SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence

Regulation of GATA-binding Protein 2 Levels via Ubiquitin-dependent Degradation by Fbw7

(2015) Tomomi Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine-specific modifications of p53: a matter of life and death?

(2015) Diana Marouco et al.   Oncotarget

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Limiting the power of p53 through the ubiquitin proteasome pathway

(2014) Vinod Pant et al.   GENES & DEVELOPMENT

Transient Activation of p53 in G2 Phase Is Sufficient to Induce Senescence

(2014) Lenno Krenning et al.   MOLECULAR CELL

Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction

(2014) Yoshikazu Johmura et al.   MOLECULAR CELL

The role of ubiquitin modification in the regulation of p53

(2013) Andreas K. Hock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity

(2013) V. Pant et al.   GENES & DEVELOPMENT

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

MDM2’s social network

(2013) R Fåhraeus et al.   ONCOGENE

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53

(2012) Gaofeng Cui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

JMJD2A Promotes Cellular Transformation by Blocking Cellular Senescence through Transcriptional Repression of the Tumor Suppressor CHD5

(2012) Frédérick A. Mallette et al.   Cell Reports

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

p53 regulation by ubiquitin

(2011) Christopher L. Brooks et al.   FEBS LETTERS

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

SCFFBXO22 Regulates Histone H3 Lysine 9 and 36 Methylation Levels by Targeting Histone Demethylase KDM4A for Ubiquitin-Mediated Proteasomal Degradation

(2011) M.-K. M. Tan et al.   MOLECULAR AND CELLULAR BIOLOGY

The impact of acetylation and deacetylation on the p53 pathway

(2011) Christopher L. Brooks et al.   Protein & Cell

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

The Peroxisome Proliferator-Activated Receptor  /Retinoid X Receptor   Heterodimer Targets the Histone Modification Enzyme PR-Set7/Setd8 Gene and Regulates Adipogenesis through a Positive Feedback Loop

(2009) K.-i. Wakabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

p53 induces distinct epigenetic states at its direct target promoters

(2008) Lukas Vrba et al.   BMC GENOMICS

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL