G activity impedes double-stranded DNA repair

(2015) Ponnandy Prabhu et al.   FEBS Journal

Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B

(2015) Jeffrey Hannah et al.   GENE

WSB1 promotes tumor metastasis by inducing pVHL degradation

(2015) Jung Jin Kim et al.   GENES & DEVELOPMENT

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response

(2015) Andrew E.H. Elia et al.   MOLECULAR CELL

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice

(2015) Ismail Hassan Ismail et al.   NATURE CELL BIOLOGY

Catalytic in vivo protein knockdown by small-molecule PROTACs

(2015) Daniel P Bondeson et al.   Nature Chemical Biology

Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control

(2015) Ditte Kjærsgaard Klein et al.   Nature Communications

CUL4A contributes to the biology of basal-like breast tumors through modulation of cell growth and antitumor immune response

(2015) Laura P. Saucedo-Cuevas et al.   Oncotarget

NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer

(2015) Tatsuhiro Shibata et al.   NEOPLASIA

Radiation promotes malignant progression of glioma cells through HIF-1alpha stabilization

(2014) Young-Heon Kim et al.   CANCER LETTERS

p16INK4a Impairs Homologous Recombination–Mediated DNA Repair in Human Papillomavirus–Positive Head and Neck Tumors

(2014) Rüveyda Dok et al.   CANCER RESEARCH

Speckle-type POZ protein, SPOP, is involved in the DNA damage response

(2014) D. Zhang et al.   CARCINOGENESIS

CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression

(2013) Yunshan Wang et al.   CANCER RESEARCH

Enhanced Radiation Sensitivity in HPV-Positive Head and Neck Cancer

(2013) R. J. Kimple et al.   CANCER RESEARCH

An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation

(2013) Lisa Postow et al.   CELL CYCLE

The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications

(2013) Pascal Genschik et al.   EMBO JOURNAL

Cullin 4B is a novel prognostic marker that correlates with colon cancer progression and pathogenesis

(2013) Tao Jiang et al.   MEDICAL ONCOLOGY

Regulation of the CRL4Cdt2 Ubiquitin Ligase and Cell-Cycle Exit by the SCFFbxo11 Ubiquitin Ligase

(2013) Mario Rossi et al.   MOLECULAR CELL

CRL1-FBXO11 Promotes Cdt2 Ubiquitylation and Degradation and Regulates Pr-Set7/Set8-Mediated Cellular Migration

(2013) Tarek Abbas et al.   MOLECULAR CELL

CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis

(2012) Huili Hu et al.   CANCER CELL

Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair

(2012) Vincenzo D'Angiolella et al.   CELL

Somatic mutations of the KEAP1 gene in common solid cancers

(2012) Nam Jin Yoo et al.   HISTOPATHOLOGY

The F-box Protein FBXO44 Mediates BRCA1 Ubiquitination and Degradation

(2012) Yunzhe Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

(2012) J. R. Chapman et al.   JOURNAL OF CELL SCIENCE

MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination

(2012) F. Zhang et al.   JOURNAL OF CELL SCIENCE

Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling

(2012) Hendrik J. Kuiken et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs

(2012) Rebecca Mathew et al.   NATURE

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair

(2012) Lin Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HDM-2 inhibition suppresses expression of ribonucleotide reductase subunit M2, and synergistically enhances gemcitabine-induced cytotoxicity in mantle cell lymphoma

(2011) R. J. Jones et al.   BLOOD

A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression

(2011) Wei-Chien Yuan et al.   CANCER CELL

Radiosensitization of Human Pancreatic Cancer Cells by MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor

(2011) D. Wei et al.   CANCER RESEARCH

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

(2011) P. A. Konstantinopoulos et al.   CANCER RESEARCH

The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation

(2011) Qian Cheng et al.   CELL CYCLE

Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!

(2011) Andrea Scrima et al.   FEBS LETTERS

Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions

(2011) Barbara Iovine et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of JAK2 Signaling by TG101209 Enhances Radiotherapy in Lung Cancer Models

(2011) Yunguang Sun et al.   Journal of Thoracic Oncology

SCFFBXO22 Regulates Histone H3 Lysine 9 and 36 Methylation Levels by Targeting Histone Demethylase KDM4A for Ubiquitin-Mediated Proteasomal Degradation

(2011) M.-K. M. Tan et al.   MOLECULAR AND CELLULAR BIOLOGY

The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings

(2011) Thomas Helleday   Molecular Oncology

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

The cullin protein family

(2011) Antonio Sarikas et al.   GENOME BIOLOGY

Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase

(2010) Hiroyuki Inuzuka et al.   CANCER CELL

Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features

(2010) L. M. Solis et al.   CLINICAL CANCER RESEARCH

Break-induced ATR and Ddb1-Cul4Cdt2 ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast

