Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4Cdt2-mediated proteolysis

CRL4Cdt2 E3 Ubiquitin Ligase Monoubiquitinates PCNA to Promote Translesion DNA Synthesis

(2010) Kenta Terai et al.   MOLECULAR CELL

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

(2009) Courtney G. Havens et al.   MOLECULAR CELL

Intrinsic Negative Cell Cycle Regulation Provided by PIP Box- and Cul4Cdt2-Mediated Destruction of E2f1 during S Phase

(2008) Shusaku T. Shibutani et al.   DEVELOPMENTAL CELL

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

(2008) T. Abbas et al.   GENES & DEVELOPMENT

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing

(2008) Y. Kim et al.   GENES & DEVELOPMENT

CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2Pathway during S Phase and after UV Irradiation

(2008) Hideo Nishitani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulated Proteolysis of DNA Polymerase η during the DNA-Damage Response in C. elegans

(2008) Seung-Hwan Kim et al.   MOLECULAR CELL