Journal
CELL CALCIUM
Volume 76, Issue -, Pages 132-134Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2018.11.001
Keywords
TRP channel; Ion channel structure; ADPR; Calcium
Categories
Funding
- Deutsche Forschungsgemeinschaft [SFB1328]
- EU [DLV-813284]
- Joachim-Herz-Foundation, Infectophysics consortium
- [NIHP41-GM103311 [14]]
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Transient receptor potential cation channel, subtype melastatin 2 (TRPM2), is important for several physiological functions, such as immune response or temperature regulation. Recently, the structure of full-length TRPM2 from zebrafish was published (Huang et al., 2018) proposing a new activation mechanism - is it really a paradigm shift or just reflects evolution of the channel?.
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