(2010) J. Moss et al.   GENES & DEVELOPMENT

Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4Cdt2-mediated proteolysis

(2010) Masato Michishita et al.   GENES TO CELLS

Ribonucleotide reductase M2 subunit is a novel diagnostic marker and a potential therapeutic target in bladder cancer

(2010) Teppei Morikawa et al.   HISTOPATHOLOGY

Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro

(2010) Teppei Morikawa et al.   HUMAN PATHOLOGY

Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

(2010) P. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation

(2010) Tarek Abbas et al.   MOLECULAR CELL

Delayed repair of radiation induced clustered DNA damage: Friend or foe?

(2010) Laura J. Eccles et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction

(2010) Y Honaker et al.   ONCOGENE

Stress-Activated Mitogen-Activated Protein Kinases c-Jun NH2-Terminal Kinase and p38 Target Cdc25B for Degradation

(2009) S. Uchida et al.   CANCER RESEARCH

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

(2009) Feng Zhang et al.   CURRENT BIOLOGY

Hypoxia and Radiation Therapy: Past History, Ongoing Research, and Future Promise

(2009) Sara Rockwell et al.   CURRENT MOLECULAR MEDICINE

UV-DDB: A molecular machine linking DNA repair with ubiquitination

(2009) Kaoru Sugasawa   DNA REPAIR

Ionizing Radiation Induces ATM-independent Degradation of p21Cip1in Transformed Cells

(2009) Scott A. Stuart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Nuclear Localization Signal in the N Terminus of CUL4B and Its Essential Role in Cyclin E Degradation and Cell Cycle Progression

(2009) Yongxin Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cul4A is an oncogene in malignant pleural mesothelioma

(2009) Ming-Szu Hung et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Extracellular Signal-regulated Kinase–Mitogen-activated Protein Kinase Pathway Phosphorylates and Targets Cdc25A for SCFβ-TrCP-dependent Degradation for Cell Cycle Arrest

(2009) Michitaka Isoda et al.   MOLECULAR BIOLOGY OF THE CELL

SOCS1 Links Cytokine Signaling to p53 and Senescence

(2009) Viviane Calabrese et al.   MOLECULAR CELL

The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress

(2009) You-Wei Zhang et al.   MOLECULAR CELL

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

(2009) Courtney G. Havens et al.   MOLECULAR CELL

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

(2009) Manas K. Santra et al.   NATURE

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint

(2009) Marina Melixetian et al.   NATURE CELL BIOLOGY

BRCA1 and its toolbox for the maintenance of genome integrity

(2009) Michael S.Y. Huen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MEPE/OF45 protects cells from DNA damage induced killing via stabilizing CHK1

(2009) Shuang Liu et al.   NUCLEIC ACIDS RESEARCH

JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation

(2009) L. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP

(2009) Yifeng Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

(2009) S. M. H. Sy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

(2008) Ashley R. Schneekloth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

p53 induces distinct epigenetic states at its direct target promoters

(2008) Lukas Vrba et al.   BMC GENOMICS

GSK-3β Targets Cdc25A for Ubiquitin-Mediated Proteolysis, and GSK-3β Inactivation Correlates with Cdc25A Overproduction in Human Cancers

(2008) Tiebang Kang et al.   CANCER CELL

Broad Overexpression of Ribonucleotide Reductase Genes in Mice Specifically Induces Lung Neoplasms

(2008) X. Xu et al.   CANCER RESEARCH

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

(2008) T. Ohta et al.   CANCER RESEARCH

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage

(2008) John C. Sitko et al.   CELLULAR SIGNALLING

Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer

(2008) Tatsuhiro Shibata et al.   GASTROENTEROLOGY

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

(2008) T. Abbas et al.   GENES & DEVELOPMENT

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing

(2008) Y. Kim et al.   GENES & DEVELOPMENT

Regulation of TIP60 by ATF2 Modulates ATM Activation

(2008) Anindita Bhoumik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ku80 removal from DNA through double strand break–induced ubiquitylation

(2008) Lisa Postow et al.   JOURNAL OF CELL BIOLOGY

Genotoxic Stress-Induced Cyclin D1 Phosphorylation and Proteolysis Are Required for Genomic Stability

(2008) L. L. Pontano et al.   MOLECULAR AND CELLULAR BIOLOGY

Skp2 Regulates G2/M Progression in a p53-dependent Manner

(2008) Rong Hu et al.   MOLECULAR BIOLOGY OF THE CELL

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA