Journal
CELLS
Volume 7, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/cells7070082
Keywords
TRPM2; brain; aging; neurodegeneration; neurodegenerative disease
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Funding
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR), PRIN 2015 [20152HKF3Z]
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Transient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian TRP channels having been recognized. Among them, TRP-melastatin 2 (TRPM2) is particularly involved in the response to oxidative stress and inflammation, while its activity depends on the presence of intracellular calcium (Ca2+). TRPM2 is involved in several physiological and pathological processes in the brain through the modulation of multiple signaling pathways. The aim of the present review is to provide a brief summary of the current insights of TRPM2 role in health and disease to focalize our attention on future potential neuroprotective strategies.
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