Article
Biochemistry & Molecular Biology
Simon Sander, Jelena Pick, Ellen Gattkowski, Ralf Fliegert, Henning Tidow
Summary: Transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable channel involved in various physiological processes. ADP-ribose and 2'-deoxy-ADPR can activate TRPM2 by binding to its MHR1/2 domain. A previously unrecognized zinc-binding domain was discovered, which plays a critical role in TRPM2 activation.
Article
Immunology
Niels C. Lory, Mikolaj Nawrocki, Martina Corazza, Joanna Schmid, Valea Schumacher, Tanja Bedke, Stephan Menzel, Friedrich Koch-Nolte, Andreas H. Guse, Samuel Huber, Hans-Willi Mittruecker
Summary: This study investigates the function of TRPM2 in T-cell activation and differentiation using TRPM2-deficient mice. The results suggest that TRPM2 does not play a major role in T-cell activation and differentiation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Xiafe Yu, Yuan Xie, Xiaokang Zhang, Cheng Ma, Likun Liu, Wenxuan Zhen, Lingyi Xu, Jianmin Zhang, Yan Liang, Lixia Zhao, Xiuxia Gao, Peilin Yu, Jianhong Luo, Lin-Hua Jiang, Yan Nie, Fan Yang, Jiangtao Guo, Wei Yang
Summary: The study revealed the structure and gating mechanism of human TRPM2 channel by combining cryo-EM structure and functional studies, identifying the ion selectivity filter and providing insights into the gating mechanism of the channel.
Article
Neurosciences
Shusheng Wu, Yuye Yin, Longfei Du
Summary: This study demonstrates the critical role of FUS aggregates in astrocyte activation in ischemic stroke and uncovers a possible molecular mechanism underlying this process. By promoting autophagic cell injury or death, FUS aggregates worsen neurofunctional damages and stroke outcomes.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Cell Biology
Julian M. Carosi, Leanne K. Hein, Mark van den Hurk, Robert Adams, Bridget Milky, Sanjna Singh, Cedric Bardy, Donna Denton, Sharad Kumar, Timothy J. Sargeant
Summary: The autophagy-lysosome axis is crucial for the clearance of MAPT aggregates, with dysfunction of the central retromer component VPS35 leading to impaired autophagic resolution and accumulation of cytoplasmic MAPT aggregates. Maintaining the integrity of the retromer complex regulates the autophagy-lysosome axis to suppress MAPT aggregation and propagation.
Article
Medicine, Research & Experimental
Binfeng Yu, Lini Jin, Xi Yao, Yi Zhang, Gensheng Zhang, Fangqin Wang, Xinwan Su, Qiuyuan Fang, Liang Xiao, Yi Yang, Lin-Hua Jiang, Jianghua Chen, Wei Yang, Weiqiang Lin, Fei Han
Summary: This study found that the TRPM2 channel plays a protective role in cisplatin-induced acute kidney injury. Deficiency of TRPM2 exacerbates renal dysfunction, tubular injury, and cell apoptosis, while treatment alleviates these damages. In addition, TRPM2 deficiency hinders cisplatin-induced autophagy. These findings provide new insights into the pathogenesis of kidney injury.
Article
Multidisciplinary Sciences
Jennifer Cable, Eilika Weber-Ban, Tim Clausen, Kylie J. Walters, Michal Sharon, Daniel J. Finley, Yangnan Gu, John Hanna, Yue Feng, Sascha Martens, Anne Simonsen, Malene Hansen, Hong Zhang, Jonathan M. Goodwin, Alessio Reggio, Chunmei Chang, Liang Ge, Brenda A. Schulman, Raymond J. Deshaies, Ivan Dikic, J. Wade Harper, Ingrid E. Wertz, Nicolas H. Thoma, Mikolaj Slabicki, Judith Frydman, Ursula Jakob, Della C. David, Eric J. Bennett, Carolyn R. Bertozzi, Richa Sardana, Vinay V. Eapen, Serena Carra
Summary: Targeted protein degradation is essential for cellular function and development. This process involves tightly regulated protein degradation pathways to eliminate misfolded and aggregated proteins, adjust protein levels during cellular differentiation, and selectively eliminate target proteins. Understanding these pathways can provide insights into disease pathology and the development of novel therapeutics.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Editorial Material
Cell Biology
Antonio Monaco, Alessandro Fraldi
Summary: Mucopolysaccharidoses (MPS) are inherited metabolic diseases with strong neurological involvement. Impairment of autophagy pathway is a key factor driving neurodegeneration in MPS, particularly downstream of the GAG storage.
Review
Biochemistry & Molecular Biology
Raquel Gomez-Sintes, Esperanza Arias
Summary: Chaperone-mediated autophagy (CMA) is a proteolytic process that selectively degrades intracellular proteins inside lysosomes, participating in the modulation of specific regulatory proteins. Impairment of CMA function may contribute to the pathogenesis of neurodegenerative diseases and cancer, making it a potential therapeutic target for these conditions. Recent evidence has revealed the important and complex role of CMA in cancer biology, with implications for tumor development and the response to cancer therapeutics.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Editorial Material
Cell Biology
Zhihai Zhang, Daniel J. Klionsky
Summary: Protein aggregates are closely related to the pathogenesis of various human diseases. A recent study identified CCT2 as a specific aggrephagy receptor in mammals, which plays a role in the autophagic clearance of protein aggregates. This finding suggests that CCT2 could be an important target for treating protein aggregation-related diseases.
Article
Cell Biology
Rui Lin, Xunxia Bao, Hui Wang, Sibo Zhu, Zhongyan Liu, Quanning Chen, Kaixing Ai, Baomin Shi
Summary: The mechanism of TRPM2 in pancreatic cancer involves the activation of PKC/MAPK pathways, leading to enhanced proliferation, migration, and invasion abilities of PA cells. TRPM2 is negatively correlated with overall survival and progression-free survival time in PA patients, while its expression increases with tumor stage. Inhibitors of PKC/MEK significantly inhibit PA cell growth, suggesting a potential therapeutic target for pancreatic cancer.
CELL DEATH & DISEASE
(2021)
Review
Pharmacology & Pharmacy
Ruixue Shi, Yu Fu, Dongyi Zhao, Tomasz Boczek, Wuyang Wang, Feng Guo
Summary: TRPM channels, important members of the TRP family, play crucial roles in cell physiology and cell death. Studies have shown their involvement in various cell death modalities, suggesting their potential as therapeutic targets in cell death-related diseases.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Liyan Chen, Liying Zhu, Xingyu Lu, Xiaoyu Ming, Baoshan Yang
Summary: This study found that HBV infection promotes the expression of TRPM2, which interacts with p47 phox to induce autophagy and facilitate HBV replication. Silencing TRPM2 can inhibit HBV replication and autophagy.
JOURNAL OF VIRAL HEPATITIS
(2022)
Review
Physiology
Maria Maliougina, Yassine El Hiani
Summary: TRPM2 is a versatile and essential signaling molecule involved in Ca2+ homeostasis and oxidative stress signaling, with implications in various diseases. It is a promising therapeutic target, but whether to activate or inhibit TRPM2 function depends on the context and specific disease. A better understanding of TRPM2 activation and regulation could lead to innovative therapeutics for a broad range of diseases.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cell Biology
Niharika Amireddy, Vandana Dulam, Shweta Kaul, Rajeswari Pakkiri, Shasi V. Kalivendi
Summary: Upregulation and aggregation of a-synuclein is a key factor in Parkinson's disease, and mitochondrial dysfunction is believed to be a contributing factor. The drug nitazoxanide has been found to enhance mitochondrial function and autophagy. This study demonstrates that nitazoxanide activates cellular autophagy and clears a-synuclein aggregates through mitochondrial uncoupling, AMPK activation, and JNK activation.
CELLULAR SIGNALLING
(2023)
Article
Critical Care Medicine
Yoonje Lee, Sanjaya Ricky, Tae Ho Lim, Hongjung Kim, Eui Jung Lee, Yeongtak Song, Sunmi Lee, Yongwoo Jang
Summary: In this study, we assessed the effectiveness of plasma jet treatment in altering the expression of genes involved in wound healing. We found that plasma treatment significantly decreased the expression of proinflammatory cytokines.
JOURNAL OF BURN CARE & RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yong Soo Park, Bong -Woo Park, Hayoung Choi, Seung Hee Lee, Myungshin Kim, Hun-Jun Park, In-Beom Kim
Summary: This study found that compared to umbilical cord-derived mesenchymal stem cells (UC-MSCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs), chorion-derived mesenchymal stem cells (C-MSCs) showed better therapeutic efficacy in a rat myocardial infarction (MI) model, promoting cardiomyocyte differentiation and capillary formation.
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Hong-Lim Kim, Tae-Ryong Riew, Jieun Park, Youngchun Lee, In-Beom Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Yeop Choi, In-Beom Kim
Summary: This study defined all the motor nerve systems passing through the medial canthal area and found that in addition to the angular nerve, the upper medial palpebral branch also serves as a motor supplier in this region, providing motor function to the upper eyelid and the periorbital muscles.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Nanoscience & Nanotechnology
Yongwoo Jang, Ji Hwan Moon, Chanho Lee, Sung Min Lee, Heesoo Kim, Gyu Hyeon Song, Geoffrey M. Spinks, Gordon G. Wallace, Seon Jeong Kim
Summary: This article introduces a surface electromyogram (sEMG) device that utilizes nanotechnology to recognize the strength, direction, and degree of muscle movement. By combining sEMG with nanoelectrodes, complementary information can be provided for monitoring human motion.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Immunology
Hye Won Kwak, Wooseok Shin, Kyunghwa Baik, Minsun Kim, YongWook Park, So-Hee Hong, Hyo-Jung Park, Hyeong-Jun Park, Yoo-Jin Bang, Jae-Yong Kim, Yu-Sun Lee, In-Beom Kim, Hong-Lim Kim, Hun Kim, Jae-Hwan Nam
Summary: This study investigated the effects of a 10-valent HPV VLP vaccine formulated with ssRNA adjuvant and alum on enhancing immune response and maintaining memory response. The results showed that the vaccine formulated with ssRNA adjuvant and alum increased antigen-specific immune response and induced memory response. The combination of ssRNA adjuvant and alum balanced Th1/Th2 responses and could potentially enhance prophylactic vaccine efficacy.
MICROBIOLOGY AND IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Eunyoung Kim, Yongwoo Jang, Hyunsoo Kim, Dong Yeop Lee, Jung Gi Choi, Seon Jeong Kim
Summary: DNA artificial muscle can undergo reversible movement under calcium stimulation, similar to the contraction mechanism of natural muscle. This artificial muscle has high work performance and has great potential for biomedical applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Surgery
Sang-Hyun Kim, In-Beom Kim, Yeop Choi
Summary: The tension of the sensory nerve and mobility of the gliding layers in the brow have an impact on the postoperative brow level in endoscopic brow lift surgery. The study suggests that considering the supraorbital nerve tension and gliding-layer mobility is crucial to achieve the desired brow level in endoscopic brow lifts.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Neurosciences
Hyungsup Kim, Hyesu Kim, Luan Thien Nguyen, Taewoong Ha, Sujin Lim, Kyungmin Kim, Soon Ho Kim, Kyungreem Han, Seung Jae Hyeon, Hoon Ryu, Yong Soo Park, Sang Hyun Kim, In-Beom Kim, Gyu-Sang Hong, Seung Eun Lee, Yunsook Choi, Lawrence B. Cohen, Uhtaek Oh
Summary: Animals rely on olfaction to determine the smells of foods, prey, or predators. The Anoctamin 9 channel in olfactory sensory neurons plays a crucial role in amplifying olfactory signals, impacting mammalian olfactory transduction.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Materials Science, Biomaterials
Dong Yeop Lee, Yongwoo Jang, Eunyoung Kim, Tao Li, Seon Jeong Kim
Summary: The tissue-engineered vascular graft (TEVG) is a promising alternative for small-diameter blood vessel replacement, and a bioresorbable polyglycolic acid (PGA) fiber-knitted tubular scaffold shows potential as a flexible and durable support for vascular cells. The PGA tubular knit serves as a porous three-dimensional matrix for cell attachment and growth, and it can withstand mechanical damage and maintain suturability.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Multidisciplinary
Tao Li, Yongwoo Jang, Jung Gi Choi, Dong Yeop Lee, Jae Sang Hyeon, Seon Jeong Kim
Summary: In this study, a high water content hydrogel fiber with increased stretchability was developed through biomimetic design. The fiber self-coiled under aqueous conditions, resulting in high water content and stretchability. This has potential implications for various medical applications.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Multidisciplinary Sciences
Jun Woo Park, Eun Jung Lee, Eunyoung Moon, Hong-Lim Kim, In-Beom Kim, Didier Hodzic, Namsuk Kim, Hee-Seok Kweon, Jin Woo Kim
Summary: Many homeodomain transcription factors, such as OTX2, are secreted and move to neighboring cells. The unconventional nuclear export and secretion of OTX2 through nuclear budding vesicles and the involvement of Tor1a and the LINC complex are essential for maintaining cellular functions and preventing aggregation.
NATURE COMMUNICATIONS
(2023)
Article
Anatomy & Morphology
Hong-Fu Liu, Yan-Lian Xiong, In-Beom Kim, Hyung-Sun Won, Chang-Zhu Jin
Summary: This study validated and compared the anatomical variations of the superior intercostal veins, analyzing their origin, course, anastomoses, and destination. The study involved dissection and measurement of superior intercostal veins in 50 Korean and 16 Chinese adult cadavers. The findings identified and classified different morphologic types of the superior intercostal vein and highlighted its clinical significance.
Article
Biochemistry & Molecular Biology
Jung Woo Han, Hun Soo Chang, Jin Young Yang, Han Sol Choi, Hyo Song Park, Hyoung Oh Jun, Ji Hye Choi, Sun-Sook Paik, Kyung Hwun Chung, Hee Jeong Shin, Seungyeon Nam, Ji-Hye Son, Si Hyung Lee, Eun Jung Lee, Kyoung Yul Seo, Jungmook Lyu, Jin Woo Kim, In-Beom Kim, Tae Kwann Park
Summary: Increasing evidence shows that exosomes and their microRNAs play important roles in retinal cell degeneration and visual function. In this study, retinal organoids (ROs) were generated from induced pluripotent stem cells and exosomes were extracted from them. Injecting these exosomes into rat eyes reduced photoreceptor apoptosis, prevented outer nuclear layer thinning, and preserved visual function. RNA sequencing and miRNA profiling revealed that exosomal miRNAs are mainly involved in the MAPK signaling pathway. The results suggest that targeting this pathway with Exo-ROs may delay retinal degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Hee Young Lim, Sang-Hyun Kim, Jung-woo Choi, So-Youn Chang, Ga Hye Kim, In-Beom Kim, Yong-Seok Nam, Jong In Lee
Summary: In this study, a novel needle insertion point for electromyography (EMG) of the serratus anterior (SA) was identified, which avoids injury to adjacent muscles and the long thoracic nerve (LTN). The accuracy of the new method was verified in cadavers. Compared to the conventional midaxillary method, the novel method improved the accuracy of needle EMG of the SA.
